HAMAP rule MF_02056
General rule information
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| Accession | MF_02056 |
| Dates | 15-FEB-2016 (Created)
1-JUN-2023 (Last updated, Version 4) |
| Name | MetZ |
| Scope(s) |
Bacteria |
| Template(s) | P55218 (METZ_PSEAE); P9WGB5 (METZ_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_02056 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | METZ |
| Protein name | RecName: Full=O-succinylhomoserine sulfhydrylase; Short=OSH sulfhydrylase; Short=OSHS sulfhydrylase; EC=2.5.1.-; |
| Gene name | Name=metZ; |
Comments
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| FUNCTION | Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. |
| CATALYTIC ACTIVITY | Reaction=hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate; Xref=Rhea:RHEA:27826, ChEBI:CHEBI:29919, ChEBI:CHEBI:30031, ChEBI:CHEBI:57661, ChEBI:CHEBI:58199; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| PATHWAY | Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-succinyl-L-homoserine: step 1/1. |
| SUBUNIT | Homotetramer. |
| SIMILARITY | Belongs to the trans-sulfuration enzymes family. MetZ subfamily. |
Keywords
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Gene Ontology
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| GO:0030170; Molecular function:pyridoxal phosphate binding |
| GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups |
| GO:0071266; Biological process:'de novo' L-methionine biosynthetic process |
Cross-references
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| PROSITE | PS00868; CYS_MET_METAB_PP; 1; |
| Pfam | PF01053; Cys_Met_Meta_PP; 1; |
| NCBIfam | TIGR01325; O_suc_HS_sulf; 1; |
| PIRSF | PIRSF001434; CGS; 1; |
Features
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| From: METZ_MYCTU (P9WGB5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 219 | 219 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 380-460 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |