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HAMAP rule MF_01969

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General rule information [?]

Accession MF_01969
Dates 12-FEB-2009 (Created)
1-JUN-2023 (Last updated, Version 11)
Name KynB
Scope(s) Bacteria
Template(s) Q81CK1 (KYNB_BACCR); Q9I234 (KYNB_PSEAE); P0C8P4 (KYNB_CUPMC); Q81PP9 (KYNB_BACAN); B4E9I9 (KYNB_BURCJ); [ Recover all ]
Triggered by HAMAP; MF_01969 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KYNB
Protein name RecName: Full=Kynurenine formamidase;
                 Short=KFase;
                 Short=KFA;
                 EC=3.5.1.9;
AltName: Full=Arylformamidase;
AltName: Full=N-formylkynurenine formamidase;
                 Short=FKF;
Gene name Name=kynB;

Comments [?]

FUNCTIONCatalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
CATALYTIC ACTIVITY Reaction=H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine; Xref=Rhea:RHEA:13009, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:57959, ChEBI:CHEBI:58629; EC=3.5.1.9;
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 zinc ions per subunit.;
PATHWAYAmino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
SUBUNITHomodimer.
SIMILARITYBelongs to the Cyclase 1 superfamily. KynB family.

Keywords [?]


Gene Ontology [?]

GO:0004061; Molecular function:arylformamidase activity
GO:0008270; Molecular function:zinc ion binding
GO:0006569; Biological process:tryptophan catabolic process

Cross-references [?]

Pfam PF04199; Cyclase; 1;
NCBIfam TIGR03035; Trp_arylform; 1;

Features [?]

From: KYNB_BACAN (Q81PP9)
Key From To Description Tag Condition FTGroup
ACT_SITE 60 60 /note="Proton donor/acceptor" H
BINDING 50 50 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"
H
BINDING 54 54 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"
H
BINDING 56 56 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"
D
BINDING 56 56 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"
D
BINDING 161 161 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"
H
BINDING 173 173 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"
E
BINDING 173 173 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"
E
BINDING 20 20 /ligand="substrate" [WF]

Additional information [?]

Size range 209-223 amino acids
Related rules None
Fusion Nter: None Cter: None



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