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Annotation rule MF_01965
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General rule information [?]

Accession MF_01965
Dates 14-FEB-2012 (Created)
19-NOV-2019 (Last updated, Version 10)
Name NADHX_dehydratase
Scope
Bacteria
Archaea
Templates P94368 (NNRD_BACSU); P31806 (NNR_ECOLI); Q9X024 (NNR_THEMA): [Recover all]
case <OC:Bacteria> or <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NNRD
Protein name
RecName: Full=ADP-dependent (S)-NAD(P)H-hydrate dehydratase;
EC 4.2.1.136;
AltName: Full=ADP-dependent NAD(P)HX dehydratase;
Gene name
nnrD

Comments [?]

Function Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalytic activity RHEA:32223: (6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate
EC 4.2.1.136
RHEA:32235: (6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate
EC 4.2.1.136
Cofactor Mg(2+)
Subunit Homotetramer.
Similarity Belongs to the NnrD/CARKD family.

Keywords [?]

ATP-binding
Lyase
NAD
NADP
Nucleotide-binding

Gene Ontology [?]

GO:0052855; Molecular function: ADP-dependent NAD(P)H-hydrate dehydratase activity.
GO:0046496; Biological process: nicotinamide nucleotide metabolic process.

Cross-references [?]

PROSITE PS01049; YJEF_C_1; 1;
PS01050; YJEF_C_2; 1;
PS51383; YJEF_C_3; 1; trigger=PRU00715;
Pfam PF01256; Carb_kinase; 1;
TIGRFAMs TIGR00196; YjeF_C; 1;

Features [?]

From: NNRD_BACSU (P94368)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     186     190       ADP     K-x(4)  
NP_BIND     206     215       ADP     x(7)-G-x-G  
REGION     149     155       NAD(P)HX     x(3)-E-x(3)  
BINDING     104     104       NAD(P)HX; via amide nitrogen        
BINDING     216     216       NAD(P)HX     D  

Additional information [?]

Size range 257-304 amino acids
Related rules None
Fusion Nter: MF_01966 (nrrE); Cter: None


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