HAMAP rule MF_02046
General rule information
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Accession | MF_02046 |
Dates | 27-AUG-2015 (Created)
25-JAN-2024 (Last updated, Version 6) |
Name | Glc6PDH_archaea |
Scope(s) |
Archaea |
Template(s) | D4GS48 (G6PD_HALVD); [ Recover all ] |
Triggered by |
HAMAP; MF_02046 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | G6PD |
Protein name | RecName: Full=NAD-dependent glucose-6-phosphate dehydrogenase; Short=Glc6PDH; EC=1.1.1.388; |
Comments
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FUNCTION | Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone. |
CATALYTIC ACTIVITY | Reaction=D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5- lactone + H(+) + NADH; Xref=Rhea:RHEA:38215, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57955, ChEBI:CHEBI:61548; EC=1.1.1.388; |
PATHWAY | Carbohydrate degradation; pentose phosphate pathway. |
SUBUNIT | Homodimer. |
SIMILARITY | Belongs to the NAD(P)-dependent epimerase/dehydratase family. |
Keywords
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Gene Ontology
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GO:0016616; Molecular function:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
GO:0051287; Molecular function:NAD binding |
GO:0009051; Biological process:pentose-phosphate shunt, oxidative branch |
Cross-references
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Pfam | PF01370; Epimerase; 1; |
Features
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From: G6PD_HALVD (D4GS48) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 152 | 152 | /note="Proton acceptor" | Y | ||||||||
BINDING | 90 | 90 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
N | ||||||||
BINDING | 115 | 115 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
S | ||||||||
BINDING | 152 | 152 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
Y | ||||||||
BINDING | 156 | 156 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
K |
Additional information
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Size range | 230-310 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |