HAMAP rule MF_02060

General rule information [?]

Accession	MF_02060
Dates	16-MAR-2016 (Created) 19-NOV-2022 (Last updated, Version 6)

Name	tRNA_methyltr_TrmH

Scope

Bacteria

Templates

Q5SM16 (TRMH_THET8); P0AGJ2 (TRMH_ECOLI); Q72GI1 (TRMH_THET2); O67577 (TRMH_AQUAE): [Recover all]

Triggered by

HAMAP; MF_02060 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TRMH

Protein name

RecName:		Full=tRNA (guanosine(18)-2'-O)-methyltransferase;
		EC 2.1.1.34;
AltName:		Full=tRNA [Gm18] methyltransferase;

Gene name

trmH

Comments [?]

Function	Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
Catalytic activity	RHEA:20077: guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine EC 2.1.1.34
Similarity	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

Keywords [?]

Methyltransferase
RNA-binding
S-adenosyl-L-methionine
Transferase
tRNA processing
tRNA-binding

Gene Ontology [?]

GO:0009020; Molecular function: tRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0000049; Molecular function: tRNA binding.
GO:0002938; Biological process: tRNA guanine ribose methylation.

Cross-references [?]

Pfam	PF12105; SpoU_methylas_C; 1;
	PF00588; SpoU_methylase; 1;

Features [?]

From: TRMH_THET8 (Q5SM16)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 122 126 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 G-x-E-[KR]-W

BINDING (Optional) 99 99 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [TS]

BINDING (Optional) 142 142 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [ILV]

BINDING (Optional) 151 151 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 L

Additional information [?]

Size range	187-267 amino acids
Related rules	None
Fusion	None

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