HAMAP logo

HAMAP rule MF_02053

Send feedback

General rule information [?]

Accession MF_02053
Dates 8-JAN-2016 (Created)
5-MAY-2020 (Last updated, Version 5)
Name LsrK
Scope(s) Bacteria
Template(s) Q8ZKQ6 (LSRK_SALTY); P77432 (LSRK_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02053 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LSRK
Protein name RecName: Full=Autoinducer-2 kinase;
                 Short=AI-2 kinase;
Gene name Name=lsrK;

Comments [?]

FUNCTIONCatalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
CATALYTIC ACTIVITY Reaction=(S)-4,5-dihydroxypentane-2,3-dione + ATP = (2S)-2-hydroxy-3,4- dioxopentyl phosphate + ADP + H(+); Xref=Rhea:RHEA:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29484, ChEBI:CHEBI:30616, ChEBI:CHEBI:71677, ChEBI:CHEBI:456216; EC=;
SIMILARITYBelongs to the FGGY kinase family.

Keywords [?]

Gene Ontology [?]

GO:0071518; Molecular function:autoinducer-2 kinase activity
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF02782; FGGY_C; 1;
Pfam PF00370; FGGY_N; 1;
PIRSF PIRSF000538; GlpK; 1;

Features [?]

Additional information [?]

Size range 515-545 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)