HAMAP rule MF_02032

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02032
Accession	MF_02032
Dates	26-MAY-2015 (Created) 03-SEP-2024 (Last updated, Version 9)
Name	Tartronate_sem_reduc
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	P0ABQ2; [ Recover all ]
Triggered by	HAMAP; MF_02032 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GARR
Protein name	RecName: Full=2-hydroxy-3-oxopropionate reductase; EC=1.1.1.60; AltName: Full=Tartronate semialdehyde reductase; Short=TSAR;
Gene name	Name=garR;

Comments [?]

FUNCTION	Catalyzes the reduction of tatronate semialdehyde to D- glycerate.
CATALYTIC ACTIVITY	Reaction=(R)-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + NADPH + H(+); Xref=Rhea:RHEA:18841, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659, ChEBI:CHEBI:57783, ChEBI:CHEBI:57978, ChEBI:CHEBI:58349; EC=1.1.1.60;
CATALYTIC ACTIVITY	Reaction=(R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + NADH + H(+); Xref=Rhea:RHEA:18845, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57978; EC=1.1.1.60;
PATHWAY	Carbohydrate acid metabolism; galactarate degradation; D- glycerate from galactarate: step 3/3.
SIMILARITY	Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008679; Molecular function:2-hydroxy-3-oxopropionate reductase activity

GO:0046392; Biological process:galactarate catabolic process

Cross-references [?]

Features [?]

From: GARR_ECOLI (P0ABQ2)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"

ACT_SITE

170

BINDING

/ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"

BINDING

238

/ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"

Additional information [?]