HAMAP rule MF_02044

General rule information [?]

Accession	MF_02044
Dates	3-AUG-2015 (Created) 19-NOV-2022 (Last updated, Version 7)

Name

Mre11

Scope

Archaea

Templates

Q8U1N9 (MRE11_PYRFU); Q8NKQ0 (MRE11_SULAC): [Recover all]

Triggered by

HAMAP; MF_02044 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MRE11

Protein name

RecName:		Full=DNA double-strand break repair protein Mre11;
		EC 3.1.-.-;

Gene name

mre11

Comments [?]

case <OC:Halobacteria>

Function

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

else

Function

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

end case

Cofactor	Mn(2+) Note: Binds 2 manganese ions per subunit.
Activity regulation	Nuclease activity is regulated by Rad50.
Subunit	Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
Similarity	Belongs to the MRE11/RAD32 family.

Keywords [?]

DNA damage
DNA repair
Endonuclease
Exonuclease
Hydrolase
Manganese
Metal-binding
Nuclease

Gene Ontology [?]

GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0004519; Molecular function: endonuclease activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0045027; Molecular function: DNA end binding.
GO:0000403; Molecular function: Y-form DNA binding.
GO:0006302; Biological process: double-strand break repair.

Cross-references [?]

Pfam	PF00149; Metallophos; 1;
	PF12850; Metallophos_2; 1;

Features [?]

From: MRE11_PYRFU (Q8U1N9)

Key From To Description Tag Condition FTGroup

ACT_SITE 85 85 Proton donor H

BINDING 8 8 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 D

BINDING 10 10 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 H

BINDING 49 49 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 D

BINDING 49 49 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 D

BINDING 84 84 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 [NDE]

BINDING 173 173 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 H

BINDING (Optional) 206 206 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 H

BINDING (Optional) 206 206 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 D

BINDING 208 208 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 H

Additional information [?]

Size range	361-617 amino acids
Related rules	None
Fusion	None

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