HAMAP rule MF_02039
General rule information
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| Accession | MF_02039 |
| Dates | 7-JUL-2015 (Created)
1-JUN-2023 (Last updated, Version 6) |
| Name | FtsN_entero |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P29131 (FTSN_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_02039 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FTSN |
| Protein name | RecName: Full=Cell division protein FtsN; |
| Gene name | Name=ftsN; |
Comments
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| FUNCTION | Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. |
| SUBUNIT | Interacts with FtsA via its N-terminal cytoplasmic domain. |
| SUBCELLULAR LOCATION | Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the septum. Localizes to the midcell via interaction with the early cell division protein FtsA and via the periplasmic SPOR domain. |
| SIMILARITY | Belongs to the FtsN family. |
Keywords
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| Cell cycle | |
| Cell division | |
| Cell inner membrane | |
| Cell membrane | |
| Membrane | |
| Septation | |
| Transmembrane | |
| Transmembrane helix | |
| case <FTTag:disulfid> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| GO:0090529; Biological process:cell septum assembly |
| GO:0043093; Biological process:FtsZ-dependent cytokinesis |
| GO:0032153; Cellular component:cell division site |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| PROSITE | PS51724; SPOR; 1; |
| Pfam | PF05036; SPOR; 1; |
| NCBIfam | TIGR02223; ftsN; 1; |
| General | Transmembrane; -; 1; |
| ADD_TOPO_DOMAIN | Cytoplasmic; -; 1; |
| ADD_TOPO_DOMAIN | Periplasmic; -; 1; |
Features
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| From: FTSN_ECOLI (P29131) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 4 | 6 | /note="Mediates interaction with FtsA" | [RK]-D-Y | ||||||||
| DISULFID | 252 | 312 | disulfid | C-x*-C | ||||||||
Additional information
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| Size range | 250-360 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The N-terminus is often too short. |