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HAMAP rule MF_02052

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General rule information [?]

Accession MF_02052
Dates 7-JAN-2016 (Created)
4-JUN-2021 (Last updated, Version 6)
Name LsrF
Scope(s) Bacteria
Template(s) P76143 (LSRF_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02052 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LSRF
Protein name RecName: Full=3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase;
Gene name Name=lsrF;

Comments [?]

FUNCTIONInvolved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.
CATALYTIC ACTIVITY Reaction=acetyl-CoA + dihydroxyacetone phosphate = 3-hydroxy-2,4- dioxopentyl phosphate + CoA; Xref=Rhea:RHEA:44736, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57642, ChEBI:CHEBI:84359; EC=;
SIMILARITYBelongs to the DeoC/FbaB aldolase family.

Keywords [?]

Gene Ontology [?]

GO:0016747; Molecular function:acyltransferase activity, transferring groups other than amino-acyl groups
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01791; DeoC; 1;
PIRSF PIRSF038992; Aldolase_Ia; 1;

Features [?]

From: LSRF_ECOLI (P76143)
Key From To Description Tag Condition FTGroup
ACT_SITE 203 203 /note="Schiff-base intermediate with substrate" K

Additional information [?]

Size range 290-310 amino acids
Related rules None
Fusion Nter: None Cter: None

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