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HAMAP rule MF_02020

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General rule information [?]

Accession MF_02020
Dates 17-FEB-2015 (Created)
1-JUN-2023 (Last updated, Version 8)
Name Mpl
Scope(s) Bacteria
Template(s) P37773 (MPL_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02020 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MPL
Protein name RecName: Full=UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase;
AltName: Full=Murein peptide ligase;
AltName: Full=UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase;
Gene name Name=mpl;

Comments [?]

FUNCTIONReutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate.
CATALYTIC ACTIVITY Reaction=ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N- acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate; Xref=Rhea:RHEA:29563, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:61401, ChEBI:CHEBI:70757, ChEBI:CHEBI:83905, ChEBI:CHEBI:456216; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAYCell wall biogenesis; peptidoglycan recycling.
SIMILARITYBelongs to the MurCDEF family. Mpl subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0016881; Molecular function:acid-amino acid ligase activity
GO:0009254; Biological process:peptidoglycan turnover

Cross-references [?]

Pfam PF01225; Mur_ligase; 1;
Pfam PF02875; Mur_ligase_C; 1;
Pfam PF08245; Mur_ligase_M; 1;
NCBIfam TIGR01081; mpl; 1;

Features [?]

From: MPL_ECOLI (P37773)
Key From To Description Tag Condition FTGroup
BINDING 110 116 /ligand="ATP"

Additional information [?]

Size range 435-505 amino acids
Related rules None
Fusion Nter: None Cter: None

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