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Annotation rule MF_02044
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General rule information [?]

Accession MF_02044
Dates 3-AUG-2015 (Created)
20-NOV-2019 (Last updated, Version 5)
Name Mre11
Scope
Archaea
Templates Q8U1N9 (MRE11_PYRFU); Q8NKQ0 (MRE11_SULAC): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MRE11
Protein name
RecName: Full=DNA double-strand break repair protein Mre11;
EC 3.1.-.-;
Gene name
mre11

Comments [?]

case <OC:Halobacteria>
Function Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.
else
Function Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.
end case
Cofactor Mn(2+)
Note: Binds 2 manganese ions per subunit.
Activity regulation Nuclease activity is regulated by Rad50.
Subunit Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
Similarity Belongs to the MRE11/RAD32 family.

Keywords [?]


Gene Ontology [?]

GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0004519; Molecular function: endonuclease activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0045027; Molecular function: DNA end binding.
GO:0000403; Molecular function: Y-form DNA binding.
GO:0006302; Biological process: double-strand break repair.

Cross-references [?]

Pfam PF00149; Metallophos; 1;
PF12850; Metallophos_2; 1;

Features [?]

From: MRE11_PYRFU (Q8U1N9)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     85     85       Proton donor     H  
METAL     8     8       Manganese 1     D  
METAL     10     10       Manganese 1; via tele nitrogen     H  
METAL     49     49       Manganese 1     D  
METAL     49     49       Manganese 2     D  
METAL     84     84       Manganese 2     [NDE]  
METAL     173     173       Manganese 2; via tele nitrogen     H  
METAL (Optional)     206     206       Manganese 2; via pros nitrogen     H  
METAL (Optional)     206     206       Manganese 2     D  
METAL     208     208       Manganese 1; via tele nitrogen     H  

Additional information [?]

Size range 361-617 amino acids
Related rules None
Fusion None