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HAMAP rule MF_02046

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General rule information [?]

Accession MF_02046
Dates 27-AUG-2015 (Created)
25-JAN-2024 (Last updated, Version 6)
Name Glc6PDH_archaea
Scope(s) Archaea
Template(s) D4GS48 (G6PD_HALVD); [ Recover all ]
Triggered by HAMAP; MF_02046 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier G6PD
Protein name RecName: Full=NAD-dependent glucose-6-phosphate dehydrogenase;
                 Short=Glc6PDH;
                 EC=1.1.1.388;

Comments [?]

FUNCTIONCatalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
CATALYTIC ACTIVITY Reaction=D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5- lactone + H(+) + NADH; Xref=Rhea:RHEA:38215, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57955, ChEBI:CHEBI:61548; EC=1.1.1.388;
PATHWAYCarbohydrate degradation; pentose phosphate pathway.
SUBUNITHomodimer.
SIMILARITYBelongs to the NAD(P)-dependent epimerase/dehydratase family.

Keywords [?]


Gene Ontology [?]

GO:0016616; Molecular function:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287; Molecular function:NAD binding
GO:0009051; Biological process:pentose-phosphate shunt, oxidative branch

Cross-references [?]

Pfam PF01370; Epimerase; 1;

Features [?]

From: G6PD_HALVD (D4GS48)
Key From To Description Tag Condition FTGroup
ACT_SITE 152 152 /note="Proton acceptor" Y
BINDING 90 90 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
N
BINDING 115 115 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
S
BINDING 152 152 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
Y
BINDING 156 156 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
K

Additional information [?]

Size range 230-310 amino acids
Related rules None
Fusion Nter: None Cter: None



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