![]() |
|
Annotation rule MF_01967 |
Accession | MF_01967 |
Dates | 2-APR-2012 (Created) 19-NOV-2019 (Last updated, Version 9) |
Name | Sirtuin_ClassII |
Scope | Bacteria |
Template | Q9Y6E7 (SIR4_HUMAN) |
Triggered by |
Identifier |
|
Protein name |
|
Gene name |
|
Function | NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. |
Catalytic activity | RHEA:43636: H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
EC 2.3.1.286 |
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the sirtuin family. Class II subfamily. |
From: SIR4_HUMAN (Q9Y6E7) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 62 | 82 | NAD | G-A-G-x-S-T-x-x-G-[IV]-P-D-Y-R-x(7) | ||||||||
NP_BIND | 143 | 146 | NAD | Q-N-V-D | ||||||||
NP_BIND | 260 | 262 | NAD | G-[ST]-S | ||||||||
NP_BIND | 286 | 288 | NAD | N-x-G | ||||||||
ACT_SITE | 161 | 161 | Proton acceptor | H | ||||||||
METAL | 169 | 169 | Zinc | C | 1 | |||||||
METAL | 172 | 172 | Zinc | C | 1 | |||||||
METAL | 220 | 220 | Zinc | C | 1 | |||||||
METAL | 223 | 223 | Zinc | C | 1 | |||||||
BINDING | 304 | 304 | NAD; via amide nitrogen |