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Annotation rule MF_02060
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General rule information [?]

Accession MF_02060
Dates 16-MAR-2016 (Created)
20-NOV-2019 (Last updated, Version 3)
Name tRNA_methyltr_TrmH
Scope
Bacteria
Templates Q5SM16 (TRMH_THET8); P0AGJ2 (TRMH_ECOLI); Q72GI1 (TRMH_THET2); O67577 (TRMH_AQUAE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TRMH
Protein name
RecName: Full=tRNA (guanosine(18)-2'-O)-methyltransferase;
EC 2.1.1.34;
AltName: Full=tRNA [Gm18] methyltransferase;
Gene name
trmH

Comments [?]

Function Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
Catalytic activity RHEA:20077: guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.34
Similarity Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

Keywords [?]

Methyltransferase
RNA-binding
S-adenosyl-L-methionine
Transferase
tRNA processing
tRNA-binding

Gene Ontology [?]

GO:0009020; Molecular function: tRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0000049; Molecular function: tRNA binding.
GO:0002938; Biological process: tRNA guanine ribose methylation.

Cross-references [?]

Pfam PF12105; SpoU_methylas_C; 1;
PF00588; SpoU_methylase; 1;

Features [?]

From: TRMH_THET8 (Q5SM16)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     122     126       S-adenosyl-L-methionine binding     G-x-E-[KR]-W  
BINDING (Optional)     99     99       S-adenosyl-L-methionine     [TS]  
BINDING (Optional)     142     142       S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen     [ILV]  
BINDING (Optional)     151     151       S-adenosyl-L-methionine; via amide nitrogen     L  

Additional information [?]

Size range 187-267 amino acids
Related rules None
Fusion None


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