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HAMAP rule MF_02019

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General rule information [?]

Accession MF_02019
Dates 16-FEB-2015 (Created)
1-JUN-2023 (Last updated, Version 8)
Name MurF
Scope(s) Bacteria
Template(s) P11880 (MURF_ECOLI); Q2FWH4 (MURF_STAA8); [ Recover all ]
Triggered by HAMAP; MF_02019 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MURF
Protein name RecName: Full=UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase;
AltName: Full=D-alanyl-D-alanine-adding enzyme;
Gene name Name=murF;

Comments [?]

FUNCTIONInvolved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
case <OC:Lactobacillales> or <OC:Staphylococcus>
CATALYTIC ACTIVITY Reaction=ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-gamma-D-glutamyl-L-lysine = ADP + H(+) + phosphate + UDP-N- acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D- alanine; Xref=Rhea:RHEA:16085, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57822, ChEBI:CHEBI:70758, ChEBI:CHEBI:83903, ChEBI:CHEBI:456216; EC=;
CATALYTIC ACTIVITY Reaction=ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl- meso-2,6-diaminopimeloyl-D-alanyl-D-alanine; Xref=Rhea:RHEA:28374, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57822, ChEBI:CHEBI:61386, ChEBI:CHEBI:83905, ChEBI:CHEBI:456216; EC=;
end case
PATHWAYCell wall biogenesis; peptidoglycan biosynthesis.
SIMILARITYBelongs to the MurCDEF family. MurF subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0047480; Molecular function:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GO:0009252; Biological process:peptidoglycan biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01225; Mur_ligase; 1;
Pfam PF02875; Mur_ligase_C; 1;
Pfam PF08245; Mur_ligase_M; 1;
NCBIfam TIGR01143; murF; 1;

Features [?]

From: MURF_ECOLI (P11880)
Key From To Description Tag Condition FTGroup
BINDING 107 113 /ligand="ATP"

Additional information [?]

Size range 420-535 amino acids
Related rules None
Fusion Nter: None Cter: None

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