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Annotation rule MF_02047
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General rule information [?]

Accession MF_02047
Dates 27-AUG-2015 (Created)
20-NOV-2019 (Last updated, Version 3)
Name 6PGDH_archaea
Scope
Archaea
Template D4GST8 (6PGD_HALVD)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
6PGD
Protein name
RecName: Full=6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating;
Short=6PGDH;
EC 1.1.1.343;

Comments [?]

Function Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.
Catalytic activity RHEA:33023: 6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH
EC 1.1.1.343
Pathway Carbohydrate degradation; pentose phosphate pathway.
Subunit Homotetramer.
Similarity Belongs to the 6-phosphogluconate dehydrogenase family.

Keywords [?]


Gene Ontology [?]

GO:0016616; Molecular function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.
GO:0051287; Molecular function: NAD binding.
GO:0019521; Biological process: D-gluconate metabolic process.

Cross-references [?]

Pfam PF00393; 6PGD; 1;
PF03446; NAD_binding_2; 1;
PRINTS PR00076; 6PGDHDRGNASE; 1;
TIGRFAMs TIGR00872; gnd_rel; 1;

Features [?]

From: 6PGD_HALVD (D4GST8)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     7     12       NAD     G-L-G-R-M-G  
NP_BIND (Optional)     67     69       NAD     [VI]-P-A  
REGION (Optional)     118     120       Substrate binding     S-G-G  
REGION (Optional)     172     173       Substrate binding     H-N  
ACT_SITE     169     169       Proton acceptor     K  
ACT_SITE     176     176       Proton donor     E  
BINDING (Optional)     95     95       NAD     N  
BINDING (Optional)     95     95       Substrate     N  
BINDING (Optional)     118     118       Substrate     S  
BINDING (Optional)     177     177       Substrate     Y  
BINDING (Optional)     268     268       Substrate     R  

Additional information [?]

Size range 270-330 amino acids
Related rules None
Fusion None