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HAMAP rule MF_02027

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General rule information [?]

Accession MF_02027
Dates 22-APR-2015 (Created)
19-NOV-2022 (Last updated, Version 8)
Name WecD_RffC
Bacteria; Enterobacterales
Template Q8FBQ3 (WECD_ECOL6)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=dTDP-fucosamine acetyltransferase;
AltName: Full=TDP-fucosamine acetyltransferase;
AltName: Full=dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
Gene name

Comments [?]

Function Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).
Catalytic activity RHEA:34443: acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)
Pathway Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
Subunit Homodimer.
Similarity Belongs to the WecD family.

Keywords [?]

Gene Ontology [?]

GO:0016747; Molecular function: acyltransferase activity, transferring groups other than amino-acyl groups.
GO:0009246; Biological process: enterobacterial common antigen biosynthetic process.

Cross-references [?]

PROSITE PS51186; GNAT; 1; trigger=PRU00532;
Pfam PF00583; Acetyltransf_1; 1;
TIGRFAMs TIGR02382; wecD_rffC; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     168     174       /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288        
ACT_SITE     208     208       Proton donor     Y  
BINDING     201     201       /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288     N  
BINDING     207     207       /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288     R  

Additional information [?]

Size range 180-260 amino acids
Related rules None
Fusion None