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HAMAP rule MF_01967

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General rule information [?]

Accession MF_01967
Dates 2-APR-2012 (Created)
19-NOV-2022 (Last updated, Version 11)
Name Sirtuin_ClassII
Template Q9Y6E7 (SIR4_HUMAN)
case <OC:Bacteria>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=NAD-dependent protein deacetylase;
AltName: Full=Regulatory protein SIR2 homolog;
Gene name

Comments [?]

Function NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Catalytic activity RHEA:43636: H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the sirtuin family. Class II subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0034979; Molecular function: NAD-dependent protein deacetylase activity.
GO:0070403; Molecular function: NAD+ binding.
GO:0006476; Biological process: protein deacetylation.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

PROSITE PS50305; SIRTUIN; 1; trigger=PRU00236;
Pfam PF02146; SIR2; 1;

Features [?]

From: SIR4_HUMAN (Q9Y6E7)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     62     82       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     G-A-G-x-S-T-x-x-G-[IV]-P-D-Y-R-x(7)  
BINDING     143     146       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     Q-N-V-D  
BINDING     260     262       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     G-[ST]-S  
BINDING     286     288       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     N-x-G  
ACT_SITE     161     161       Proton acceptor     H  
BINDING     169     169       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     172     172       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     220     220       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     223     223       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     304     304       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540        

Additional information [?]

Size range 273-373 amino acids
Related rules MF_01121 (NPD); MF_01968 (NPD)
Fusion None