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Annotation rule MF_02009
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General rule information [?]

Accession MF_02009
Dates 30-MAY-2006 (Created)
20-NOV-2019 (Last updated, Version 12)
Name Tyr_tRNA_synth_type4
Scope
Archaea; Crenarchaeota
Archaea; Euryarchaeota
Archaea; Nanoarchaeota
Templates P0AGJ9 (SYY_ECOLI); P00952 (SYY_GEOSE); P41256 (SYY_ACIFR); Q57834 (SYY_METJA); O29482 (SYY_ARCFU); Q9YA64 (SYY_AERPE); O58739 (SYY_PYRHO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SYY
Protein name
RecName: Full=Tyrosine--tRNA ligase;
EC 6.1.1.1;
AltName: Full=Tyrosyl-tRNA synthetase;
Short=TyrRS;
Gene name
tyrS

Comments [?]

Function Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Catalytic activity RHEA:10220: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)
EC 6.1.1.1
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.

Keywords [?]

Cytoplasm
Aminoacyl-tRNA synthetase
ATP-binding
Ligase
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

GO:0004831; Molecular function: tyrosine-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006437; Biological process: tyrosyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00178; AA_TRNA_LIGASE_I; 1;
Pfam PF00579; tRNA-synt_1b; 1;
PRINTS PR01040; TRNASYNTHTYR; 1;
TIGRFAMs TIGR00234; TyrS; 1;

Features [?]

From: SYY_AERPE (Q9YA64)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     238     242       'KMSKS' region     K-M-S-K-S  
BINDING     39     39       Tyrosine     Y  
BINDING     165     165       Tyrosine     Y  
BINDING     169     169       Tyrosine     Q  
BINDING     172     172       Tyrosine     D  
BINDING     187     187       Tyrosine     Q  
BINDING     241     241       ATP     K  

Additional information [?]

Size range 316-376 amino acids
Related rules MF_02006 (SYY); MF_02007 (SYY); MF_02008 (SYY)
Fusion None


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