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Annotation rule MF_02035
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General rule information [?]

Accession MF_02035
Dates 1-JUL-2015 (Created)
20-NOV-2019 (Last updated, Version 5)
Name EgtB
Scope
Bacteria; Actinobacteria
Templates G7CFI3 (EGTB_MYCT3); A0R5N0 (EGTB_MYCS2): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
EGTB
Protein name
RecName: Full=Hercynine oxygenase;
EC 1.14.99.50;
AltName: Full=Gamma-glutamyl hercynylcysteine S-oxide synthase;
Gene name
egtB

Comments [?]

Function Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
Catalytic activity RHEA:42672: hercynine + L-gamma-glutamyl-L-cysteine + O2 = H2O + L-gamma-glutamyl-hercynylcysteine S-oxide
EC 1.14.99.50
Cofactor Fe(2+)
Pathway Amino-acid biosynthesis; ergothioneine biosynthesis.
Similarity Belongs to the EgtB family.

Keywords [?]

Iron
Metal-binding
Monooxygenase
Oxidoreductase

Gene Ontology [?]

GO:0005506; Molecular function: iron ion binding.
GO:0016705; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.
GO:0052699; Biological process: ergothioneine biosynthetic process.

Cross-references [?]

Pfam PF12867; DinB_2; 1;
PF03781; FGE-sulfatase; 1;
TIGRFAMs TIGR03440; egtB_TIGR03440; 1;

Features [?]

From: EGTB_MYCT3 (G7CFI3)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     87     90       Gamma-glutamylcysteine binding     R-x-x-R  
METAL     51     51       Iron; via tele nitrogen     H  
METAL     134     134       Iron; via tele nitrogen     H  
METAL     138     138       Iron; via tele nitrogen     H  
BINDING (Optional)     416     416       Gamma-glutamylcysteine     D  
BINDING (Optional)     420     420       Gamma-glutamylcysteine     R  

Additional information [?]

Size range 414-510 amino acids
Related rules None
Fusion None


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