HAMAP rule MF_02032
General rule information
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| Accession | MF_02032 |
| Dates | 26-MAY-2015 (Created) 19-NOV-2022 (Last updated, Version 6) |
| Name | Tartronate_sem_reduc |
| Scope | Bacteria; Gammaproteobacteria |
| Template | P0ABQ2 (GARR_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the reduction of tatronate semialdehyde to D-glycerate. |
| Catalytic activity | RHEA:18841: (R)-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH
EC 1.1.1.60 |
| RHEA:18845: (R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH
EC 1.1.1.60 |
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| Pathway | Carbohydrate acid metabolism; galactarate degradation; D-glycerate from galactarate: step 3/3. |
| Similarity | Belongs to the HIBADH-related family. 2-hydroxy-3-oxopropionate reductase subfamily. |
Keywords
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Gene Ontology
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GO:0008679; Molecular function: 2-hydroxy-3-oxopropionate reductase activity.
GO:0046392; Biological process: galactarate catabolic process.
GO:0046392; Biological process: galactarate catabolic process.
Cross-references
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| PROSITE | PS00895; 3_HYDROXYISOBUT_DH; 1; |
| Pfam | PF14833; NAD_binding_11; 1; |
| PF03446; NAD_binding_2; 1; | |
| TIGRFAMs | TIGR01505; tartro_sem_red; 1; |
| PIRSF | PIRSF000103; HIBADH; 1; |
Features
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| From: GARR_ECOLI (P0ABQ2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 4 | 18 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | |||||||||
| ACT_SITE | 170 | 170 | K | |||||||||
| BINDING | 95 | 95 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | S | ||||||||
| BINDING | 238 | 238 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | K | ||||||||
Additional information
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| Size range | 276-302 amino acids |
| Related rules | None |
| Fusion | None |