HAMAP rule MF_02048
General rule information
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| Accession | MF_02048 |
| Dates | 14-OCT-2015 (Created)
1-JUN-2023 (Last updated, Version 11) |
| Name | Deacylase_DTD3 |
| Scope(s) |
Bacteria Cyanobacteriota |
| Template(s) | P73335 (DTD3_SYNY3); [ Recover all ] |
| Triggered by |
HAMAP; MF_02048 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DTD3 |
| Protein name | RecName: Full=D-aminoacyl-tRNA deacylase; EC=3.1.1.96; |
| Gene name | Name=dtd3; |
Comments
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| FUNCTION | Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr). |
| CATALYTIC ACTIVITY | Reaction=a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+); Xref=Rhea:RHEA:13953, Rhea:RHEA-COMP:10123, Rhea:RHEA-COMP:10124, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59871, ChEBI:CHEBI:78442, ChEBI:CHEBI:79333; EC=3.1.1.96; |
| CATALYTIC ACTIVITY | Reaction=D-tyrosyl-tRNA(Tyr) + H2O = D-tyrosine + tRNA(Tyr); Xref=Rhea:RHEA:25347, Rhea:RHEA-COMP:9707, Rhea:RHEA-COMP:9872, ChEBI:CHEBI:15377, ChEBI:CHEBI:58570, ChEBI:CHEBI:78442, ChEBI:CHEBI:78723; |
| COFACTOR | Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit |
| SIMILARITY | Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. DTD3 subfamily. |
Keywords
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Gene Ontology
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| GO:0051499; Molecular function:D-aminoacyl-tRNA deacylase activity |
| GO:0019478; Biological process:D-amino acid catabolic process |
Cross-references
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| PROSITE | PS01137; TATD_1; 1; |
| PROSITE | PS01090; TATD_2; 1; |
| PROSITE | PS01091; TATD_3; 1; |
| Pfam | PF01026; TatD_DNase; 1; |
| NCBIfam | TIGR00010; TIGR00010; 1; |
| PIRSF | PIRSF005902; DNase_TatD; 1; |
Features
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| From: DTD3_SYNY3 (P73335) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 7 | 7 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1" |
H | ||||||||
| BINDING | 9 | 9 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1" |
H | ||||||||
| BINDING | 94 | 94 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1" |
E | ||||||||
| BINDING | 94 | 94 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2" |
E | ||||||||
| BINDING | 129 | 129 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2" |
H | ||||||||
| BINDING | 156 | 156 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2" |
H | ||||||||
| BINDING | 206 | 206 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1" |
D | ||||||||
Additional information
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| Size range | 240-310 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |