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HAMAP rule MF_02037

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General rule information [?]

Accession MF_02037
Dates 1-JUL-2015 (Created)
1-JUN-2023 (Last updated, Version 8)
Name EgtD
Scope(s) Bacteria
Actinomycetota
Template(s) A0R5M8 (EGTD_MYCS2); [ Recover all ]
Triggered by HAMAP; MF_02037 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier EGTD
Protein name RecName: Full=Histidine N-alpha-methyltransferase;
                 EC=2.1.1.44;
AltName: Full=Histidine trimethyltransferase;
Gene name Name=egtD;

Comments [?]

FUNCTIONCatalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.
CATALYTIC ACTIVITY Reaction=L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:38471, ChEBI:CHEBI:15378, ChEBI:CHEBI:15781, ChEBI:CHEBI:57595, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.44;
PATHWAYAmino-acid biosynthesis; ergothioneine biosynthesis.
SUBUNITMonomer.
SIMILARITYBelongs to the methyltransferase superfamily. EgtD family.

Keywords [?]


Gene Ontology [?]

GO:0030745; Molecular function:dimethylhistidine N-methyltransferase activity
GO:0052699; Biological process:ergothioneine biosynthetic process

Cross-references [?]

Pfam PF10017; Methyltransf_33; 1;
NCBIfam TIGR03438; egtD_ergothio; 1;
PIRSF PIRSF018005; UCP018005; 1;

Features [?]

From: EGTD_MYCS2 (A0R5M8)
Key From To Description Tag Condition FTGroup
BINDING 141 142 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
D-[FMLY]
BINDING 282 284 /ligand="L-histidine"
/ligand_id="ChEBI:CHEBI:57595"
E-[VI]-S
BINDING 56 56 /ligand="L-histidine"
/ligand_id="ChEBI:CHEBI:57595"
Y
BINDING 86 86 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
G
BINDING 92 92 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
K
BINDING 113 113 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
D
BINDING 166 166 /ligand="L-histidine"
/ligand_id="ChEBI:CHEBI:57595"
N
BINDING 206 206 /ligand="L-histidine"
/ligand_id="ChEBI:CHEBI:57595"
Y

Additional information [?]

Size range 311-400 amino acids
Related rules None
Fusion Nter: None Cter: None



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