HAMAP rule MF_02037

General rule information [?]

Accession	MF_02037
Dates	1-JUL-2015 (Created) 1-JUN-2023 (Last updated, Version 8)

Name

EgtD

Scope

Bacteria; Actinomycetota

Template

A0R5M8 (EGTD_MYCS2)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

EGTD

Protein name

RecName:		Full=Histidine N-alpha-methyltransferase;
		EC 2.1.1.44;
AltName:		Full=Histidine trimethyltransferase;

Gene name

egtD

Comments [?]

Function	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.
Catalytic activity	RHEA:38471: L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine EC 2.1.1.44
Pathway	Amino-acid biosynthesis; ergothioneine biosynthesis.
Subunit	Monomer.
Similarity	Belongs to the methyltransferase superfamily. EgtD family.

Keywords [?]

Gene Ontology [?]

GO:0030745; Molecular function: dimethylhistidine N-methyltransferase activity.
GO:0052699; Biological process: ergothioneine biosynthetic process.

Cross-references [?]

Features [?]

From: EGTD_MYCS2 (A0R5M8)

Key From To Description Tag Condition FTGroup

BINDING 141 142 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 D-[FMLY]

BINDING (Optional) 282 284 /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595 E-[VI]-S

BINDING 56 56 /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595 Y

BINDING 86 86 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 G

BINDING 92 92 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 K

BINDING 113 113 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 D

BINDING (Optional) 166 166 /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595 N

BINDING (Optional) 206 206 /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595 Y

Additional information [?]