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HAMAP rule MF_02074

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General rule information [?]

Accession MF_02074
Dates 30-AUG-2016 (Created)
19-NOV-2022 (Last updated, Version 6)
Name Bact_renalase
Bacteria; Pseudomonadales
Templates Q48MT7 (RNLS_PSE14); Q888A4 (RNLS_PSESM): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Renalase;

Comments [?]

Function Catalyzes the oxidation of the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P)+. May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers.
Catalytic activity RHEA:40395: 1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)
RHEA:40399: 1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)
RHEA:48000: 1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)
RHEA:47996: 1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)
Cofactor FAD
Similarity Belongs to the bacterial renalase family.

Keywords [?]

Gene Ontology [?]

GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0050661; Molecular function: NADP binding.
GO:0051287; Molecular function: NAD binding.
GO:0050664; Molecular function: oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor.

Cross-references [?]

Pfam PF01593; Amino_oxidase; 1;

Features [?]

From: RNLS_PSE14 (Q48MT7)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     32     33       /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692     [DE]-K  
BINDING (Optional)     56     57       /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692     Q-Y  
BINDING (Optional)     57     61       /ligand="substrate     Y-F-T-x-R  
BINDING (Optional)     96     98       /ligand="substrate     S-P-D  
BINDING (Optional)     13     13       /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692     [AS]  
BINDING (Optional)     40     40       /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692     R  
BINDING (Optional)     128     128       /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692     [IV]  
BINDING (Optional)     185     185       /ligand="substrate     T  
BINDING (Optional)     302     302       /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692     D  
BINDING (Optional)     308     308       /ligand="substrate     R  
BINDING (Optional)     309     309       /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692     V  

Additional information [?]

Size range 320-350 amino acids
Related rules None
Fusion None