HAMAP rule MF_02009

General rule information [?]

Accession	MF_02009
Dates	30-MAY-2006 (Created) 1-JUN-2023 (Last updated, Version 16)

Name	Tyr_tRNA_synth_type4

Scope

Archaea; Thermoproteota

Archaea; Euryarchaeota

Archaea; Nanoarchaeota

Templates

P0AGJ9 (SYY_ECOLI); P00952 (SYY_GEOSE); P41256 (SYY_ACIFR); Q57834 (SYY_METJA); O29482 (SYY_ARCFU); Q9YA64 (SYY_AERPE); O58739 (SYY_PYRHO): [Recover all]

Triggered by

HAMAP; MF_02009 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

SYY

Protein name

RecName:		Full=Tyrosine--tRNA ligase;
		EC 6.1.1.1;
AltName:		Full=Tyrosyl-tRNA synthetase;
		Short=TyrRS;

Gene name

tyrS

Comments [?]

Function	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Catalytic activity	RHEA:10220: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr) EC 6.1.1.1
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.

Keywords [?]

Cytoplasm
Aminoacyl-tRNA synthetase
ATP-binding
Ligase
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

GO:0004831; Molecular function: tyrosine-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006437; Biological process: tyrosyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE	PS00178; AA_TRNA_LIGASE_I; 1;
Pfam	PF00579; tRNA-synt_1b; 1;
PRINTS	PR01040; TRNASYNTHTYR; 1;
NCBIfam	TIGR00234; TyrS; 1;

Features [?]

From: SYY_AERPE (Q9YA64)

Key From To Description Tag Condition FTGroup

MOTIF 238 242 'KMSKS' region K-M-S-K-S

BINDING 39 39 /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 Y

BINDING 165 165 /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 Y

BINDING 169 169 /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 Q

BINDING 172 172 /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 D

BINDING 187 187 /ligand="L-tyrosine" /ligand_id="ChEBI:CHEBI:58315 Q

BINDING 241 241 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 K

Additional information [?]

Size range	316-376 amino acids
Related rules	MF_02006 (SYY); MF_02007 (SYY); MF_02008 (SYY)
Fusion	None

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