HAMAP rule MF_02069
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_02069 |
| Accession | MF_02069 |
| Dates | 14-JUL-2016 (Created)
12-JUN-2025 (Last updated, Version 10) |
| Name | TarJ |
| Scope(s) |
Bacteria |
| Template(s) | Q8DPI3; Q8RKJ0; Q2G1B9; Q2G1C4; [ Recover all ] |
| Triggered by |
HAMAP; MF_02069 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TARJ |
| Protein name | RecName: Full=Ribulose-5-phosphate reductase; Short=Ribulose-5-P reductase; EC=1.1.1.405; AltName: Full=Ribitol-5-phosphate dehydrogenase; |
| case <OC:Bacilli> | |
| Gene name | Name=tarJ; |
| end case | |
Comments
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| FUNCTION | Catalyzes the NADPH dependent reduction of D-ribulose 5- phosphate to D-ribitol 5-phosphate. |
| CATALYTIC ACTIVITY | Reaction=D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + NADPH + H(+); Xref=Rhea:RHEA:19921, ChEBI:CHEBI:15378, ChEBI:CHEBI:57695, ChEBI:CHEBI:57783, ChEBI:CHEBI:58121, ChEBI:CHEBI:58349; EC=1.1.1.405; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; |
| case <OC:Bacilli> | |
| PATHWAY | Cell wall biogenesis; poly(ribitol phosphate) teichoic acid biosynthesis. |
| end case | |
| SIMILARITY | Belongs to the zinc-containing alcohol dehydrogenase family. |
Keywords
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| Metal-binding | |
| NADP | |
| Oxidoreductase | |
| Zinc | |
| case <OC:Bacilli> | |
| Cell wall biogenesis/degradation | |
| Teichoic acid biosynthesis | |
| end case | |
Gene Ontology
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| GO:0050256; Molecular function:ribitol-5-phosphate 2-dehydrogenase [NAD(P)+] activity | |
| GO:0008270; Molecular function:zinc ion binding | |
| case <OCellular component:Bacilli> | |
| GO:1902012; Biological process:poly(ribitol phosphate) teichoic acid biosynthetic process | |
| end case | |
Cross-references
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Features
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| From: TARJ_STRR6 (Q8DPI3) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 45 | 45 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
C | 1 | |||||||
| BINDING | 71 | 71 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 72 | 72 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
E | 1 | |||||||
| BINDING | 151 | 151 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
E | 1 | |||||||
Additional information
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| Size range | 330-370 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |