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Annotation rule MF_02019
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General rule information [?]

Accession MF_02019
Dates 16-FEB-2015 (Created)
13-JAN-2021 (Last updated, Version 4)
Name MurF
Scope
Bacteria
Template P11880 (MURF_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MURF
Protein name
RecName: Full=UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase;
EC 6.3.2.10;
AltName: Full=D-alanyl-D-alanine-adding enzyme;
Gene name
murF

Comments [?]

Function Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
case <OC:Lactobacillales> or <OC:Staphylococcus>
Catalytic activity RHEA:16085: ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
EC 6.3.2.10
else
Catalytic activity RHEA:28374: ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
EC 6.3.2.10
end case
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location Cytoplasm.
Similarity Belongs to the MurCDEF family. MurF subfamily.

Keywords [?]

ATP-binding
Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Ligase
Nucleotide-binding
Peptidoglycan synthesis

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0047480; Molecular function: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01225; Mur_ligase; 1;
PF02875; Mur_ligase_C; 1;
PF08245; Mur_ligase_M; 1;
TIGRFAMs TIGR01143; murF; 1;

Features [?]

From: MURF_ECOLI (P11880)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     107     113       ATP     G-[ST]-x-G-K-T-[ST]  

Additional information [?]

Size range 420-535 amino acids
Related rules None
Fusion None


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