HAMAP rule MF_01969
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01969 |
| Accession | MF_01969 |
| Dates | 12-FEB-2009 (Created)
14-JAN-2025 (Last updated, Version 14) |
| Name | KynB |
| Scope(s) |
Bacteria |
| Template(s) | Q81CK1 (KYNB_BACCR); Q9I234 (KYNB_PSEAE); P0C8P4 (KYNB_CUPMC); Q81PP9 (KYNB_BACAN); B4E9I9 (KYNB_BURCJ); [ Recover all ] |
| Triggered by |
HAMAP; MF_01969 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KYNB |
| Protein name | RecName: Full=Kynurenine formamidase; Short=KFase; Short=KFA; EC=3.5.1.9; AltName: Full=Arylformamidase; AltName: Full=N-formylkynurenine formamidase; Short=FKF; |
| Gene name | Name=kynB; |
Comments
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| FUNCTION | Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. |
| CATALYTIC ACTIVITY | Reaction=N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+); Xref=Rhea:RHEA:13009, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:57959, ChEBI:CHEBI:58629; EC=3.5.1.9; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 zinc ions per subunit.; |
| PATHWAY | Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the Cyclase 1 superfamily. KynB family. |
Keywords
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Gene Ontology
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| GO:0004061; Molecular function:arylformamidase activity |
| GO:0008270; Molecular function:zinc ion binding |
| GO:0019441; Biological process:L-tryptophan catabolic process to kynurenine |
Cross-references
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Features
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| From: KYNB_BACAN (Q81PP9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 60 | 60 | /note="Proton donor/acceptor" | H | ||||||||
| BINDING | 50 | 50 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
| BINDING | 54 | 54 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
| BINDING | 56 | 56 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
D | ||||||||
| BINDING | 56 | 56 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
D | ||||||||
| BINDING | 161 | 161 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
H | ||||||||
| BINDING | 173 | 173 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
E | ||||||||
| BINDING | 173 | 173 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
E | ||||||||
| BINDING | 20 | 20 | /ligand="substrate" | [WF] | ||||||||
Additional information
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| Size range | 209-223 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |