HAMAP rule MF_02052
General rule information
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| Accession | MF_02052 |
| Dates | 7-JAN-2016 (Created)
4-JUN-2021 (Last updated, Version 6) |
| Name | LsrF |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P76143 (LSRF_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_02052 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LSRF |
| Protein name | RecName: Full=3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase; EC=2.3.1.245; |
| Gene name | Name=lsrF; |
Comments
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| FUNCTION | Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA. |
| CATALYTIC ACTIVITY | Reaction=acetyl-CoA + dihydroxyacetone phosphate = 3-hydroxy-2,4- dioxopentyl phosphate + CoA; Xref=Rhea:RHEA:44736, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57642, ChEBI:CHEBI:84359; EC=2.3.1.245; |
| SUBUNIT | Homodecamer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the DeoC/FbaB aldolase family. |
Keywords
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Gene Ontology
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| GO:0016747; Molecular function:acyltransferase activity, transferring groups other than amino-acyl groups |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01791; DeoC; 1; |
| PIRSF | PIRSF038992; Aldolase_Ia; 1; |
Features
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| From: LSRF_ECOLI (P76143) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 203 | 203 | /note="Schiff-base intermediate with substrate" | K | ||||||||
Additional information
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| Size range | 290-310 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |