HAMAP rule MF_02037
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_02037 |
| Accession | MF_02037 |
| Dates | 1-JUL-2015 (Created)
4-SEP-2024 (Last updated, Version 10) |
| Name | EgtD |
| Scope(s) |
Bacteria Actinomycetota |
| Template(s) | A0R5M8 (EGTD_MYCS2); [ Recover all ] |
| Triggered by |
HAMAP; MF_02037 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | EGTD |
| Protein name | RecName: Full=Histidine N-alpha-methyltransferase; EC=2.1.1.44; AltName: Full=Histidine trimethyltransferase; |
| Gene name | Name=egtD; |
Comments
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| FUNCTION | Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. |
| CATALYTIC ACTIVITY | Reaction=L-histidine + 3 S-adenosyl-L-methionine = hercynine + 3 S- adenosyl-L-homocysteine + 3 H(+); Xref=Rhea:RHEA:38471, ChEBI:CHEBI:15378, ChEBI:CHEBI:15781, ChEBI:CHEBI:57595, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.44; |
| PATHWAY | Amino-acid biosynthesis; ergothioneine biosynthesis. |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the methyltransferase superfamily. EgtD family. |
Keywords
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Gene Ontology
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| GO:0052706; Molecular function:L-histidine N(alpha)-methyltransferase activity |
| GO:0052699; Biological process:ergothioneine biosynthetic process |
Cross-references
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| Pfam | PF10017; Methyltransf_33; 1; |
| NCBIfam | TIGR03438; egtD_ergothio; 1; |
| PIRSF | PIRSF018005; UCP018005; 1; |
Features
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| From: EGTD_MYCS2 (A0R5M8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 141 | 142 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D-[FMLY] | ||||||||
| BINDING | 282 | 284 | /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595" |
E-[VI]-S | ||||||||
| BINDING | 56 | 56 | /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595" |
Y | ||||||||
| BINDING | 86 | 86 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
| BINDING | 92 | 92 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
K | ||||||||
| BINDING | 113 | 113 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
| BINDING | 166 | 166 | /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595" |
N | ||||||||
| BINDING | 206 | 206 | /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595" |
Y | ||||||||
Additional information
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| Size range | 311-400 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |