HAMAP rule MF_02045
General rule information
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| Accession | MF_02045 |
| Dates | 18-AUG-2015 (Created)
1-JUN-2023 (Last updated, Version 5) |
| Name | PurE_classII |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q73PV9 (PURE_TREDE); [ Recover all ] |
| Triggered by |
HAMAP; MF_02045 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PURE |
| Protein name | RecName: Full=Phosphoribosylaminoimidazole carboxylase; EC=4.1.1.21; AltName: Full=AIR carboxylase; Short=AIRC; |
| Gene name | Name=purE; |
Comments
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| FUNCTION | Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). |
| CATALYTIC ACTIVITY | Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2; Xref=Rhea:RHEA:10792, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:77657, ChEBI:CHEBI:137981; EC=4.1.1.21; |
| PATHWAY | Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5- phospho-D-ribosyl)imidazole (carboxylase route): step 1/1. |
| SIMILARITY | Belongs to the AIR carboxylase family. Class II subfamily. |
Keywords
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Gene Ontology
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| GO:0004638; Molecular function:phosphoribosylaminoimidazole carboxylase activity |
| GO:0006189; Biological process:'de novo' IMP biosynthetic process |
Cross-references
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| Pfam | PF00731; AIRC; 1; |
| NCBIfam | TIGR01162; purE; 1; |
| PIRSF | PIRSF001338; AIR_carboxylase; 1; |
Features
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| From: PURE_TREDE (Q73PV9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 11 | 11 | /ligand="substrate" | S | ||||||||
| BINDING | 14 | 14 | /ligand="substrate" | D | ||||||||
| BINDING | 38 | 38 | /ligand="substrate" | S | ||||||||
| BINDING | 41 | 41 | /ligand="substrate" | K | ||||||||
| BINDING | 67 | 67 | /ligand="substrate" | G | ||||||||
| BINDING | 69 | 69 | /ligand="substrate" | S | ||||||||
Additional information
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| Size range | 150-180 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | See rule MF_01929 for prokaryotic class I PurEs. Class I and class II PurEs are mechanistically related but bind different substrates. |