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Annotation rule MF_02035 |
Accession | MF_02035 |
Dates | 1-JUL-2015 (Created) 20-NOV-2019 (Last updated, Version 5) |
Name | EgtB |
Scope | Bacteria; Actinobacteria |
Templates | G7CFI3 (EGTB_MYCT3); A0R5N0 (EGTB_MYCS2): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. |
Catalytic activity | RHEA:42672: hercynine + L-gamma-glutamyl-L-cysteine + O2 = H2O + L-gamma-glutamyl-hercynylcysteine S-oxide
EC 1.14.99.50 |
Cofactor | Fe(2+) |
Pathway | Amino-acid biosynthesis; ergothioneine biosynthesis. |
Similarity | Belongs to the EgtB family. |
From: EGTB_MYCT3 (G7CFI3) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION (Optional) | 87 | 90 | Gamma-glutamylcysteine binding | R-x-x-R | ||||||||
METAL | 51 | 51 | Iron; via tele nitrogen | H | ||||||||
METAL | 134 | 134 | Iron; via tele nitrogen | H | ||||||||
METAL | 138 | 138 | Iron; via tele nitrogen | H | ||||||||
BINDING (Optional) | 416 | 416 | Gamma-glutamylcysteine | D | ||||||||
BINDING (Optional) | 420 | 420 | Gamma-glutamylcysteine | R |
Size range | 414-510 amino acids |
Related rules | None |
Fusion | None |