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Annotation rule MF_02039
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General rule information [?]

Accession MF_02039
Dates 7-JUL-2015 (Created)
20-NOV-2019 (Last updated, Version 4)
Name FtsN_entero
Bacteria; Enterobacterales
Template P29131 (FTSN_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Cell division protein FtsN;
Gene name

Comments [?]

Function Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
Subunit Interacts with FtsA via its N-terminal cytoplasmic domain.
Subcellular location Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the septum. Localizes to the midcell via interaction with the early cell division protein FtsA and via the periplasmic SPOR domain.
Similarity Belongs to the FtsN family.

Keywords [?]

case <FTTag:disulfid>
end case

Gene Ontology [?]

GO:0090529; Biological process: cell septum assembly.
GO:0043093; Biological process: FtsZ-dependent cytokinesis.
GO:0032153; Cellular component: cell division site.
GO:0005887; Cellular component: integral component of plasma membrane.

Cross-references [?]

PROSITE PS51724; SPOR; 1; trigger=PRU01061;
Pfam PF05036; SPOR; 1;
TIGRFAMs TIGR02223; ftsN; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;
ADD_TOPO_DOMAIN Cytoplasmic; -; 1; trigger=yes;
Periplasmic; -; 1; trigger=yes;

Features [?]

From: FTSN_ECOLI (P29131)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     4     6       Mediates interaction with FtsA     [RK]-D-Y  
DISULFID     252     312           disulfid   C-x*-C  

Additional information [?]

Size range 250-360 amino acids
Related rules None
Fusion None
Comments The N-terminus is often too short.