HAMAP rule MF_02009

General rule information [?]

Accession	MF_02009
Dates	30-MAY-2006 (Created) 8-OCT-2024 (Last updated, Version 18)
Name	Tyr_tRNA_synth_type4
Scope(s)	Archaea Thermoproteota Methanobacteriati Nanobdellota
Template(s)	P0AGJ9 (SYY_ECOLI); P00952 (SYY_GEOSE); P41256 (SYY_ACIFR); Q57834 (SYY_METJA); O29482 (SYY_ARCFU); Q9YA64 (SYY_AERPE); O58739 (SYY_PYRHO); [ Recover all ]
Triggered by	HAMAP; MF_02009 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SYY
Protein name	RecName: Full=Tyrosine--tRNA ligase; EC=6.1.1.1; AltName: Full=Tyrosyl-tRNA synthetase; Short=TyrRS;
Gene name	Name=tyrS;

Comments [?]

FUNCTION	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
CATALYTIC ACTIVITY	Reaction=tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+); Xref=Rhea:RHEA:10220, Rhea:RHEA-COMP:9706, Rhea:RHEA-COMP:9707, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58315, ChEBI:CHEBI:78442, ChEBI:CHEBI:78536, ChEBI:CHEBI:456215; EC=6.1.1.1;
SUBUNIT	Homodimer.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004831; Molecular function:tyrosine-tRNA ligase activity

GO:0005524; Molecular function:ATP binding

GO:0006437; Biological process:tyrosyl-tRNA aminoacylation

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: SYY_AERPE (Q9YA64)

Key

From

Description

Tag

Condition

FTGroup

MOTIF

238

242

/note="'KMSKS' region"

K-M-S-K-S

BINDING