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Annotation rule MF_02007
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General rule information [?]

Accession MF_02007
Dates 3-MAY-2006 (Created)
20-NOV-2019 (Last updated, Version 15)
Name Tyr_tRNA_synth_type2
Scope
Bacteria
Templates P0AGJ9 (SYY_ECOLI); P00952 (SYY_GEOSE); P41256 (SYY_ACIFR); Q57834 (SYY_METJA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SYY
Protein name
RecName: Full=Tyrosine--tRNA ligase;
EC 6.1.1.1;
AltName: Full=Tyrosyl-tRNA synthetase;
Short=TyrRS;
Gene name
tyrS

Comments [?]

Function Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Catalytic activity RHEA:10220: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)
EC 6.1.1.1
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004831; Molecular function: tyrosine-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006437; Biological process: tyrosyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00178; AA_TRNA_LIGASE_I; 1;
PS50889; S4; 1; trigger=PRU00182;
Pfam PF01479; S4; 1;
PF00579; tRNA-synt_1b; 1;
PRINTS PR01040; TRNASYNTHTYR; 1;
TIGRFAMs TIGR00234; TyrS; 1;

Features [?]

From: SYY_ACIFR (P41256)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     47     56       'HIGH' region     P-[TS]-[ARGS]-[PASTRK]-[DEN]-[LIV]-[HT]-[LIV]-G-[HA]  
MOTIF     231     235       'KMSKS' region     K-M-S-K-[ST]  
BINDING     234     234       ATP     K  

Additional information [?]

Size range 392-432 amino acids
Related rules MF_02006 (SYY); MF_02008 (SYY)
Fusion None
Comments Some species have a second copy of TyrRS in another subfamily (MF_02006).