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HAMAP rule MF_02074

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General rule information [?]

Accession MF_02074
Dates 30-AUG-2016 (Created)
19-NOV-2022 (Last updated, Version 6)
Name Bact_renalase
Scope(s) Bacteria
Template(s) Q48MT7 (RNLS_PSE14); Q888A4 (RNLS_PSESM); [ Recover all ]
Triggered by HAMAP; MF_02074 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RNLS
Protein name RecName: Full=Renalase;

Comments [?]

FUNCTIONCatalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P)+. May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers.
CATALYTIC ACTIVITY Reaction=1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+); Xref=Rhea:RHEA:40395, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:88138; EC=;
CATALYTIC ACTIVITY Reaction=1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:40399, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58349, ChEBI:CHEBI:88137; EC=;
CATALYTIC ACTIVITY Reaction=1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:48000, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58349, ChEBI:CHEBI:88139; EC=;
CATALYTIC ACTIVITY Reaction=1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+); Xref=Rhea:RHEA:47996, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:88140; EC=;
SIMILARITYBelongs to the bacterial renalase family.

Keywords [?]

Gene Ontology [?]

GO:0050660; Molecular function:flavin adenine dinucleotide binding
GO:0050661; Molecular function:NADP binding
GO:0051287; Molecular function:NAD binding
GO:0050664; Molecular function:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

Cross-references [?]

Pfam PF01593; Amino_oxidase; 1;

Features [?]

From: RNLS_PSE14 (Q48MT7)
Key From To Description Tag Condition FTGroup
BINDING 32 33 /ligand="FAD"
BINDING 56 57 /ligand="FAD"
BINDING 57 61 /ligand="substrate" Y-F-T-x-R
BINDING 96 98 /ligand="substrate" S-P-D
BINDING 13 13 /ligand="FAD"
BINDING 40 40 /ligand="FAD"
BINDING 128 128 /ligand="FAD"
BINDING 185 185 /ligand="substrate" T
BINDING 302 302 /ligand="FAD"
BINDING 308 308 /ligand="substrate" R
BINDING 309 309 /ligand="FAD"

Additional information [?]

Size range 320-350 amino acids
Related rules None
Fusion Nter: None Cter: None

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