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HAMAP rule MF_01971

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General rule information [?]

Accession MF_01971
Dates 12-FEB-2009 (Created)
19-NOV-2019 (Last updated, Version 10)
Name Kynurenine_monooxygenase
Scope(s) Bacteria
Template(s) Q84HF5 (KMO_PSEFL); Q11PP7 (KMO_CYTH3); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_01971 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KMO
Protein name RecName: Full=Kynurenine 3-monooxygenase;
                 EC=1.14.13.9;
AltName: Full=Kynurenine 3-hydroxylase;
Gene name Name=kmo;

Comments [?]

FUNCTIONCatalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
CATALYTIC ACTIVITY Reaction=H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+); Xref=Rhea:RHEA:20545, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:57959, ChEBI:CHEBI:58125, ChEBI:CHEBI:58349; EC=1.14.13.9;
COFACTOR Name=FAD; Xref=ChEBI:CHEBI:57692;
PATHWAYCofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
SIMILARITYBelongs to the aromatic-ring hydroxylase family. KMO subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004502; Molecular function:kynurenine 3-monooxygenase activity
GO:0050660; Molecular function:flavin adenine dinucleotide binding
GO:0006569; Biological process:tryptophan catabolic process
GO:0019805; Biological process:quinolinate biosynthetic process
GO:0034354; Biological process:'de novo' NAD biosynthetic process from tryptophan
GO:0043420; Biological process:anthranilate metabolic process

Cross-references [?]

Pfam PF01266; DAO; 1;
PRINTS PR00420; RNGMNOXGNASE; 1;

Features [?]


Additional information [?]

Size range 427-600 amino acids
Related rules None
Fusion Nter: None Cter: None



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