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Annotation rule MF_02034
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General rule information [?]

Accession MF_02034
Dates 1-JUL-2015 (Created)
20-NOV-2019 (Last updated, Version 3)
Name EgtA
Scope
Bacteria; Actinobacteria
Templates P9WPK7 (EGTA_MYCTU); A0R5N1 (EGTA_MYCS2): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
EGTA
Protein name
RecName: Full=Glutamate--cysteine ligase EgtA;
EC 6.3.2.2;
AltName: Full=Gamma-glutamylcysteine synthase;
Short=GCS;
Short=Gamma-ECS;
Gene name
egtA

Comments [?]

Function Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.
Catalytic activity RHEA:13285: ATP + L-cysteine + L-glutamate = ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate
EC 6.3.2.2
Pathway Amino-acid biosynthesis; ergothioneine biosynthesis.
Similarity Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004357; Molecular function: glutamate-cysteine ligase activity.
GO:0052699; Biological process: ergothioneine biosynthetic process.

Cross-references [?]

Pfam PF04107; GCS2; 1;
TIGRFAMs TIGR03444; EgtA_Cys_ligase; 1;

Additional information [?]

Size range 380-502 amino acids
Related rules None
Fusion None