HAMAP rule MF_01967

General rule information [?]

Accession	MF_01967
Dates	2-APR-2012 (Created) 19-NOV-2022 (Last updated, Version 11)

Name	Sirtuin_ClassII

Scope

Bacteria

Template

Q9Y6E7 (SIR4_HUMAN)

case <OC:Bacteria>

Triggered by

HAMAP; MF_01967 (Get profile general information and statistics)

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NPD

Protein name

RecName:		Full=NAD-dependent protein deacetylase;
		EC 2.3.1.286;
AltName:		Full=Regulatory protein SIR2 homolog;

Gene name

cobB

Comments [?]

Function	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Catalytic activity	RHEA:43636: H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide EC 2.3.1.286

case <FTGroup:1>

Cofactor

Zn(2+)
Note: Binds 1 zinc ion per subunit.

end case

Subcellular location	Cytoplasm.
Similarity	Belongs to the sirtuin family. Class II subfamily.

Keywords [?]

Cytoplasm
NAD

case <FTGroup:1>

Metal-binding
Zinc

end case

Transferase

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0034979; Molecular function: NAD-dependent protein deacetylase activity.
GO:0070403; Molecular function: NAD+ binding.
GO:0006476; Biological process: protein deacetylation.

case <FTGroup:1>

GO:0008270; Molecular function: zinc ion binding.

end case

Cross-references [?]

PROSITE	PS50305; SIRTUIN; 1; trigger=PRU00236;
Pfam	PF02146; SIR2; 1;

Features [?]

From: SIR4_HUMAN (Q9Y6E7)

Key From To Description Tag Condition FTGroup

BINDING 62 82 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 G-A-G-x-S-T-x-x-G-[IV]-P-D-Y-R-x(7)

BINDING 143 146 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 Q-N-V-D

BINDING 260 262 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 G-[ST]-S

BINDING 286 288 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 N-x-G

ACT_SITE 161 161 Proton acceptor H

BINDING 169 169 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 172 172 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 220 220 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 223 223 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 304 304 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540

Additional information [?]

Size range	273-373 amino acids
Related rules	MF_01121 (NPD); MF_01968 (NPD)
Fusion	None

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