HAMAP rule MF_02060
General rule information
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| Accession | MF_02060 |
| Dates | 16-MAR-2016 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Name | tRNA_methyltr_TrmH |
| Scope(s) |
Bacteria |
| Template(s) | Q5SM16 (TRMH_THET8); P0AGJ2 (TRMH_ECOLI); Q72GI1 (TRMH_THET2); O67577 (TRMH_AQUAE); [ Recover all ] |
| Triggered by |
HAMAP; MF_02060 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TRMH |
| Protein name | RecName: Full=tRNA (guanosine(18)-2'-O)-methyltransferase; EC=2.1.1.34; AltName: Full=tRNA [Gm18] methyltransferase; |
| Gene name | Name=trmH; |
Comments
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| FUNCTION | Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA. |
| CATALYTIC ACTIVITY | Reaction=guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O- methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:20077, Rhea:RHEA-COMP:10190, Rhea:RHEA-COMP:10192, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74445; EC=2.1.1.34; |
| SIMILARITY | Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. |
Keywords
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Gene Ontology
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| GO:0009020; Molecular function:tRNA (guanosine-2'-O-)-methyltransferase activity |
| GO:0000049; Molecular function:tRNA binding |
| GO:0002938; Biological process:tRNA guanine ribose methylation |
Cross-references
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Features
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| From: TRMH_THET8 (Q5SM16) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 122 | 126 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G-x-E-[KR]-W | ||||||||
| BINDING | 99 | 99 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[TS] | ||||||||
| BINDING | 142 | 142 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[ILV] | ||||||||
| BINDING | 151 | 151 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
L | ||||||||
Additional information
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| Size range | 187-267 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |