Home  |  Contact
Annotation rule MF_02016
Send feedback

General rule information [?]

Accession MF_02016
Dates 15-OCT-2008 (Created)
20-NOV-2019 (Last updated, Version 13)
Name MltF
Bacteria; Proteobacteria
Template P0AGC5 (MLTF_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Membrane-bound lytic murein transglycosylase F;
EC 4.2.2.n1;
AltName: Full=Murein lyase F;
Flags: Precursor;
Gene name

Comments [?]

Function Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
Catalytic activity Reaction=Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n1;
Subcellular location Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Domain The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.
Similarity In the N-terminal section; belongs to the bacterial solute-binding protein 3 family.
In the C-terminal section; belongs to the transglycosylase Slt family.

Keywords [?]

Gene Ontology [?]

GO:0016998; Biological process: cell wall macromolecule catabolic process.
GO:0008933; Molecular function: lytic transglycosylase activity.
GO:0009279; Cellular component: cell outer membrane.

Cross-references [?]

Pfam PF00497; SBP_bac_3; 1;
PF01464; SLT; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
REGION     22     269       Non-LT domain        
REGION     270     Cter       LT domain        
ACT_SITE     314     314             E  

Additional information [?]

Size range 450-537 amino acids
Related rules None
Fusion None