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Annotation rule MF_02029
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General rule information [?]

Accession MF_02029
Dates 11-MAY-2015 (Created)
20-NOV-2019 (Last updated, Version 6)
Name WecC_RffD
Scope
Bacteria; Enterobacterales
Template P27829 (WECC_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
WECC
Protein name
RecName: Full=UDP-N-acetyl-D-mannosamine dehydrogenase;
EC 1.1.1.336;
AltName: Full=UDP-ManNAc 6-dehydrogenase;
Gene name
wecC

Comments [?]

Function Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
Catalytic activity RHEA:25780: H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate
EC 1.1.1.336
Subunit Homodimer.
Pathway Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
Similarity Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily.

Keywords [?]


Gene Ontology [?]

GO:0089714; Molecular function: UDP-N-acetyl-D-mannosamine dehydrogenase activity.
GO:0009246; Biological process: enterobacterial common antigen biosynthetic process.

Cross-references [?]

Pfam PF00984; UDPG_MGDP_dh; 1;
PF03720; UDPG_MGDP_dh_C; 1;
PF03721; UDPG_MGDP_dh_N; 1;
TIGRFAMs TIGR03026; NDP-sugDHase; 1;
PIRSF PIRSF500136; UDP_ManNAc_DH; 1;
PIRSF000124; UDPglc_GDPman_dh; 1;

Features [?]

From: WECC_ECOLI (P27829)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     10     15       NAD     G-L-G-Y-I-G  
REGION     160     161       Substrate binding     R-V  
REGION     216     219       Substrate binding     N-x-x-R  
REGION     250     252       Substrate binding; shared with dimeric partner     H-x-R  
REGION     330     331       Substrate binding     [FY]-K  
ACT_SITE     212     212       Proton donor/acceptor     K  
ACT_SITE     266     266       Nucleophile     C  
BINDING     212     212       Substrate     K  
BINDING     263     263       Substrate; via amide nitrogen     G  

Additional information [?]

Size range 418-445 amino acids
Related rules None
Fusion None