HAMAP rule MF_02046
General rule information
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| Accession | MF_02046 |
| Dates | 27-AUG-2015 (Created) 19-NOV-2022 (Last updated, Version 5) |
| Name | Glc6PDH_archaea |
| Scope | Archaea |
| Template | D4GS48 (G6PD_HALVD) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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Comments
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| Function | Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone. |
| Catalytic activity | RHEA:38215: D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADH
EC 1.1.1.388 |
| Pathway | Carbohydrate degradation; pentose phosphate pathway. |
| Subunit | Homodimer. |
| Similarity | Belongs to the NAD(P)-dependent epimerase/dehydratase family. |
Keywords
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Gene Ontology
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GO:0016616; Molecular function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.
GO:0051287; Molecular function: NAD binding.
GO:0051156; Biological process: glucose 6-phosphate metabolic process.
GO:0051287; Molecular function: NAD binding.
GO:0051156; Biological process: glucose 6-phosphate metabolic process.
Cross-references
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| Pfam | PF01370; Epimerase; 1; |
Features
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| From: G6PD_HALVD (D4GS48) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 152 | 152 | Proton acceptor | Y | ||||||||
| BINDING (Optional) | 90 | 90 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | N | ||||||||
| BINDING (Optional) | 115 | 115 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | S | ||||||||
| BINDING (Optional) | 152 | 152 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | Y | ||||||||
| BINDING (Optional) | 156 | 156 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | K | ||||||||
Additional information
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| Size range | 230-310 amino acids |
| Related rules | None |
| Fusion | None |