HAMAP rule MF_01971
General rule information
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| Accession | MF_01971 |
| Dates | 12-FEB-2009 (Created) 19-NOV-2019 (Last updated, Version 10) |
| Name | Kynurenine_monooxygenase |
| Scope | Bacteria |
| Templates | Q84HF5 (KMO_PSEFL); Q11PP7 (KMO_CYTH3): [Recover all] |
case <OC:Bacteria>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. |
| Catalytic activity | RHEA:20545: H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)
EC 1.14.13.9 |
| Cofactor | FAD |
| Pathway | Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. |
| Similarity | Belongs to the aromatic-ring hydroxylase family. KMO subfamily. |
Keywords
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Gene Ontology
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GO:0004502; Molecular function: kynurenine 3-monooxygenase activity.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.
Cross-references
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Additional information
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| Size range | 427-600 amino acids |
| Related rules | None |
| Fusion | None |