HAMAP rule MF_02068
General rule information
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Accession | MF_02068 |
Dates | 12-JUL-2016 (Created)
19-NOV-2022 (Last updated, Version 6) |
Name | TarI |
Scope(s) |
Bacteria |
Template(s) | Q8DPI2 (TARI_STRR6); Q8RKI9 (TARI_BACSH); Q2G1C0 (TARI1_STAA8); Q2G2C4 (TARI2_STAA8); [ Recover all ] |
Triggered by |
HAMAP; MF_02068 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | TARI |
Protein name | RecName: Full=Ribitol-5-phosphate cytidylyltransferase; EC=2.7.7.40; |
case <OC:Bacilli> | |
Gene name | Name=tarI; |
end case |
Comments
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FUNCTION | Catalyzes the transfer of the cytidylyl group of CTP to D- ribitol 5-phosphate. |
CATALYTIC ACTIVITY | Reaction=CTP + D-ribitol 5-phosphate + H(+) = CDP-L-ribitol + diphosphate; Xref=Rhea:RHEA:12456, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:57608, ChEBI:CHEBI:57695; EC=2.7.7.40; |
case <OC:Bacilli> | |
PATHWAY | Cell wall biogenesis; poly(ribitol phosphate) teichoic acid biosynthesis. |
end case | |
SIMILARITY | Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily. |
Keywords
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Nucleotidyltransferase | |
Transferase | |
case <OC:Bacilli> | |
Cell wall biogenesis/degradation | |
Teichoic acid biosynthesis | |
end case |
Gene Ontology
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GO:0047349; Molecular function:D-ribitol-5-phosphate cytidylyltransferase activity | |
case <OCellular component:Bacilli> | |
GO:1902012; Biological process:poly(ribitol phosphate) teichoic acid biosynthetic process | |
end case |
Cross-references
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Features
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From: TARI_STRR6 (Q8DPI2) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 7 | 10 | /ligand="CTP" /ligand_id="ChEBI:CHEBI:37563" |
[LF]-A-G-G | ||||||||
BINDING | 82 | 88 | /ligand="CTP" /ligand_id="ChEBI:CHEBI:37563" |
G-x(3)-[NQ]-x-[ST] | ||||||||
BINDING | 113 | 113 | /ligand="CTP" /ligand_id="ChEBI:CHEBI:37563" |
S | ||||||||
SITE | 14 | 14 | /note="Transition state stabilizer" | R | ||||||||
SITE | 22 | 22 | /note="Transition state stabilizer" | K | ||||||||
SITE | 161 | 161 | /note="Positions ribitol 5-phosphate for the nucleophilic attack" | R | ||||||||
SITE | 218 | 218 | /note="Positions ribitol 5-phosphate for the nucleophilic attack" | K |
Additional information
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Size range | 220-260 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |