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HAMAP rule MF_02039

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General rule information [?]

Accession MF_02039
Dates 7-JUL-2015 (Created)
1-JUN-2023 (Last updated, Version 6)
Name FtsN_entero
Scope(s) Bacteria
Template(s) P29131 (FTSN_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02039 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FTSN
Protein name RecName: Full=Cell division protein FtsN;
Gene name Name=ftsN;

Comments [?]

FUNCTIONEssential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
SUBUNITInteracts with FtsA via its N-terminal cytoplasmic domain.
SUBCELLULAR LOCATIONCell inner membrane; Single-pass type II membrane protein. Note=Localizes to the septum. Localizes to the midcell via interaction with the early cell division protein FtsA and via the periplasmic SPOR domain.
SIMILARITYBelongs to the FtsN family.

Keywords [?]

Gene Ontology [?]

GO:0090529; Biological process:cell septum assembly
GO:0043093; Biological process:FtsZ-dependent cytokinesis
GO:0032153; Cellular component:cell division site
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF05036; SPOR; 1;
NCBIfam TIGR02223; ftsN; 1;
General Transmembrane; -; 1;
ADD_TOPO_DOMAIN Cytoplasmic; -; 1;
ADD_TOPO_DOMAIN Periplasmic; -; 1;

Features [?]

From: FTSN_ECOLI (P29131)
Key From To Description Tag Condition FTGroup
REGION 4 6 /note="Mediates interaction with FtsA" [RK]-D-Y
DISULFID 252 312 disulfid C-x*-C

Additional information [?]

Size range 250-360 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The N-terminus is often too short.

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