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| Annotation rule MF_02037 |
General rule information
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| Accession | MF_02037 |
| Dates | 1-JUL-2015 (Created) 20-NOV-2019 (Last updated, Version 3) |
| Name | EgtD |
| Scope | Bacteria; Actinobacteria |
| Template | A0R5M8 (EGTD_MYCS2) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. |
| Catalytic activity | RHEA:38471: L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine
EC 2.1.1.44 |
| Pathway | Amino-acid biosynthesis; ergothioneine biosynthesis. |
| Subunit | Monomer. |
| Similarity | Belongs to the methyltransferase superfamily. EgtD family. |
Keywords
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Gene Ontology
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GO:0030745; Molecular function: dimethylhistidine N-methyltransferase activity.
GO:0052699; Biological process: ergothioneine biosynthetic process.
GO:0052699; Biological process: ergothioneine biosynthetic process.
Cross-references
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| Pfam | PF10017; Methyltransf_33; 1; |
| TIGRFAMs | TIGR03438; egtD_ergothio; 1; |
| PIRSF | PIRSF018005; UCP018005; 1; |
Features
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| From: EGTD_MYCS2 (A0R5M8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 141 | 142 | S-adenosyl-L-methionine binding | D-[FMLY] | ||||||||
| REGION (Optional) | 282 | 284 | L-histidine binding | E-[VI]-S | ||||||||
| BINDING | 56 | 56 | L-histidine | Y | ||||||||
| BINDING | 86 | 86 | S-adenosyl-L-methionine; via carbonyl oxygen | G | ||||||||
| BINDING | 92 | 92 | S-adenosyl-L-methionine | K | ||||||||
| BINDING | 113 | 113 | S-adenosyl-L-methionine | D | ||||||||
| BINDING (Optional) | 166 | 166 | L-histidine | N | ||||||||
| BINDING (Optional) | 206 | 206 | L-histidine | Y | ||||||||
Additional information
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| Size range | 311-400 amino acids |
| Related rules | None |
| Fusion | None |