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Annotation rule MF_01967
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General rule information [?]

Accession MF_01967
Dates 2-APR-2012 (Created)
19-NOV-2019 (Last updated, Version 9)
Name Sirtuin_ClassII
Template Q9Y6E7 (SIR4_HUMAN)
case <OC:Bacteria>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=NAD-dependent protein deacetylase;
AltName: Full=Regulatory protein SIR2 homolog;
Gene name

Comments [?]

Function NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Catalytic activity RHEA:43636: H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the sirtuin family. Class II subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0034979; Molecular function: NAD-dependent protein deacetylase activity.
GO:0070403; Molecular function: NAD+ binding.
GO:0006476; Biological process: protein deacetylation.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

PROSITE PS50305; SIRTUIN; 1; trigger=PRU00236;
Pfam PF02146; SIR2; 1;

Features [?]

From: SIR4_HUMAN (Q9Y6E7)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     62     82       NAD     G-A-G-x-S-T-x-x-G-[IV]-P-D-Y-R-x(7)  
NP_BIND     143     146       NAD     Q-N-V-D  
NP_BIND     260     262       NAD     G-[ST]-S  
NP_BIND     286     288       NAD     N-x-G  
ACT_SITE     161     161       Proton acceptor     H  
METAL     169     169       Zinc     C   1
METAL     172     172       Zinc     C   1
METAL     220     220       Zinc     C   1
METAL     223     223       Zinc     C   1
BINDING     304     304       NAD; via amide nitrogen        

Additional information [?]

Size range 273-373 amino acids
Related rules MF_01121 (NPD); MF_01968 (NPD)
Fusion None