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Annotation rule MF_01965 |
General rule information
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Accession |
MF_01965 |
Dates |
14-FEB-2012 (Created) 19-NOV-2019 (Last updated, Version 10) |
case <OC:Bacteria> or <OC:Archaea>
end case
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=ADP-dependent (S)-NAD(P)H-hydrate dehydratase;
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EC 4.2.1.136;
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AltName:
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Full=ADP-dependent NAD(P)HX dehydratase;
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Function |
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. |
Catalytic activity |
RHEA:32223: (6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate
EC 4.2.1.136
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RHEA:32235: (6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate
EC 4.2.1.136
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Cofactor |
Mg(2+) |
Subunit |
Homotetramer. |
Similarity |
Belongs to the NnrD/CARKD family. |
GO:0052855; Molecular function: ADP-dependent NAD(P)H-hydrate dehydratase activity.
GO:0046496; Biological process: nicotinamide nucleotide metabolic process.
From: NNRD_BACSU (P94368) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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186
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190
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ADP
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K-x(4)
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NP_BIND
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206
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215
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ADP
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x(7)-G-x-G
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REGION
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149
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155
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NAD(P)HX
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x(3)-E-x(3)
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BINDING
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104
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104
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NAD(P)HX; via amide nitrogen
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BINDING
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216
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216
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NAD(P)HX
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D
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Additional information
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Size range |
257-304 amino acids |
Related rules |
None |
Fusion |
Nter: MF_01966 (nrrE); Cter: None |