HAMAP rule MF_02053

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02053
Accession	MF_02053
Dates	8-JAN-2016 (Created) 5-MAY-2020 (Last updated, Version 5)
Name	LsrK
Scope(s)	Bacteria Enterobacterales
Template(s)	Q8ZKQ6 (LSRK_SALTY); P77432 (LSRK_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_02053 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LSRK
Protein name	RecName: Full=Autoinducer-2 kinase; Short=AI-2 kinase; EC=2.7.1.189;
Gene name	Name=lsrK;

Comments [?]

FUNCTION	Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
CATALYTIC ACTIVITY	Reaction=(S)-4,5-dihydroxypentane-2,3-dione + ATP = (2S)-2-hydroxy-3,4- dioxopentyl phosphate + ADP + H(+); Xref=Rhea:RHEA:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29484, ChEBI:CHEBI:30616, ChEBI:CHEBI:71677, ChEBI:CHEBI:456216; EC=2.7.1.189;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the FGGY kinase family.

Keywords [?]

Gene Ontology [?]

GO:0071518; Molecular function:autoinducer-2 kinase activity

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]