HAMAP rule MF_02034
General rule information
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Accession | MF_02034 |
Dates | 1-JUL-2015 (Created)
1-JUN-2023 (Last updated, Version 6) |
Name | EgtA |
Scope(s) |
Bacteria Actinomycetota |
Template(s) | P9WPK7 (EGTA_MYCTU); A0R5N1 (EGTA_MYCS2); [ Recover all ] |
Triggered by |
HAMAP; MF_02034 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | EGTA |
Protein name | RecName: Full=Glutamate--cysteine ligase EgtA; EC=6.3.2.2; AltName: Full=Gamma-glutamylcysteine synthase; Short=GCS; Short=Gamma-ECS; |
Gene name | Name=egtA; |
Comments
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FUNCTION | Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. |
CATALYTIC ACTIVITY | Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L- cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235, ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2; |
PATHWAY | Amino-acid biosynthesis; ergothioneine biosynthesis. |
SIMILARITY | Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0004357; Molecular function:glutamate-cysteine ligase activity |
GO:0052699; Biological process:ergothioneine biosynthetic process |
Cross-references
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Features
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Additional information
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Size range | 380-502 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |