HAMAP rule MF_02074
General rule information
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| Accession | MF_02074 |
| Dates | 30-AUG-2016 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Name | Bact_renalase |
| Scope(s) |
Bacteria Pseudomonadales |
| Template(s) | Q48MT7 (RNLS_PSE14); Q888A4 (RNLS_PSESM); [ Recover all ] |
| Triggered by |
HAMAP; MF_02074 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RNLS |
| Protein name | RecName: Full=Renalase; EC=1.6.3.5; |
Comments
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| FUNCTION | Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P)+. May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers. |
| CATALYTIC ACTIVITY | Reaction=1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+); Xref=Rhea:RHEA:40395, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:88138; EC=1.6.3.5; |
| CATALYTIC ACTIVITY | Reaction=1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:40399, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58349, ChEBI:CHEBI:88137; EC=1.6.3.5; |
| CATALYTIC ACTIVITY | Reaction=1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:48000, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58349, ChEBI:CHEBI:88139; EC=1.6.3.5; |
| CATALYTIC ACTIVITY | Reaction=1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+); Xref=Rhea:RHEA:47996, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:88140; EC=1.6.3.5; |
| COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
| SIMILARITY | Belongs to the bacterial renalase family. |
Keywords
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Gene Ontology
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| GO:0050660; Molecular function:flavin adenine dinucleotide binding |
| GO:0050661; Molecular function:NADP binding |
| GO:0051287; Molecular function:NAD binding |
| GO:0050664; Molecular function:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor |
Cross-references
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| Pfam | PF01593; Amino_oxidase; 1; |
Features
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| From: RNLS_PSE14 (Q48MT7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 32 | 33 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
[DE]-K | ||||||||
| BINDING | 56 | 57 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
Q-Y | ||||||||
| BINDING | 57 | 61 | /ligand="substrate" | Y-F-T-x-R | ||||||||
| BINDING | 96 | 98 | /ligand="substrate" | S-P-D | ||||||||
| BINDING | 13 | 13 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
[AS] | ||||||||
| BINDING | 40 | 40 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
R | ||||||||
| BINDING | 128 | 128 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
[IV] | ||||||||
| BINDING | 185 | 185 | /ligand="substrate" | T | ||||||||
| BINDING | 302 | 302 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
D | ||||||||
| BINDING | 308 | 308 | /ligand="substrate" | R | ||||||||
| BINDING | 309 | 309 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
V | ||||||||
Additional information
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| Size range | 320-350 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |