HAMAP rule MF_02026
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_02026 |
| Accession | MF_02026 |
| Dates | 21-APR-2015 (Created)
3-SEP-2024 (Last updated, Version 8) |
| Name | WecE_RffA |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P27833 (WECE_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_02026 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | WECE |
| Protein name | RecName: Full=dTDP-4-amino-4,6-dideoxygalactose transaminase; EC=2.6.1.59; |
| Gene name | Name=wecE; |
Comments
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| FUNCTION | Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate. |
| CATALYTIC ACTIVITY | Reaction=dTDP-4-amino-4,6-dideoxy-alpha-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate; Xref=Rhea:RHEA:10368, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57649, ChEBI:CHEBI:68492; EC=2.6.1.59; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| PATHWAY | Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. |
| SIMILARITY | Belongs to the DegT/DnrJ/EryC1 family. |
Keywords
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Gene Ontology
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| GO:0019180; Molecular function:dTDP-4-amino-4,6-dideoxygalactose transaminase activity |
| GO:0030170; Molecular function:pyridoxal phosphate binding |
| GO:0009246; Biological process:enterobacterial common antigen biosynthetic process |
Cross-references
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| Pfam | PF01041; DegT_DnrJ_EryC1; 1; |
| NCBIfam | TIGR02379; ECA_wecE; 1; |
| PIRSF | PIRSF000390; PLP_StrS; 1; |
Features
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| From: WECE_ECOLI (P27833) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 181 | 181 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 360-392 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |