HAMAP rule MF_02074
General rule information
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| Accession | MF_02074 |
| Dates | 30-AUG-2016 (Created) 19-NOV-2022 (Last updated, Version 6) |
| Name | Bact_renalase |
| Scope | Bacteria; Pseudomonadales |
| Templates | Q48MT7 (RNLS_PSE14); Q888A4 (RNLS_PSESM): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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Comments
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| Function | Catalyzes the oxidation of the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P)+. May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers. |
| Catalytic activity | RHEA:40395: 1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)
EC 1.6.3.5 |
| RHEA:40399: 1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)
EC 1.6.3.5 |
|
| RHEA:48000: 1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)
EC 1.6.3.5 |
|
| RHEA:47996: 1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)
EC 1.6.3.5 |
|
| Cofactor | FAD |
| Similarity | Belongs to the bacterial renalase family. |
Keywords
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Gene Ontology
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GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0050661; Molecular function: NADP binding.
GO:0051287; Molecular function: NAD binding.
GO:0050664; Molecular function: oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor.
GO:0050661; Molecular function: NADP binding.
GO:0051287; Molecular function: NAD binding.
GO:0050664; Molecular function: oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor.
Cross-references
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| Pfam | PF01593; Amino_oxidase; 1; |
Features
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| From: RNLS_PSE14 (Q48MT7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING (Optional) | 32 | 33 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692 | [DE]-K | ||||||||
| BINDING (Optional) | 56 | 57 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692 | Q-Y | ||||||||
| BINDING (Optional) | 57 | 61 | /ligand="substrate | Y-F-T-x-R | ||||||||
| BINDING (Optional) | 96 | 98 | /ligand="substrate | S-P-D | ||||||||
| BINDING (Optional) | 13 | 13 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692 | [AS] | ||||||||
| BINDING (Optional) | 40 | 40 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692 | R | ||||||||
| BINDING (Optional) | 128 | 128 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692 | [IV] | ||||||||
| BINDING (Optional) | 185 | 185 | /ligand="substrate | T | ||||||||
| BINDING (Optional) | 302 | 302 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692 | D | ||||||||
| BINDING (Optional) | 308 | 308 | /ligand="substrate | R | ||||||||
| BINDING (Optional) | 309 | 309 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692 | V | ||||||||
Additional information
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| Size range | 320-350 amino acids |
| Related rules | None |
| Fusion | None |