HAMAP rule MF_02027

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02027
Accession	MF_02027
Dates	22-APR-2015 (Created) 03-SEP-2024 (Last updated, Version 11)
Name	WecD_RffC
Scope(s)	Bacteria Enterobacterales
Template(s)	Q8FBQ3; [ Recover all ]
Triggered by	HAMAP; MF_02027 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	WECD
Protein name	RecName: Full=dTDP-fucosamine acetyltransferase; EC=2.3.1.210; AltName: Full=TDP-fucosamine acetyltransferase; AltName: Full=dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
Gene name	Name=wecD;

Comments [?]

FUNCTION	Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).
CATALYTIC ACTIVITY	Reaction=dTDP-4-amino-4,6-dideoxy-alpha-D-galactose + acetyl-CoA = dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + CoA + H(+); Xref=Rhea:RHEA:34443, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:68492, ChEBI:CHEBI:68493; EC=2.3.1.210;
PATHWAY	Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the WecD family.

Keywords [?]

Gene Ontology [?]

GO:0016747; Molecular function:acyltransferase activity, transferring groups other than amino-acyl groups

GO:0009246; Biological process:enterobacterial common antigen biosynthetic process

Cross-references [?]

Features [?]

From: WECD_ECOL6 (Q8FBQ3)

Key

From

Description

Tag

Condition

FTGroup

BINDING

168

174

/ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"

ACT_SITE

208

/note="Proton donor"

BINDING

201

/ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"

BINDING

207

/ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"

Additional information [?]