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| Annotation rule MF_02053 |
General rule information
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| Accession | MF_02053 |
| Dates | 8-JAN-2016 (Created) 5-MAY-2020 (Last updated, Version 5) |
| Name | LsrK |
| Scope | Bacteria; Enterobacterales |
| Templates | Q8ZKQ6 (LSRK_SALTY); P77432 (LSRK_ECOLI): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. |
| Catalytic activity | RHEA:15377: (S)-4,5-dihydroxypentane-2,3-dione + ATP = (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)
EC 2.7.1.189 |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the FGGY kinase family. |
Keywords
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Gene Ontology
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GO:0071518; Molecular function: autoinducer-2 kinase activity.
GO:0005737; Cellular component: cytoplasm.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF02782; FGGY_C; 1; |
| PF00370; FGGY_N; 1; | |
| PIRSF | PIRSF000538; GlpK; 1; |
Additional information
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| Size range | 515-545 amino acids |
| Related rules | None |
| Fusion | None |