HAMAP rule MF_02046

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02046
Accession	MF_02046
Dates	27-AUG-2015 (Created) 03-SEP-2024 (Last updated, Version 8)
Name	Glc6PDH_archaea
Scope(s)	Archaea
Template(s)	D4GS48; [ Recover all ]
Triggered by	HAMAP; MF_02046 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	G6PD
Protein name	RecName: Full=NAD-dependent glucose-6-phosphate dehydrogenase; Short=Glc6PDH; EC=1.1.1.388;

Comments [?]

FUNCTION	Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
CATALYTIC ACTIVITY	Reaction=D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5- lactone + NADH + H(+); Xref=Rhea:RHEA:38215, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57955, ChEBI:CHEBI:61548; EC=1.1.1.388;
PATHWAY	Carbohydrate degradation; pentose phosphate pathway.
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the NAD(P)-dependent epimerase/dehydratase family.

Keywords [?]

Gene Ontology [?]

GO:0016616; Molecular function:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

GO:0051287; Molecular function:NAD binding

GO:0009051; Biological process:pentose-phosphate shunt, oxidative branch

Cross-references [?]

Pfam	PF01370; Epimerase; 1;

Features [?]

From: G6PD_HALVD (D4GS48)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

152

/note="Proton acceptor"

BINDING

/ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"

BINDING

115

/ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"

BINDING

152

/ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"

BINDING

156

/ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"

Additional information [?]