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HAMAP rule MF_02040

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General rule information [?]

Accession MF_02040
Dates 17-JUL-2015 (Created)
19-NOV-2022 (Last updated, Version 7)
Name Mrp_NBP35
Scope(s) Bacteria
Template(s) Q8ZNN5 (APBC_SALTY); Q6LZC5 (APBC_METMP); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_02040 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier APBC
Protein name RecName: Full=Iron-sulfur cluster carrier protein;

Comments [?]

FUNCTIONBinds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
SIMILARITYBelongs to the Mrp/NBP35 ATP-binding proteins family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0016887; Molecular function:ATP hydrolysis activity
GO:0051536; Molecular function:iron-sulfur cluster binding

Cross-references [?]

PROSITE PS01215; MRP; 1;
Pfam PF10609; ParA; 1;
Pfam PF01883; DUF59; 0-1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 115 122 /ligand="ATP"

Additional information [?]

Size range 235-460 amino acids
Related rules MF_03038
Fusion Nter: None Cter: None
Comments Profile MF_02040 includes all members of the Mrp/NBP35 family. Rule MF_02040 annotates bacterial and archaeal matches. See MF_03038 for eukaryotic NUBP1/NBP35 subfamily and MF_03039 for eukaryotic NUBP2/CFD1 subfamily. The CXXC motif is thought to be required for Fe-S cluster binding. However, the individual cysteine residues in the CXXC motif seem dispensable (see APBC_SACS2). Other members lack this characteristic CXXC motif in the C terminus. More studies will be required to determine which residues are ligands for the Fe-S cluster in bacteria and archaea.

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