HAMAP rule MF_02074
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_02074 |
| Accession | MF_02074 |
| Dates | 30-AUG-2016 (Created)
03-SEP-2024 (Last updated, Version 8) |
| Name | Bact_renalase |
| Scope(s) |
Bacteria Pseudomonadales |
| Template(s) | Q48MT7; Q888A4; [ Recover all ] |
| Triggered by |
HAMAP; MF_02074 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | RNLS |
| Protein name | RecName: Full=Renalase; EC=1.6.3.5; |
Comments
[?]
| FUNCTION | Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P)+. May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers. |
| CATALYTIC ACTIVITY | Reaction=1,2-dihydro-beta-NAD + O2 + H(+) = H2O2 + NAD(+); Xref=Rhea:RHEA:40395, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:88138; EC=1.6.3.5; |
| CATALYTIC ACTIVITY | Reaction=1,2-dihydro-beta-NADP + O2 + H(+) = H2O2 + NADP(+); Xref=Rhea:RHEA:40399, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58349, ChEBI:CHEBI:88137; EC=1.6.3.5; |
| CATALYTIC ACTIVITY | Reaction=1,6-dihydro-beta-NADP + O2 + H(+) = H2O2 + NADP(+); Xref=Rhea:RHEA:48000, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58349, ChEBI:CHEBI:88139; EC=1.6.3.5; |
| CATALYTIC ACTIVITY | Reaction=1,6-dihydro-beta-NAD + O2 + H(+) = H2O2 + NAD(+); Xref=Rhea:RHEA:47996, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:88140; EC=1.6.3.5; |
| COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
| SIMILARITY | Belongs to the bacterial renalase family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0050660; Molecular function:flavin adenine dinucleotide binding |
| GO:0050661; Molecular function:NADP binding |
| GO:0051287; Molecular function:NAD binding |
| GO:0050664; Molecular function:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor |
Cross-references
[?]
| Pfam | PF01593; Amino_oxidase; 1; |
Features
[?]
| From: RNLS_PSE14 (Q48MT7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 32 | 33 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
[DE]-K | ||||||||
| BINDING | 56 | 57 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
Q-Y | ||||||||
| BINDING | 57 | 61 | /ligand="substrate" | Y-F-T-x-R | ||||||||
| BINDING | 96 | 98 | /ligand="substrate" | S-P-D | ||||||||
| BINDING | 13 | 13 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
[AS] | ||||||||
| BINDING | 40 | 40 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
R | ||||||||
| BINDING | 128 | 128 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
[IV] | ||||||||
| BINDING | 185 | 185 | /ligand="substrate" | T | ||||||||
| BINDING | 302 | 302 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
D | ||||||||
| BINDING | 308 | 308 | /ligand="substrate" | R | ||||||||
| BINDING | 309 | 309 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
V | ||||||||
Additional information
[?]
| Size range | 320-350 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |