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HAMAP rule MF_02056

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General rule information [?]

Accession MF_02056
Dates 15-FEB-2016 (Created)
1-JUN-2023 (Last updated, Version 4)
Name MetZ
Scope(s) Bacteria
Template(s) P55218 (METZ_PSEAE); P9WGB5 (METZ_MYCTU); [ Recover all ]
Triggered by HAMAP; MF_02056 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier METZ
Protein name RecName: Full=O-succinylhomoserine sulfhydrylase;
                 Short=OSH sulfhydrylase;
                 Short=OSHS sulfhydrylase;
Gene name Name=metZ;

Comments [?]

FUNCTIONCatalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
CATALYTIC ACTIVITY Reaction=hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate; Xref=Rhea:RHEA:27826, ChEBI:CHEBI:29919, ChEBI:CHEBI:30031, ChEBI:CHEBI:57661, ChEBI:CHEBI:58199;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAYAmino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-succinyl-L-homoserine: step 1/1.
SIMILARITYBelongs to the trans-sulfuration enzymes family. MetZ subfamily.

Keywords [?]

Gene Ontology [?]

GO:0030170; Molecular function:pyridoxal phosphate binding
GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0071266; Biological process:'de novo' L-methionine biosynthetic process

Cross-references [?]

Pfam PF01053; Cys_Met_Meta_PP; 1;
NCBIfam TIGR01325; O_suc_HS_sulf; 1;
PIRSF PIRSF001434; CGS; 1;

Features [?]

Key From To Description Tag Condition FTGroup
MOD_RES 219 219 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 380-460 amino acids
Related rules None
Fusion Nter: None Cter: None

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