HAMAP rule MF_02008
General rule information
[?]
Accession | MF_02008 |
Dates | 30-MAY-2006 (Created) 1-JUN-2023 (Last updated, Version 16) |
Name | Tyr_tRNA_synth_type3 |
Scope | Archaea; Euryarchaeota |
Templates | P0AGJ9 (SYY_ECOLI); P00952 (SYY_GEOSE); P41256 (SYY_ACIFR); Q57834 (SYY_METJA); O29482 (SYY_ARCFU); Q9YA64 (SYY_AERPE); O58739 (SYY_PYRHO): [Recover all] |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
Function | Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). |
Catalytic activity | RHEA:10220: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)
EC 6.1.1.1 |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily. |
Keywords
[?]
Gene Ontology
[?]
GO:0004831; Molecular function: tyrosine-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006437; Biological process: tyrosyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
GO:0005524; Molecular function: ATP binding.
GO:0006437; Biological process: tyrosyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
Cross-references
[?]
PROSITE | PS00178; AA_TRNA_LIGASE_I; 1; |
Pfam | PF00579; tRNA-synt_1b; 1; |
PRINTS | PR01040; TRNASYNTHTYR; 1; |
NCBIfam | TIGR00234; TyrS; 1; |
Features
[?]
From: SYY_METJA (Q57834) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | 37 | 45 | 'HIGH' region | P-[ST]-G-[KERV]-[IVML]-H-[LMI]-G-H | ||||||||
MOTIF | 204 | 208 | 'KMSKS' region | K-M-[SA]-S-S | ||||||||
BINDING | 32 | 32 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 | Y | ||||||||
BINDING | 151 | 151 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 | Y | ||||||||
BINDING | 155 | 155 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 | Q | ||||||||
BINDING | 158 | 158 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 | D | ||||||||
BINDING | 173 | 173 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 | Q |
case <FT:2>
end case
Additional information
[?]
Size range | 306-346 amino acids |
Related rules | MF_02006 (SYY); MF_02007 (SYY); MF_02009 (SYY) |
Fusion | None |