HAMAP rule MF_02060
General rule information
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Accession | MF_02060 |
Dates | 16-MAR-2016 (Created) 19-NOV-2022 (Last updated, Version 6) |
Name | tRNA_methyltr_TrmH |
Scope | Bacteria |
Templates | Q5SM16 (TRMH_THET8); P0AGJ2 (TRMH_ECOLI); Q72GI1 (TRMH_THET2); O67577 (TRMH_AQUAE): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA. |
Catalytic activity | RHEA:20077: guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.34 |
Similarity | Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. |
Keywords
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Gene Ontology
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GO:0009020; Molecular function: tRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0000049; Molecular function: tRNA binding.
GO:0002938; Biological process: tRNA guanine ribose methylation.
GO:0000049; Molecular function: tRNA binding.
GO:0002938; Biological process: tRNA guanine ribose methylation.
Cross-references
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Features
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From: TRMH_THET8 (Q5SM16) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 122 | 126 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | G-x-E-[KR]-W | ||||||||
BINDING (Optional) | 99 | 99 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [TS] | ||||||||
BINDING (Optional) | 142 | 142 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [ILV] | ||||||||
BINDING (Optional) | 151 | 151 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | L |
Additional information
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Size range | 187-267 amino acids |
Related rules | None |
Fusion | None |