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Annotation rule MF_02067 |
Accession | MF_02067 |
Dates | 30-JUN-2016 (Created) 20-NOV-2019 (Last updated, Version 4) |
Name | FBP_aldolase_phosphatase |
Scope | Bacteria
Archaea |
Templates | F9VMT6 (FBPAP_SULTO); B1YAL1 (FBPAP_PYRNV); Q2RG86 (FBPAP_MOOTA); Q72K02 (FBPAP_THET2); A0RV30 (FBPAP_CENSY); A8A9E4 (FBPAP_IGNH4); A4YIZ5 (FBPAP_METS5); D9PUH5 (FBPAP_METTM); Q8NKR9 (FBPAP_THEKO): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). |
Catalytic activity | RHEA:11064: beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate
EC 3.1.3.11 |
RHEA:14729: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
EC 4.1.2.13 |
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Cofactor | Mg(2+) |
Pathway | Carbohydrate biosynthesis; gluconeogenesis. |
Subunit | Homooctamer; dimer of tetramers. |
Domain | Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities. |
Similarity | Belongs to the FBP aldolase/phosphatase family. |
Pfam | PF01950; FBPase_3; 1; |
PIRSF | PIRSF015647; FBPtase_archl; 1; |
From: FBPAP_SULTO (F9VMT6) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION (Optional) | 103 | 104 | FBP binding | G-N | ||||||||
REGION (Optional) | 241 | 242 | FBP binding; shared with dimeric partner | Q-[HSK] | ||||||||
ACT_SITE | 11 | 11 | Proton acceptor; for FBP phosphatase activity | D | ||||||||
ACT_SITE | 228 | 228 | Proton donor/acceptor; for FBP aldolase activity | Y | ||||||||
ACT_SITE | 231 | 231 | Schiff-base intermediate with DHAP; for FBP aldolase activity | K | ||||||||
METAL | 11 | 11 | Magnesium 1 | D | ||||||||
METAL | 18 | 18 | Magnesium 1; via pros nitrogen | H | ||||||||
METAL | 52 | 52 | Magnesium 1 | D | ||||||||
METAL | 52 | 52 | Magnesium 2 | D | ||||||||
METAL | 53 | 53 | Magnesium 2 | D | ||||||||
METAL | 94 | 94 | Magnesium 1 | Q | ||||||||
METAL | 131 | 131 | Magnesium 2 | D | ||||||||
METAL | 231 | 231 | Magnesium 3; via carbonyl oxygen | K | ||||||||
METAL | 232 | 232 | Magnesium 3 | D | ||||||||
METAL | 232 | 232 | Magnesium 4 | D | ||||||||
METAL | 233 | 233 | Magnesium 2 | D | ||||||||
METAL | 233 | 233 | Magnesium 3 | D | ||||||||
BINDING (Optional) | 18 | 18 | FBP; via tele nitrogen | H | ||||||||
BINDING (Optional) | 90 | 90 | FBP | Y | ||||||||
BINDING (Optional) | 132 | 132 | FBP/DHAP | K | ||||||||
BINDING (Optional) | 265 | 265 | FBP/DHAP; via amide nitrogen | R | ||||||||
BINDING (Optional) | 286 | 286 | FBP/DHAP | D | ||||||||
BINDING (Optional) | 347 | 347 | FBP | Y |
Size range | 360-410 amino acids |
Related rules | None |
Fusion | None |