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| Annotation rule MF_02056 |
General rule information
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| Accession | MF_02056 |
| Dates | 15-FEB-2016 (Created) 20-NOV-2019 (Last updated, Version 3) |
| Name | MetZ |
| Scope | Bacteria |
| Templates | P55218 (METZ_PSEAE); P9WGB5 (METZ_MYCTU): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide. |
| Catalytic activity | RHEA:27826: hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate |
| Cofactor | pyridoxal 5'-phosphate |
| Pathway | Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-succinyl-L-homoserine: step 1/1. |
| Subunit | Homotetramer. |
| Similarity | Belongs to the trans-sulfuration enzymes family. MetZ subfamily. |
Keywords
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Gene Ontology
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GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0071266; Biological process: 'de novo' L-methionine biosynthetic process.
GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0071266; Biological process: 'de novo' L-methionine biosynthetic process.
Cross-references
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| PROSITE | PS00868; CYS_MET_METAB_PP; 1; |
| Pfam | PF01053; Cys_Met_Meta_PP; 1; |
| TIGRFAMs | TIGR01325; O_suc_HS_sulf; 1; |
| PIRSF | PIRSF001434; CGS; 1; |
Features
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| From: METZ_MYCTU (P9WGB5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 219 | 219 | N6-(pyridoxal phosphate)lysine | K | ||||||||
Additional information
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| Size range | 380-460 amino acids |
| Related rules | None |
| Fusion | None |