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Annotation rule MF_02059 |
General rule information
[?]
Accession |
MF_02059 |
Dates |
11-MAR-2016 (Created) 27-JAN-2020 (Last updated, Version 3) |
Scope |
Bacteria; Coriobacteriales
Bacteria; Firmicutes
Bacteria; Proteobacteria |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Choline trimethylamine-lyase activating enzyme;
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EC 1.97.1.-;
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AltName:
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Full=Choline utilization protein D;
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AltName:
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Full=GRE activase CutD;
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AltName:
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Full=Glycyl-radical enzyme activating enzyme CutD;
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Short=GRE activating enzyme CutD;
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Function |
Catalyzes activation of the choline trimethylamine-lyase CutC under anaerobic conditions by generation of an organic free radical on a glycine residue, via an homolytic cleavage of S-adenosyl-L-methionine (SAM). |
Catalytic activity |
RHEA:61976: glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]
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case <FTGroup:1> and <FTGroup:2>
Cofactor |
[4Fe-4S] cluster Note: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine; |
else
end case
Pathway |
Amine and polyamine metabolism; choline degradation. |
Similarity |
Belongs to the organic radical-activating enzymes family. |
GO:0016491; Molecular function: oxidoreductase activity.
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0042426; Biological process: choline catabolic process.
From: CUTD_DESAG (Q30W71) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION
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37
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39
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S-adenosyl-L-methionine binding
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|
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W-C-[SA]
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REGION
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188
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190
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S-adenosyl-L-methionine binding
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D-[VLIM]-K
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METAL
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31
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31
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Iron-sulfur 1 (4Fe-4S-S-AdoMet)
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|
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C
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1
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METAL
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35
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35
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Iron-sulfur 1 (4Fe-4S-S-AdoMet)
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|
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C
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1
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METAL
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38
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38
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Iron-sulfur 1 (4Fe-4S-S-AdoMet)
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C
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1
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METAL
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57
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57
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Iron-sulfur 2 (4Fe-4S)
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|
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C
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2
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METAL
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60
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60
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Iron-sulfur 2 (4Fe-4S)
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C
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2
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METAL
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63
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63
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Iron-sulfur 2 (4Fe-4S)
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|
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C
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2
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METAL
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99
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99
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Iron-sulfur 2 (4Fe-4S)
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C
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2
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BINDING
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139
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139
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S-adenosyl-L-methionine; via carbonyl oxygen
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G
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BINDING
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264
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264
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S-adenosyl-L-methionine; via carbonyl oxygen and amide nitrogen
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H
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Additional information
[?]
Size range |
300-360 amino acids |
Related rules |
None |
Fusion |
None |