HAMAP rule MF_02008
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_02008 |
| Accession | MF_02008 |
| Dates | 30-MAY-2006 (Created)
8-OCT-2024 (Last updated, Version 18) |
| Name | Tyr_tRNA_synth_type3 |
| Scope(s) |
Archaea Methanobacteriati |
| Template(s) | P0AGJ9 (SYY_ECOLI); P00952 (SYY_GEOSE); P41256 (SYY_ACIFR); Q57834 (SYY_METJA); O29482 (SYY_ARCFU); Q9YA64 (SYY_AERPE); O58739 (SYY_PYRHO); [ Recover all ] |
| Triggered by |
HAMAP; MF_02008 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SYY |
| Protein name | RecName: Full=Tyrosine--tRNA ligase; EC=6.1.1.1; AltName: Full=Tyrosyl-tRNA synthetase; Short=TyrRS; |
| Gene name | Name=tyrS; |
Comments
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| FUNCTION | Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). |
| CATALYTIC ACTIVITY | Reaction=tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+); Xref=Rhea:RHEA:10220, Rhea:RHEA-COMP:9706, Rhea:RHEA-COMP:9707, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58315, ChEBI:CHEBI:78442, ChEBI:CHEBI:78536, ChEBI:CHEBI:456215; EC=6.1.1.1; |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily. |
Keywords
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Gene Ontology
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| GO:0004831; Molecular function:tyrosine-tRNA ligase activity |
| GO:0005524; Molecular function:ATP binding |
| GO:0006437; Biological process:tyrosyl-tRNA aminoacylation |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| PROSITE | PS00178; AA_TRNA_LIGASE_I; 1; |
| Pfam | PF00579; tRNA-synt_1b; 1; |
| PRINTS | PR01040; TRNASYNTHTYR; 1; |
| NCBIfam | TIGR00234; TyrS; 1; |
Features
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| From: SYY_METJA (Q57834) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 37 | 45 | /note="'HIGH' region" | P-[ST]-G-[KERV]-[IVML]-H-[LMI]-G-H | ||||||||
| MOTIF | 204 | 208 | /note="'KMSKS' region" | K-M-[SA]-S-S | ||||||||
| BINDING | 32 | 32 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315" |
Y | ||||||||
| BINDING | 151 | 151 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315" |
Y | ||||||||
| BINDING | 155 | 155 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315" |
Q | ||||||||
| BINDING | 158 | 158 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315" |
D | ||||||||
| BINDING | 173 | 173 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315" |
Q | ||||||||
| case <FT:2> | ||||||||||||
| BINDING | 207 | 207 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
S | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 306-346 amino acids |
| Related rules |
MF_02006 MF_02007 MF_02009 |
| Fusion | Nter: None Cter: None |