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HAMAP rule MF_02034

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General rule information [?]

Accession MF_02034
Dates 1-JUL-2015 (Created)
1-JUN-2023 (Last updated, Version 6)
Name EgtA
Scope(s) Bacteria
Template(s) P9WPK7 (EGTA_MYCTU); A0R5N1 (EGTA_MYCS2); [ Recover all ]
Triggered by HAMAP; MF_02034 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier EGTA
Protein name RecName: Full=Glutamate--cysteine ligase EgtA;
AltName: Full=Gamma-glutamylcysteine synthase;
Gene name Name=egtA;

Comments [?]

FUNCTIONCatalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.
CATALYTIC ACTIVITY Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L- cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235, ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=;
PATHWAYAmino-acid biosynthesis; ergothioneine biosynthesis.
SIMILARITYBelongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004357; Molecular function:glutamate-cysteine ligase activity
GO:0052699; Biological process:ergothioneine biosynthetic process

Cross-references [?]

Pfam PF04107; GCS2; 1;
NCBIfam TIGR03444; EgtA_Cys_ligase; 1;

Features [?]

Additional information [?]

Size range 380-502 amino acids
Related rules None
Fusion Nter: None Cter: None

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