HAMAP logo

HAMAP rule MF_02040

Send feedback

General rule information [?]

Accession MF_02040
Dates 17-JUL-2015 (Created)
19-NOV-2022 (Last updated, Version 7)
Name Mrp_NBP35
Templates Q8ZNN5 (APBC_SALTY); Q6LZC5 (APBC_METMP): [Recover all]
case <OC:Bacteria> or <OC:Archaea>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Iron-sulfur cluster carrier protein;

Comments [?]

Function Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Subunit Homodimer.
Similarity Belongs to the Mrp/NBP35 ATP-binding proteins family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0016887; Molecular function: ATP hydrolysis activity.
GO:0051536; Molecular function: iron-sulfur cluster binding.

Cross-references [?]

PROSITE PS01215; MRP; 1;
Pfam PF10609; ParA; 1;
PF01883; DUF59; 0-1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     115     122       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [GA]-K-G-G-V-G-K-[ST]  

Additional information [?]

Size range 235-460 amino acids
Related rules MF_03038 (NBP35 supersedes the current rule); MF_03039 (CFD1 supersedes the current rule)
Fusion None
Comments Profile MF_02040 includes all members of the Mrp/NBP35 family. Rule MF_02040 annotates bacterial and archaeal matches. See MF_03038 for eukaryotic NUBP1/NBP35 subfamily and MF_03039 for eukaryotic NUBP2/CFD1 subfamily. The CXXC motif is thought to be required for Fe-S cluster binding. However, the individual cysteine residues in the CXXC motif seem dispensable (see APBC_SACS2). Other members lack this characteristic CXXC motif in the C terminus. More studies will be required to determine which residues are ligands for the Fe-S cluster in bacteria and archaea.