HAMAP rule MF_02044
General rule information
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| Accession | MF_02044 |
| Dates | 3-AUG-2015 (Created)
19-NOV-2022 (Last updated, Version 7) |
| Name | Mre11 |
| Scope(s) |
Archaea |
| Template(s) | Q8U1N9 (MRE11_PYRFU); Q8NKQ0 (MRE11_SULAC); [ Recover all ] |
| Triggered by |
HAMAP; MF_02044 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MRE11 |
| Protein name | RecName: Full=DNA double-strand break repair protein Mre11; EC=3.1.-.-; |
| Gene name | Name=mre11; |
Comments
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| case <OC:Halobacteria> | |
| FUNCTION | Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. |
| else | |
| FUNCTION | Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. |
| end case | |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.; |
| ACTIVITY REGULATION | Nuclease activity is regulated by Rad50. |
| SUBUNIT | Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits. |
| SIMILARITY | Belongs to the MRE11/RAD32 family. |
Keywords
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Gene Ontology
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| GO:0008408; Molecular function:3'-5' exonuclease activity |
| GO:0004519; Molecular function:endonuclease activity |
| GO:0030145; Molecular function:manganese ion binding |
| GO:0045027; Molecular function:DNA end binding |
| GO:0000403; Molecular function:Y-form DNA binding |
| GO:0006302; Biological process:double-strand break repair |
Cross-references
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Features
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| From: MRE11_PYRFU (Q8U1N9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 85 | 85 | /note="Proton donor" | H | ||||||||
| BINDING | 8 | 8 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
D | ||||||||
| BINDING | 10 | 10 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
H | ||||||||
| BINDING | 49 | 49 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
D | ||||||||
| BINDING | 49 | 49 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
D | ||||||||
| BINDING | 84 | 84 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
[NDE] | ||||||||
| BINDING | 173 | 173 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
H | ||||||||
| BINDING | 206 | 206 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
H | ||||||||
| BINDING | 206 | 206 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
D | ||||||||
| BINDING | 208 | 208 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
H | ||||||||
Additional information
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| Size range | 361-617 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |