HAMAP rule MF_02068
General rule information
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| Accession | MF_02068 |
| Dates | 12-JUL-2016 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Name | TarI |
| Scope(s) |
Bacteria |
| Template(s) | Q8DPI2 (TARI_STRR6); Q8RKI9 (TARI_BACSH); Q2G1C0 (TARI1_STAA8); Q2G2C4 (TARI2_STAA8); [ Recover all ] |
| Triggered by |
HAMAP; MF_02068 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TARI |
| Protein name | RecName: Full=Ribitol-5-phosphate cytidylyltransferase; EC=2.7.7.40; |
| case <OC:Bacilli> | |
| Gene name | Name=tarI; |
| end case | |
Comments
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| FUNCTION | Catalyzes the transfer of the cytidylyl group of CTP to D- ribitol 5-phosphate. |
| CATALYTIC ACTIVITY | Reaction=CTP + D-ribitol 5-phosphate + H(+) = CDP-L-ribitol + diphosphate; Xref=Rhea:RHEA:12456, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:57608, ChEBI:CHEBI:57695; EC=2.7.7.40; |
| case <OC:Bacilli> | |
| PATHWAY | Cell wall biogenesis; poly(ribitol phosphate) teichoic acid biosynthesis. |
| end case | |
| SIMILARITY | Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily. |
Keywords
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| Nucleotidyltransferase | |
| Transferase | |
| case <OC:Bacilli> | |
| Cell wall biogenesis/degradation | |
| Teichoic acid biosynthesis | |
| end case | |
Gene Ontology
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| GO:0047349; Molecular function:D-ribitol-5-phosphate cytidylyltransferase activity | |
| case <OCellular component:Bacilli> | |
| GO:1902012; Biological process:poly(ribitol phosphate) teichoic acid biosynthetic process | |
| end case | |
Cross-references
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Features
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| From: TARI_STRR6 (Q8DPI2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 7 | 10 | /ligand="CTP" /ligand_id="ChEBI:CHEBI:37563" |
[LF]-A-G-G | ||||||||
| BINDING | 82 | 88 | /ligand="CTP" /ligand_id="ChEBI:CHEBI:37563" |
G-x(3)-[NQ]-x-[ST] | ||||||||
| BINDING | 113 | 113 | /ligand="CTP" /ligand_id="ChEBI:CHEBI:37563" |
S | ||||||||
| SITE | 14 | 14 | /note="Transition state stabilizer" | R | ||||||||
| SITE | 22 | 22 | /note="Transition state stabilizer" | K | ||||||||
| SITE | 161 | 161 | /note="Positions ribitol 5-phosphate for the nucleophilic attack" | R | ||||||||
| SITE | 218 | 218 | /note="Positions ribitol 5-phosphate for the nucleophilic attack" | K | ||||||||
Additional information
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| Size range | 220-260 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |