HAMAP rule MF_02045

General rule information [?]

Accession	MF_02045
Dates	18-AUG-2015 (Created) 1-JUN-2023 (Last updated, Version 5)

Name	PurE_classII

Scope

Bacteria

Archaea

Template

Q73PV9 (PURE_TREDE)

Triggered by

HAMAP; MF_02045 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PURE

Protein name

RecName:		Full=Phosphoribosylaminoimidazole carboxylase;
		EC 4.1.1.21;
AltName:		Full=AIR carboxylase;
		Short=AIRC;

Gene name

purE

Comments [?]

Function	Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
Catalytic activity	RHEA:10792: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2 EC 4.1.1.21
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Similarity	Belongs to the AIR carboxylase family. Class II subfamily.

Keywords [?]

Lyase
Purine biosynthesis

Gene Ontology [?]

GO:0004638; Molecular function: phosphoribosylaminoimidazole carboxylase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.

Cross-references [?]

Pfam	PF00731; AIRC; 1;
NCBIfam	TIGR01162; purE; 1;
PIRSF	PIRSF001338; AIR_carboxylase; 1;

Features [?]

From: PURE_TREDE (Q73PV9)

Key From To Description Tag Condition FTGroup

BINDING 11 11 /ligand="substrate S

BINDING 14 14 /ligand="substrate D

BINDING 38 38 /ligand="substrate S

BINDING 41 41 /ligand="substrate K

BINDING 67 67 /ligand="substrate G

BINDING 69 69 /ligand="substrate S

Additional information [?]

Size range	150-180 amino acids
Related rules	None
Fusion	None
Comments	See rule MF_01929 for prokaryotic class I PurEs. Class I and class II PurEs are mechanistically related but bind different substrates.

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