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HAMAP rule MF_02037

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General rule information [?]

Accession MF_02037
Dates 1-JUL-2015 (Created)
1-JUN-2023 (Last updated, Version 8)
Name EgtD
Bacteria; Actinomycetota
Template A0R5M8 (EGTD_MYCS2)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Histidine N-alpha-methyltransferase;
AltName: Full=Histidine trimethyltransferase;
Gene name

Comments [?]

Function Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.
Catalytic activity RHEA:38471: L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine
Pathway Amino-acid biosynthesis; ergothioneine biosynthesis.
Subunit Monomer.
Similarity Belongs to the methyltransferase superfamily. EgtD family.

Keywords [?]

Gene Ontology [?]

GO:0030745; Molecular function: dimethylhistidine N-methyltransferase activity.
GO:0052699; Biological process: ergothioneine biosynthetic process.

Cross-references [?]

Pfam PF10017; Methyltransf_33; 1;
NCBIfam TIGR03438; egtD_ergothio; 1;
PIRSF PIRSF018005; UCP018005; 1;

Features [?]

From: EGTD_MYCS2 (A0R5M8)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     141     142       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     D-[FMLY]  
BINDING (Optional)     282     284       /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595     E-[VI]-S  
BINDING     56     56       /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595     Y  
BINDING     86     86       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     G  
BINDING     92     92       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     K  
BINDING     113     113       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     D  
BINDING (Optional)     166     166       /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595     N  
BINDING (Optional)     206     206       /ligand="L-histidine" /ligand_id="ChEBI:CHEBI:57595     Y  

Additional information [?]

Size range 311-400 amino acids
Related rules None
Fusion None