HAMAP rule MF_02040

General rule information [?]

Accession	MF_02040
Dates	17-JUL-2015 (Created) 19-NOV-2022 (Last updated, Version 7)
Name	Mrp_NBP35
Scope(s)	Bacteria Archaea
Template(s)	Q8ZNN5 (APBC_SALTY); Q6LZC5 (APBC_METMP); [ Recover all ]
Triggered by	case c? <OC:Bacteria> or <OC:Archaea> HAMAP; MF_02040 (Get profile general information and statistics) end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	APBC
Protein name	RecName: Full=Iron-sulfur cluster carrier protein;

Comments [?]

FUNCTION	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the Mrp/NBP35 ATP-binding proteins family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0016887; Molecular function:ATP hydrolysis activity

GO:0051536; Molecular function:iron-sulfur cluster binding

Cross-references [?]

Features [?]

From: APBC_SALTY (Q8ZNN5)

Key

From

Description

Tag

Condition

FTGroup

BINDING

115

122

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

[GA]-K-G-G-V-G-K-[ST]

Additional information [?]

Size range	235-460 amino acids
Related rules	MF_03038 MF_03039
Fusion	Nter: None Cter: None
Comments	Profile MF_02040 includes all members of the Mrp/NBP35 family. Rule MF_02040 annotates bacterial and archaeal matches. See MF_03038 for eukaryotic NUBP1/NBP35 subfamily and MF_03039 for eukaryotic NUBP2/CFD1 subfamily. The CXXC motif is thought to be required for Fe-S cluster binding. However, the individual cysteine residues in the CXXC motif seem dispensable (see APBC_SACS2). Other members lack this characteristic CXXC motif in the C terminus. More studies will be required to determine which residues are ligands for the Fe-S cluster in bacteria and archaea.