HAMAP rule MF_02034

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02034
Accession	MF_02034
Dates	01-JUL-2015 (Created) 03-SEP-2024 (Last updated, Version 8)
Name	EgtA
Scope(s)	Bacteria Actinomycetota
Template(s)	P9WPK7; A0R5N1; [ Recover all ]
Triggered by	HAMAP; MF_02034 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	EGTA
Protein name	RecName: Full=Glutamate--cysteine ligase EgtA; EC=6.3.2.2; AltName: Full=Gamma-glutamylcysteine synthase; Short=GCS; Short=Gamma-ECS;
Gene name	Name=egtA;

Comments [?]

FUNCTION	Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.
CATALYTIC ACTIVITY	Reaction=L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+); Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235, ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;
PATHWAY	Amino-acid biosynthesis; ergothioneine biosynthesis.
SIMILARITY	Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0004357; Molecular function:glutamate-cysteine ligase activity

GO:0052699; Biological process:ergothioneine biosynthetic process

Cross-references [?]

Pfam	PF04107; GCS2; 1;
NCBIfam	TIGR03444; EgtA_Cys_ligase; 1;

Features [?]

Additional information [?]