HAMAP rule MF_02019
General rule information
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| Accession | MF_02019 |
| Dates | 16-FEB-2015 (Created) 19-NOV-2022 (Last updated, Version 7) |
| Name | MurF |
| Scope | Bacteria |
| Templates | P11880 (MURF_ECOLI); Q2FWH4 (MURF_STAA8): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. |
case <OC:Lactobacillales> or <OC:Staphylococcus>
| Catalytic activity | RHEA:16085: ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
EC 6.3.2.10 |
else
| Catalytic activity | RHEA:28374: ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
EC 6.3.2.10 |
end case
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the MurCDEF family. MurF subfamily. |
Keywords
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ATP-binding
Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Ligase
Nucleotide-binding
Peptidoglycan synthesis
Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Ligase
Nucleotide-binding
Peptidoglycan synthesis
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0047480; Molecular function: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0047480; Molecular function: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF01225; Mur_ligase; 1; |
| PF02875; Mur_ligase_C; 1; | |
| PF08245; Mur_ligase_M; 1; | |
| TIGRFAMs | TIGR01143; murF; 1; |
Features
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| From: MURF_ECOLI (P11880) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 107 | 113 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-[ST]-x-G-K-T-[ST] | ||||||||
Additional information
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| Size range | 420-535 amino acids |
| Related rules | None |
| Fusion | None |