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Annotation rule MF_01971
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General rule information [?]

Accession MF_01971
Dates 12-FEB-2009 (Created)
19-NOV-2019 (Last updated, Version 10)
Name Kynurenine_monooxygenase
Scope
Bacteria
Templates Q84HF5 (KMO_PSEFL); Q11PP7 (KMO_CYTH3): [Recover all]
case <OC:Bacteria>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KMO
Protein name
RecName: Full=Kynurenine 3-monooxygenase;
EC 1.14.13.9;
AltName: Full=Kynurenine 3-hydroxylase;
Gene name
kmo

Comments [?]

Function Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
Catalytic activity RHEA:20545: H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)
EC 1.14.13.9
Cofactor FAD
Pathway Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Similarity Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004502; Molecular function: kynurenine 3-monooxygenase activity.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.

Cross-references [?]

Pfam PF01266; DAO; 1;
PRINTS PR00420; RNGMNOXGNASE; 1;

Additional information [?]

Size range 427-600 amino acids
Related rules None
Fusion None