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HAMAP rule MF_02035

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General rule information [?]

Accession MF_02035
Dates 1-JUL-2015 (Created)
1-JUN-2023 (Last updated, Version 11)
Name EgtB
Scope(s) Bacteria
Template(s) G7CFI3 (EGTB_MYCT3); A0R5N0 (EGTB_MYCS2); [ Recover all ]
Triggered by HAMAP; MF_02035 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier EGTB
Protein name RecName: Full=Hercynine oxygenase;
AltName: Full=Gamma-glutamyl hercynylcysteine S-oxide synthase;
Gene name Name=egtB;

Comments [?]

FUNCTIONCatalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
CATALYTIC ACTIVITY Reaction=gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L- glutamyl-hercynylcysteine S-oxide + H2O; Xref=Rhea:RHEA:42672, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:15781, ChEBI:CHEBI:58173, ChEBI:CHEBI:82703; EC=;
COFACTOR Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
PATHWAYAmino-acid biosynthesis; ergothioneine biosynthesis.
SIMILARITYBelongs to the EgtB family.

Keywords [?]

Gene Ontology [?]

GO:0005506; Molecular function:iron ion binding
GO:0016705; Molecular function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0052699; Biological process:ergothioneine biosynthetic process

Cross-references [?]

Pfam PF12867; DinB_2; 1;
Pfam PF03781; FGE-sulfatase; 1;
NCBIfam TIGR03440; egtB_TIGR03440; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 87 90 /ligand="gamma-L-glutamyl-L-cysteine"
BINDING 51 51 /ligand="Fe cation"
BINDING 134 134 /ligand="Fe cation"
BINDING 138 138 /ligand="Fe cation"
BINDING 416 416 /ligand="gamma-L-glutamyl-L-cysteine"
BINDING 420 420 /ligand="gamma-L-glutamyl-L-cysteine"

Additional information [?]

Size range 414-510 amino acids
Related rules None
Fusion Nter: None Cter: None

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