HAMAP rule MF_01971
General rule information
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| Accession | MF_01971 |
| Dates | 12-FEB-2009 (Created)
3-SEP-2024 (Last updated, Version 11) |
| Name | Kynurenine_monooxygenase |
| Scope(s) |
Bacteria |
| Template(s) | Q84HF5 (KMO_PSEFL); Q11PP7 (KMO_CYTH3); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_01971 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KMO |
| Protein name | RecName: Full=Kynurenine 3-monooxygenase; EC=1.14.13.9; AltName: Full=Kynurenine 3-hydroxylase; |
| Gene name | Name=kmo; |
Comments
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| FUNCTION | Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. |
| CATALYTIC ACTIVITY | Reaction=L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O; Xref=Rhea:RHEA:20545, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:57959, ChEBI:CHEBI:58125, ChEBI:CHEBI:58349; EC=1.14.13.9; |
| COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
| PATHWAY | Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. |
| SIMILARITY | Belongs to the aromatic-ring hydroxylase family. KMO subfamily. |
Keywords
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Gene Ontology
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| GO:0004502; Molecular function:kynurenine 3-monooxygenase activity |
| GO:0050660; Molecular function:flavin adenine dinucleotide binding |
| GO:0006569; Biological process:tryptophan catabolic process |
| GO:0019805; Biological process:quinolinate biosynthetic process |
| GO:0034354; Biological process:'de novo' NAD biosynthetic process from tryptophan |
| GO:0043420; Biological process:anthranilate metabolic process |
Cross-references
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Features
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Additional information
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| Size range | 427-600 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |