HAMAP rule MF_02047
General rule information
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| Accession | MF_02047 |
| Dates | 27-AUG-2015 (Created) 1-JUN-2023 (Last updated, Version 7) |
| Name | 6PGDH_archaea |
| Scope | Archaea |
| Template | D4GST8 (6PGD_HALVD) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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Comments
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| Function | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH. |
| Catalytic activity | RHEA:33023: 6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH
EC 1.1.1.343 |
| Pathway | Carbohydrate degradation; pentose phosphate pathway. |
| Subunit | Homotetramer. |
| Similarity | Belongs to the 6-phosphogluconate dehydrogenase family. |
Keywords
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Gene Ontology
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GO:0016616; Molecular function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.
GO:0051287; Molecular function: NAD binding.
GO:0019521; Biological process: D-gluconate metabolic process.
GO:0051287; Molecular function: NAD binding.
GO:0019521; Biological process: D-gluconate metabolic process.
Cross-references
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| Pfam | PF00393; 6PGD; 1; |
| PF03446; NAD_binding_2; 1; | |
| PRINTS | PR00076; 6PGDHDRGNASE; 1; |
| NCBIfam | TIGR00872; gnd_rel; 1; |
Features
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| From: 6PGD_HALVD (D4GST8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING (Optional) | 7 | 12 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | G-L-G-R-M-G | ||||||||
| BINDING (Optional) | 67 | 69 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [VI]-P-A | ||||||||
| BINDING (Optional) | 118 | 120 | /ligand="substrate | S-G-G | ||||||||
| BINDING (Optional) | 172 | 173 | /ligand="substrate | H-N | ||||||||
| ACT_SITE | 169 | 169 | Proton acceptor | K | ||||||||
| ACT_SITE | 176 | 176 | Proton donor | E | ||||||||
| BINDING (Optional) | 95 | 95 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | N | ||||||||
| BINDING (Optional) | 95 | 95 | /ligand="substrate | N | ||||||||
| BINDING (Optional) | 118 | 118 | /ligand="substrate | S | ||||||||
| BINDING (Optional) | 177 | 177 | /ligand="substrate | Y | ||||||||
| BINDING (Optional) | 268 | 268 | /ligand="substrate | R | ||||||||
Additional information
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| Size range | 270-330 amino acids |
| Related rules | None |
| Fusion | None |