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Annotation rule MF_02020
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General rule information [?]

Accession MF_02020
Dates 17-FEB-2015 (Created)
21-JAN-2020 (Last updated, Version 4)
Name Mpl
Bacteria; Proteobacteria
Template P37773 (MPL_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase;
AltName: Full=Murein peptide ligase;
AltName: Full=UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase;
Gene name

Comments [?]

Function Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.
Catalytic activity RHEA:29563: ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
Cofactor Mg(2+)
Pathway Cell wall biogenesis; peptidoglycan recycling.
Similarity Belongs to the MurCDEF family. Mpl subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0016881; Molecular function: acid-amino acid ligase activity.
GO:0009254; Biological process: peptidoglycan turnover.

Cross-references [?]

Pfam PF01225; Mur_ligase; 1;
PF02875; Mur_ligase_C; 1;
PF08245; Mur_ligase_M; 1;
TIGRFAMs TIGR01081; mpl; 1;

Features [?]

From: MPL_ECOLI (P37773)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     110     116       ATP     G-[ST]-x-G-K-T-[ST]  

Additional information [?]

Size range 435-505 amino acids
Related rules None
Fusion None