HAMAP rule MF_02037
General rule information
[?]
Accession |
MF_02037 |
Dates |
1-JUL-2015 (Created) 1-JUN-2023 (Last updated, Version 8) |
Scope |
Bacteria; Actinomycetota |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
|
Full=Histidine N-alpha-methyltransferase;
|
|
EC 2.1.1.44;
|
AltName:
|
Full=Histidine trimethyltransferase;
|
|
Function |
Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. |
Catalytic activity |
RHEA:38471: L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine
EC 2.1.1.44
|
Pathway |
Amino-acid biosynthesis; ergothioneine biosynthesis. |
Subunit |
Monomer. |
Similarity |
Belongs to the methyltransferase superfamily. EgtD family. |
GO:0030745; Molecular function: dimethylhistidine N-methyltransferase activity.
GO:0052699; Biological process: ergothioneine biosynthetic process.
From: EGTD_MYCS2 (A0R5M8) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
BINDING
|
|
141
|
|
142
|
|
/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
|
|
|
|
D-[FMLY]
|
|
|
BINDING (Optional)
|
|
282
|
|
284
|
|
/ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595
|
|
|
|
E-[VI]-S
|
|
|
BINDING
|
|
56
|
|
56
|
|
/ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595
|
|
|
|
Y
|
|
|
BINDING
|
|
86
|
|
86
|
|
/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
|
|
|
|
G
|
|
|
BINDING
|
|
92
|
|
92
|
|
/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
|
|
|
|
K
|
|
|
BINDING
|
|
113
|
|
113
|
|
/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
|
|
|
|
D
|
|
|
BINDING (Optional)
|
|
166
|
|
166
|
|
/ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595
|
|
|
|
N
|
|
|
BINDING (Optional)
|
|
206
|
|
206
|
|
/ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595
|
|
|
|
Y
|
|
|
Additional information
[?]
Size range |
311-400 amino acids |
Related rules |
None |
Fusion |
None |