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Annotation rule MF_01969
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General rule information [?]

Accession MF_01969
Dates 12-FEB-2009 (Created)
19-NOV-2019 (Last updated, Version 8)
Name KynB
Scope
Bacteria
Templates Q81CK1 (KYNB_BACCR); Q9I234 (KYNB_PSEAE); P0C8P4 (KYNB_CUPMC); Q81PP9 (KYNB_BACAN); B4E9I9 (KYNB_BURCJ): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KYNB
Protein name
RecName: Full=Kynurenine formamidase;
Short=KFase;
Short=KFA;
EC 3.5.1.9;
AltName: Full=Arylformamidase;
AltName: Full=N-formylkynurenine formamidase;
Short=FKF;
Gene name
kynB

Comments [?]

Function Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
Catalytic activity RHEA:13009: H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine
EC 3.5.1.9
Cofactor Zn(2+)
Note: Binds 2 zinc ions per subunit.
Pathway Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Subunit Homodimer.
Similarity Belongs to the Cyclase 1 superfamily. KynB family.

Keywords [?]

Hydrolase
Metal-binding
Tryptophan catabolism
Zinc

Gene Ontology [?]

GO:0004061; Molecular function: arylformamidase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0006569; Biological process: tryptophan catabolic process.

Cross-references [?]

Pfam PF04199; Cyclase; 1;
TIGRFAMs TIGR03035; Trp_arylform; 1;

Features [?]

From: KYNB_BACAN (Q81PP9)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     60     60       Proton donor/acceptor     H  
METAL     50     50       Zinc 1; via pros nitrogen     H  
METAL     54     54       Zinc 1; via tele nitrogen     H  
METAL     56     56       Zinc 1     D  
METAL     56     56       Zinc 2     D  
METAL     161     161       Zinc 2; via tele nitrogen     H  
METAL     173     173       Zinc 1     E  
METAL     173     173       Zinc 2     E  
BINDING     20     20       Substrate     [WF]  

Additional information [?]

Size range 209-223 amino acids
Related rules None
Fusion None


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