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HAMAP rule MF_02069

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General rule information [?]

Accession MF_02069
Dates 14-JUL-2016 (Created)
19-NOV-2022 (Last updated, Version 6)
Name TarJ
Scope
Bacteria
Templates Q8DPI3 (TARJ_STRR6); Q8RKJ0 (TARJ_BACSH); Q2G1B9 (TARJ1_STAA8); Q2G1C4 (TARJ2_STAA8): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TARJ
Protein name
RecName: Full=Ribulose-5-phosphate reductase;
Short=Ribulose-5-P reductase;
EC 1.1.1.405;
AltName: Full=Ribitol-5-phosphate dehydrogenase;
case <OC:Bacilli>
Gene name
tarJ
end case

Comments [?]

Function Catalyzes the NADPH dependent reduction of D-ribulose 5-phosphate to D-ribitol 5-phosphate.
Catalytic activity RHEA:19921: D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + H(+) + NADPH
EC 1.1.1.405
Cofactor Zn(2+)
case <OC:Bacilli>
Pathway Cell wall biogenesis; poly(ribitol phosphate) teichoic acid biosynthesis.
end case
Similarity Belongs to the zinc-containing alcohol dehydrogenase family.

Keywords [?]

Metal-binding
NADP
Oxidoreductase
Zinc
case <OC:Bacilli>
Cell wall biogenesis/degradation
Teichoic acid biosynthesis
end case

Gene Ontology [?]

GO:0050256; Molecular function: ribitol-5-phosphate 2-dehydrogenase activity.
GO:0008270; Molecular function: zinc ion binding.
case <OC:Bacilli>
GO:1902012; Biological process: poly(ribitol phosphate) teichoic acid biosynthetic process.
end case

Cross-references [?]

Pfam PF08240; ADH_N; 1;
PF00107; ADH_zinc_N; 1;
PROSITE PS00059; ADH_ZINC; 1;

Features [?]

From: TARJ_STRR6 (Q8DPI3)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     45     45       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     C   1
BINDING     71     71       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     72     72       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     E   1
BINDING     151     151       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     E   1

Additional information [?]

Size range 330-370 amino acids
Related rules None
Fusion None


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