HAMAP rule MF_02020
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_02020 |
| Accession | MF_02020 |
| Dates | 17-FEB-2015 (Created)
17-DEC-2024 (Last updated, Version 11) |
| Name | Mpl |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P37773; [ Recover all ] |
| Triggered by |
HAMAP; MF_02020 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | MPL |
| Protein name | RecName: Full=UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase; EC=6.3.2.45; AltName: Full=Murein peptide ligase; AltName: Full=UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase; |
| Gene name | Name=mpl; |
Comments
[?]
| FUNCTION | Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. |
| CATALYTIC ACTIVITY | Reaction=UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl- meso-2,6-diaminopimelate + ATP = UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate + ADP + phosphate + H(+); Xref=Rhea:RHEA:29563, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:61401, ChEBI:CHEBI:70757, ChEBI:CHEBI:83905, ChEBI:CHEBI:456216; EC=6.3.2.45; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Cell wall biogenesis; peptidoglycan recycling. |
| SIMILARITY | Belongs to the MurCDEF family. Mpl subfamily. |
Keywords
[?]
| ATP-binding |
| Cell cycle |
| Cell division |
| Cell shape |
| Cell wall biogenesis/degradation |
| Ligase |
| Magnesium |
| Nucleotide-binding |
| Peptidoglycan synthesis |
Gene Ontology
[?]
| GO:0005524; Molecular function:ATP binding |
| GO:0016881; Molecular function:acid-amino acid ligase activity |
| GO:0009254; Biological process:peptidoglycan turnover |
Cross-references
[?]
| Pfam | PF01225; Mur_ligase; 1; |
| Pfam | PF02875; Mur_ligase_C; 1; |
| Pfam | PF08245; Mur_ligase_M; 1; |
| NCBIfam | TIGR01081; mpl; 1; |
Features
[?]
| From: MPL_ECOLI (P37773) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 110 | 116 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-[ST]-x-G-K-T-[ST] | ||||||||
Additional information
[?]
| Size range | 435-505 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |