Home  |  Contact
Annotation rule MF_02053
Send feedback

General rule information [?]

Accession MF_02053
Dates 8-JAN-2016 (Created)
5-MAY-2020 (Last updated, Version 5)
Name LsrK
Bacteria; Enterobacterales
Templates Q8ZKQ6 (LSRK_SALTY); P77432 (LSRK_ECOLI): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Autoinducer-2 kinase;
Short=AI-2 kinase;
Gene name

Comments [?]

Function Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
Catalytic activity RHEA:15377: (S)-4,5-dihydroxypentane-2,3-dione + ATP = (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)
Subcellular location Cytoplasm.
Similarity Belongs to the FGGY kinase family.

Keywords [?]

Gene Ontology [?]

GO:0071518; Molecular function: autoinducer-2 kinase activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF02782; FGGY_C; 1;
PF00370; FGGY_N; 1;
PIRSF PIRSF000538; GlpK; 1;

Additional information [?]

Size range 515-545 amino acids
Related rules None
Fusion None