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HAMAP rule MF_02057

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General rule information [?]

Accession MF_02057
Dates 8-MAR-2016 (Created)
13-OCT-2023 (Last updated, Version 8)
Name tRNA_methyltr_CmoM
Scope(s) Bacteria
Template(s) P36566 (CMOM_ECOLI); Q8XDG3 (CMOM_ECO57); [ Recover all ]
Triggered by HAMAP; MF_02057 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CMOM
Protein name RecName: Full=tRNA 5-carboxymethoxyuridine methyltransferase;
AltName: Full=cmo5U methyltransferase;
Gene name Name=cmoM;

Comments [?]

FUNCTIONCatalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs.
CATALYTIC ACTIVITY Reaction=5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54080, Rhea:RHEA-COMP:13383, Rhea:RHEA- COMP:13781, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:136879, ChEBI:CHEBI:138053;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.

Keywords [?]

Gene Ontology [?]

GO:0097697; Molecular function:tRNA (5-carboxymethoxyuridine(34)-5-O)-methyltransferase activity
GO:0006400; Biological process:tRNA modification

Cross-references [?]

Pfam PF13847; Methyltransf_31; 0-1;
Pfam PF08241; Methyltransf_11; 0-1;

Features [?]

From: CMOM_ECO57 (Q8XDG3)
Key From To Description Tag Condition FTGroup
BINDING 52 53 /ligand="S-adenosyl-L-methionine"
BINDING 102 103 /ligand="S-adenosyl-L-methionine"
BINDING 26 26 /ligand="S-adenosyl-L-methionine"
BINDING 73 73 /ligand="S-adenosyl-L-methionine"
BINDING 119 119 /ligand="S-adenosyl-L-methionine"

Additional information [?]

Size range 240-320 amino acids
Related rules None
Fusion Nter: None Cter: None

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