HAMAP rule MF_02009
General rule information
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Accession | MF_02009 |
Dates | 30-MAY-2006 (Created) 1-JUN-2023 (Last updated, Version 16) |
Name | Tyr_tRNA_synth_type4 |
Scope | Archaea; Thermoproteota
Archaea; Euryarchaeota
Archaea; Nanoarchaeota |
Templates | P0AGJ9 (SYY_ECOLI); P00952 (SYY_GEOSE); P41256 (SYY_ACIFR); Q57834 (SYY_METJA); O29482 (SYY_ARCFU); Q9YA64 (SYY_AERPE); O58739 (SYY_PYRHO): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). |
Catalytic activity | RHEA:10220: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)
EC 6.1.1.1 |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. |
Keywords
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Gene Ontology
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GO:0004831; Molecular function: tyrosine-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006437; Biological process: tyrosyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
GO:0005524; Molecular function: ATP binding.
GO:0006437; Biological process: tyrosyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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PROSITE | PS00178; AA_TRNA_LIGASE_I; 1; |
Pfam | PF00579; tRNA-synt_1b; 1; |
PRINTS | PR01040; TRNASYNTHTYR; 1; |
NCBIfam | TIGR00234; TyrS; 1; |
Features
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From: SYY_AERPE (Q9YA64) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | 238 | 242 | 'KMSKS' region | K-M-S-K-S | ||||||||
BINDING | 39 | 39 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 | Y | ||||||||
BINDING | 165 | 165 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 | Y | ||||||||
BINDING | 169 | 169 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 | Q | ||||||||
BINDING | 172 | 172 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 | D | ||||||||
BINDING | 187 | 187 | /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 | Q | ||||||||
BINDING | 241 | 241 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K |
Additional information
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Size range | 316-376 amino acids |
Related rules | MF_02006 (SYY); MF_02007 (SYY); MF_02008 (SYY) |
Fusion | None |