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Annotation rule MF_02037 |
Accession | MF_02037 |
Dates | 1-JUL-2015 (Created) 20-NOV-2019 (Last updated, Version 3) |
Name | EgtD |
Scope | Bacteria; Actinobacteria |
Template | A0R5M8 (EGTD_MYCS2) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. |
Catalytic activity | RHEA:38471: L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine
EC 2.1.1.44 |
Pathway | Amino-acid biosynthesis; ergothioneine biosynthesis. |
Subunit | Monomer. |
Similarity | Belongs to the methyltransferase superfamily. EgtD family. |
Pfam | PF10017; Methyltransf_33; 1; |
TIGRFAMs | TIGR03438; egtD_ergothio; 1; |
PIRSF | PIRSF018005; UCP018005; 1; |
From: EGTD_MYCS2 (A0R5M8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 141 | 142 | S-adenosyl-L-methionine binding | D-[FMLY] | ||||||||
REGION (Optional) | 282 | 284 | L-histidine binding | E-[VI]-S | ||||||||
BINDING | 56 | 56 | L-histidine | Y | ||||||||
BINDING | 86 | 86 | S-adenosyl-L-methionine; via carbonyl oxygen | G | ||||||||
BINDING | 92 | 92 | S-adenosyl-L-methionine | K | ||||||||
BINDING | 113 | 113 | S-adenosyl-L-methionine | D | ||||||||
BINDING (Optional) | 166 | 166 | L-histidine | N | ||||||||
BINDING (Optional) | 206 | 206 | L-histidine | Y |
Size range | 311-400 amino acids |
Related rules | None |
Fusion | None |