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HAMAP rule MF_02047

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General rule information [?]

Accession MF_02047
Dates 27-AUG-2015 (Created)
25-JAN-2024 (Last updated, Version 8)
Name 6PGDH_archaea
Scope(s) Archaea
Template(s) D4GST8 (6PGD_HALVD); [ Recover all ]
Triggered by HAMAP; MF_02047 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier 6PGD
Protein name RecName: Full=6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating;

Comments [?]

FUNCTIONCatalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.
CATALYTIC ACTIVITY Reaction=6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH; Xref=Rhea:RHEA:33023, ChEBI:CHEBI:16526, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58121, ChEBI:CHEBI:58759; EC=;
PATHWAYCarbohydrate degradation; pentose phosphate pathway.
SIMILARITYBelongs to the 6-phosphogluconate dehydrogenase family.

Keywords [?]

Gene Ontology [?]

GO:0016616; Molecular function:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287; Molecular function:NAD binding
GO:0009051; Biological process:pentose-phosphate shunt, oxidative branch

Cross-references [?]

Pfam PF00393; 6PGD; 1;
Pfam PF03446; NAD_binding_2; 1;
NCBIfam TIGR00872; gnd_rel; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 7 12 /ligand="NAD(+)"
BINDING 67 69 /ligand="NAD(+)"
BINDING 118 120 /ligand="substrate" S-G-G
BINDING 172 173 /ligand="substrate" H-N
ACT_SITE 169 169 /note="Proton acceptor" K
ACT_SITE 176 176 /note="Proton donor" E
BINDING 95 95 /ligand="NAD(+)"
BINDING 95 95 /ligand="substrate" N
BINDING 118 118 /ligand="substrate" S
BINDING 177 177 /ligand="substrate" Y
BINDING 268 268 /ligand="substrate" R

Additional information [?]

Size range 270-330 amino acids
Related rules None
Fusion Nter: None Cter: None

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