HAMAP rule MF_02061
General rule information
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| Accession | MF_02061 |
| Dates | 30-MAR-2016 (Created)
4-APR-2020 (Last updated, Version 6) |
| Name | Thiored_glutath_peroxid |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P06610 (BTUE_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_02061 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | BTUE |
| Protein name | RecName: Full=Thioredoxin/glutathione peroxidase BtuE; EC=1.11.1.24; EC=1.11.1.9; |
| Gene name | Name=btuE; |
Comments
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| FUNCTION | Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent. |
| CATALYTIC ACTIVITY | Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; |
| CATALYTIC ACTIVITY | Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]- disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; |
| SIMILARITY | Belongs to the glutathione peroxidase family. BtuE subfamily. |
Keywords
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Gene Ontology
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| GO:0004602; Molecular function:glutathione peroxidase activity |
| GO:0051920; Molecular function:peroxiredoxin activity |
Cross-references
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| PROSITE | PS00460; GLUTATHIONE_PEROXID_1; 1; |
| PROSITE | PS00763; GLUTATHIONE_PEROXID_2; 1; |
| PROSITE | PS51355; GLUTATHIONE_PEROXID_3; 1; |
| Pfam | PF00255; GSHPx; 1; |
| PRINTS | PR01011; GLUTPROXDASE; 1; |
| PIRSF | PIRSF000303; Glutathion_perox; 1; |
Features
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| From: BTUE_ECOLI (P06610) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 37 | 37 | C | |||||||||
Additional information
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| Size range | 180-200 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |