HAMAP rule MF_02007
General rule information
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Accession | MF_02007 |
Dates | 3-MAY-2006 (Created) 19-NOV-2022 (Last updated, Version 17) |
Name | Tyr_tRNA_synth_type2 |
Scope | Bacteria |
Templates | P0AGJ9 (SYY_ECOLI); P00952 (SYY_GEOSE); P41256 (SYY_ACIFR); Q57834 (SYY_METJA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). |
Catalytic activity | RHEA:10220: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)
EC 6.1.1.1 |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. |
Keywords
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Gene Ontology
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GO:0004831; Molecular function: tyrosine-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006437; Biological process: tyrosyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
GO:0005524; Molecular function: ATP binding.
GO:0006437; Biological process: tyrosyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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PROSITE | PS00178; AA_TRNA_LIGASE_I; 1; |
PS50889; S4; 1; trigger=PRU00182; | |
Pfam | PF01479; S4; 1; |
PF00579; tRNA-synt_1b; 1; | |
PRINTS | PR01040; TRNASYNTHTYR; 1; |
TIGRFAMs | TIGR00234; TyrS; 1; |
Features
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From: SYY_ACIFR (P41256) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | 47 | 56 | 'HIGH' region | P-[TS]-[ARGS]-[PASTRK]-[DEN]-[LIV]-[HT]-[LIV]-G-[HA] | ||||||||
MOTIF | 231 | 235 | 'KMSKS' region | K-M-S-K-[ST] | ||||||||
BINDING | 234 | 234 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K |
Additional information
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Size range | 392-432 amino acids |
Related rules | MF_02006 (SYY); MF_02008 (SYY) |
Fusion | None |
Comments | Some species have a second copy of TyrRS in another subfamily (MF_02006). |