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Annotation rule MF_02005
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General rule information [?]

Accession MF_02005
Dates 7-FEB-2006 (Created)
20-NOV-2019 (Last updated, Version 14)
Name Val_tRNA_synth_type2
Scope
Bacteria; Actinobacteria
Bacteria; Rickettsiales
Archaea
Templates P07118 (SYV_ECOLI); P96142 (SYV_THETH); P11931 (SYV_GEOSE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SYV
Protein name
RecName: Full=Valine--tRNA ligase;
EC 6.1.1.9;
AltName: Full=Valyl-tRNA synthetase;
Short=ValRS;
Gene name
valS

Comments [?]

Function Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
Catalytic activity RHEA:10704: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)
EC 6.1.1.9
case <OC:Bacteria>
Subunit Monomer.
end case
Subcellular location Cytoplasm.
Domain ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.
Similarity Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.

Keywords [?]

Cytoplasm
Aminoacyl-tRNA synthetase
ATP-binding
Ligase
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

GO:0004832; Molecular function: valine-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006438; Biological process: valyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00178; AA_TRNA_LIGASE_I; 1;
Pfam PF00133; tRNA-synt_1; 1;
PF08264; Anticodon_1; 1;
PRINTS PR00986; TRNASYNTHVAL; 1;
TIGRFAMs TIGR00422; ValS; 1;

Features [?]

From: SYV_RICPR (Q9ZCN6)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     46     56       'HIGH' region     P-[TYF]-x-[STA]-G-x-x-H-[ILMVP]-G-[HN]  
MOTIF     536     540       'KMSKS' region     [KRA]-M-S-K-S  
BINDING     539     539       ATP     K  

Additional information [?]

Size range 751-914 amino acids
Related rules MF_02004 (SYV)
Fusion None


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