Home  |  Contact
Annotation rule MF_02045
Send feedback

General rule information [?]

Accession MF_02045
Dates 18-AUG-2015 (Created)
20-NOV-2019 (Last updated, Version 3)
Name PurE_classII
Scope
Bacteria
Archaea
Template Q73PV9 (PURE_TREDE)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PURE
Protein name
RecName: Full=Phosphoribosylaminoimidazole carboxylase;
EC 4.1.1.21;
AltName: Full=AIR carboxylase;
Short=AIRC;
Gene name
purE

Comments [?]

Function Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
Catalytic activity RHEA:10792: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2
EC 4.1.1.21
Pathway Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Similarity Belongs to the AIR carboxylase family. Class II subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004638; Molecular function: phosphoribosylaminoimidazole carboxylase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.

Cross-references [?]

Pfam PF00731; AIRC; 1;
TIGRFAMs TIGR01162; purE; 1;
PIRSF PIRSF001338; AIR_carboxylase; 1;

Features [?]

From: PURE_TREDE (Q73PV9)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     11     11       Substrate     S  
BINDING     14     14       Substrate     D  
BINDING     38     38       Substrate     S  
BINDING     41     41       Substrate     K  
BINDING     67     67       Substrate; via amide nitrogen and carbonyl oxygen     G  
BINDING     69     69       Substrate; via carbonyl oxygen     S  

Additional information [?]

Size range 150-180 amino acids
Related rules None
Fusion None
Comments See rule MF_01929 for prokaryotic class I PurEs. Class I and class II PurEs are mechanistically related but bind different substrates.