HAMAP rule MF_02037
General rule information
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Accession | MF_02037 |
Dates | 1-JUL-2015 (Created)
1-JUN-2023 (Last updated, Version 8) |
Name | EgtD |
Scope(s) |
Bacteria Actinomycetota |
Template(s) | A0R5M8 (EGTD_MYCS2); [ Recover all ] |
Triggered by |
HAMAP; MF_02037 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | EGTD |
Protein name | RecName: Full=Histidine N-alpha-methyltransferase; EC=2.1.1.44; AltName: Full=Histidine trimethyltransferase; |
Gene name | Name=egtD; |
Comments
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FUNCTION | Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. |
CATALYTIC ACTIVITY | Reaction=L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:38471, ChEBI:CHEBI:15378, ChEBI:CHEBI:15781, ChEBI:CHEBI:57595, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.44; |
PATHWAY | Amino-acid biosynthesis; ergothioneine biosynthesis. |
SUBUNIT | Monomer. |
SIMILARITY | Belongs to the methyltransferase superfamily. EgtD family. |
Keywords
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Gene Ontology
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GO:0030745; Molecular function:dimethylhistidine N-methyltransferase activity |
GO:0052699; Biological process:ergothioneine biosynthetic process |
Cross-references
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Pfam | PF10017; Methyltransf_33; 1; |
NCBIfam | TIGR03438; egtD_ergothio; 1; |
PIRSF | PIRSF018005; UCP018005; 1; |
Features
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From: EGTD_MYCS2 (A0R5M8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 141 | 142 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D-[FMLY] | ||||||||
BINDING | 282 | 284 | /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595" |
E-[VI]-S | ||||||||
BINDING | 56 | 56 | /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595" |
Y | ||||||||
BINDING | 86 | 86 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
BINDING | 92 | 92 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
K | ||||||||
BINDING | 113 | 113 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
BINDING | 166 | 166 | /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595" |
N | ||||||||
BINDING | 206 | 206 | /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595" |
Y |
Additional information
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Size range | 311-400 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |