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HAMAP rule MF_02016
General rule information
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| Accession | MF_02016 |
| Dates | 15-OCT-2008 (Created)
26-JAN-2023 (Last updated, Version 14) |
| Name | MltF |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P0AGC5 (MLTF_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_02016 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MLTF |
| Protein name | RecName: Full=Membrane-bound lytic murein transglycosylase F; EC=4.2.2.n1; AltName: Full=Murein lyase F; Flags: Precursor; |
| Gene name | Name=mltF; |
Comments
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| FUNCTION | Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. |
| CATALYTIC ACTIVITY | Reaction=Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n1; |
| SUBCELLULAR LOCATION | Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane. |
| DOMAIN | The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain. |
| SIMILARITY | In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. |
| SIMILARITY | In the C-terminal section; belongs to the transglycosylase Slt family. |
Keywords
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Gene Ontology
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| GO:0016998; Biological process:cell wall macromolecule catabolic process |
| GO:0008933; Molecular function:lytic transglycosylase activity |
| GO:0009279; Cellular component:cell outer membrane |
Cross-references
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| PROSITE | PS00922; TRANSGLYCOSYLASE; 1; |
| Pfam | PF00497; SBP_bac_3; 1; |
| Pfam | PF01464; SLT; 1; |
| General | Signal; -; 1; |
Features
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| From: MLTF_ECOLI (P0AGC5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 22 | 269 | /note="Non-LT domain" | |||||||||
| REGION | 270 | Cter | /note="LT domain" | |||||||||
| ACT_SITE | 314 | 314 | E | |||||||||
Additional information
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| Size range | 450-537 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |