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HAMAP rule MF_02045

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General rule information [?]

Accession MF_02045
Dates 18-AUG-2015 (Created)
1-JUN-2023 (Last updated, Version 5)
Name PurE_classII
Scope(s) Bacteria
Template(s) Q73PV9 (PURE_TREDE); [ Recover all ]
Triggered by HAMAP; MF_02045 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PURE
Protein name RecName: Full=Phosphoribosylaminoimidazole carboxylase;
AltName: Full=AIR carboxylase;
Gene name Name=purE;

Comments [?]

FUNCTIONCatalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
CATALYTIC ACTIVITY Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2; Xref=Rhea:RHEA:10792, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:77657, ChEBI:CHEBI:137981; EC=;
PATHWAYPurine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5- phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
SIMILARITYBelongs to the AIR carboxylase family. Class II subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004638; Molecular function:phosphoribosylaminoimidazole carboxylase activity
GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

Pfam PF00731; AIRC; 1;
NCBIfam TIGR01162; purE; 1;
PIRSF PIRSF001338; AIR_carboxylase; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 11 11 /ligand="substrate" S
BINDING 14 14 /ligand="substrate" D
BINDING 38 38 /ligand="substrate" S
BINDING 41 41 /ligand="substrate" K
BINDING 67 67 /ligand="substrate" G
BINDING 69 69 /ligand="substrate" S

Additional information [?]

Size range 150-180 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments See rule MF_01929 for prokaryotic class I PurEs. Class I and class II PurEs are mechanistically related but bind different substrates.

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