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Annotation rule MF_02056
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General rule information [?]

Accession MF_02056
Dates 15-FEB-2016 (Created)
20-NOV-2019 (Last updated, Version 3)
Name MetZ
Scope
Bacteria
Templates P55218 (METZ_PSEAE); P9WGB5 (METZ_MYCTU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
METZ
Protein name
RecName: Full=O-succinylhomoserine sulfhydrylase;
Short=OSH sulfhydrylase;
Short=OSHS sulfhydrylase;
EC 2.5.1.-;
Gene name
metZ

Comments [?]

Function Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
Catalytic activity RHEA:27826: hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate
Cofactor pyridoxal 5'-phosphate
Pathway Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-succinyl-L-homoserine: step 1/1.
Subunit Homotetramer.
Similarity Belongs to the trans-sulfuration enzymes family. MetZ subfamily.

Keywords [?]


Gene Ontology [?]

GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0071266; Biological process: 'de novo' L-methionine biosynthetic process.

Cross-references [?]

PROSITE PS00868; CYS_MET_METAB_PP; 1;
Pfam PF01053; Cys_Met_Meta_PP; 1;
TIGRFAMs TIGR01325; O_suc_HS_sulf; 1;
PIRSF PIRSF001434; CGS; 1;

Features [?]

From: METZ_MYCTU (P9WGB5)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     219     219       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 380-460 amino acids
Related rules None
Fusion None