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HAMAP rule MF_02060

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General rule information [?]

Accession MF_02060
Dates 16-MAR-2016 (Created)
13-OCT-2023 (Last updated, Version 7)
Name tRNA_methyltr_TrmH
Scope(s) Bacteria
Template(s) Q5SM16 (TRMH_THET8); P0AGJ2 (TRMH_ECOLI); Q72GI1 (TRMH_THET2); O67577 (TRMH_AQUAE); [ Recover all ]
Triggered by HAMAP; MF_02060 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRMH
Protein name RecName: Full=tRNA (guanosine(18)-2'-O)-methyltransferase;
AltName: Full=tRNA [Gm18] methyltransferase;
Gene name Name=trmH;

Comments [?]

FUNCTIONCatalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
CATALYTIC ACTIVITY Reaction=guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O- methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:20077, Rhea:RHEA-COMP:10190, Rhea:RHEA-COMP:10192, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74445; EC=;
SIMILARITYBelongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

Keywords [?]

Gene Ontology [?]

GO:0141100; Molecular function:tRNA (guanine(18)-2'-O)-methyltransferase activity
GO:0000049; Molecular function:tRNA binding
GO:0002938; Biological process:tRNA guanine ribose methylation

Cross-references [?]

Pfam PF12105; SpoU_methylas_C; 1;
Pfam PF00588; SpoU_methylase; 1;

Features [?]

From: TRMH_THET8 (Q5SM16)
Key From To Description Tag Condition FTGroup
BINDING 122 126 /ligand="S-adenosyl-L-methionine"
BINDING 99 99 /ligand="S-adenosyl-L-methionine"
BINDING 142 142 /ligand="S-adenosyl-L-methionine"
BINDING 151 151 /ligand="S-adenosyl-L-methionine"

Additional information [?]

Size range 187-267 amino acids
Related rules None
Fusion Nter: None Cter: None

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