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Annotation rule MF_02053 |
Accession | MF_02053 |
Dates | 8-JAN-2016 (Created) 5-MAY-2020 (Last updated, Version 5) |
Name | LsrK |
Scope | Bacteria; Enterobacterales |
Templates | Q8ZKQ6 (LSRK_SALTY); P77432 (LSRK_ECOLI): [Recover all] |
Triggered by |
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Protein name |
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Gene name |
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Function | Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. |
Catalytic activity | RHEA:15377: (S)-4,5-dihydroxypentane-2,3-dione + ATP = (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)
EC 2.7.1.189 |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the FGGY kinase family. |
Pfam | PF02782; FGGY_C; 1; |
PF00370; FGGY_N; 1; | |
PIRSF | PIRSF000538; GlpK; 1; |
Size range | 515-545 amino acids |
Related rules | None |
Fusion | None |