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Annotation rule MF_02042 |
Accession | MF_02042 |
Dates | 20-JUL-2015 (Created) 20-NOV-2019 (Last updated, Version 3) |
Name | DusB_subfam |
Scope | Bacteria; Proteobacteria |
Template | P0ABT5 (DUSB_ECOLI) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. |
Catalytic activity | RHEA:54452: a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH |
RHEA:23624: a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH | |
Cofactor | FMN |
Similarity | Belongs to the Dus family. DusB subfamily. |
PROSITE | PS01136; UPF0034; 1; |
Pfam | PF01207; Dus; 1; |
TIGRFAMs | TIGR00737; nifR3_yhdG; 1; |
PIRSF | PIRSF006621; Dus; 1; |
From: DUSB_ECOLI (P0ABT5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND (Optional) | 16 | 18 | FMN | P-M-A | ||||||||
NP_BIND (Optional) | 200 | 202 | FMN | N-G-D | ||||||||
NP_BIND (Optional) | 224 | 225 | FMN | G-R | ||||||||
ACT_SITE | 100 | 100 | Proton donor | C | ||||||||
BINDING (Optional) | 70 | 70 | FMN | Q | ||||||||
BINDING (Optional) | 139 | 139 | FMN | K |
Size range | 305-400 amino acids |
Related rules | None |
Fusion | None |