HAMAP rule MF_02020
General rule information
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Accession | MF_02020 |
Dates | 17-FEB-2015 (Created)
1-JUN-2023 (Last updated, Version 8) |
Name | Mpl |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P37773 (MPL_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_02020 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MPL |
Protein name | RecName: Full=UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase; EC=6.3.2.45; AltName: Full=Murein peptide ligase; AltName: Full=UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase; |
Gene name | Name=mpl; |
Comments
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FUNCTION | Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. |
CATALYTIC ACTIVITY | Reaction=ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N- acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate; Xref=Rhea:RHEA:29563, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:61401, ChEBI:CHEBI:70757, ChEBI:CHEBI:83905, ChEBI:CHEBI:456216; EC=6.3.2.45; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
PATHWAY | Cell wall biogenesis; peptidoglycan recycling. |
SIMILARITY | Belongs to the MurCDEF family. Mpl subfamily. |
Keywords
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ATP-binding |
Cell cycle |
Cell division |
Cell shape |
Cell wall biogenesis/degradation |
Ligase |
Magnesium |
Nucleotide-binding |
Peptidoglycan synthesis |
Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0016881; Molecular function:acid-amino acid ligase activity |
GO:0009254; Biological process:peptidoglycan turnover |
Cross-references
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Pfam | PF01225; Mur_ligase; 1; |
Pfam | PF02875; Mur_ligase_C; 1; |
Pfam | PF08245; Mur_ligase_M; 1; |
NCBIfam | TIGR01081; mpl; 1; |
Features
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From: MPL_ECOLI (P37773) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 110 | 116 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-[ST]-x-G-K-T-[ST] |
Additional information
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Size range | 435-505 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |