HAMAP logo

HAMAP rule MF_02076

Send feedback

General rule information [?]

Accession MF_02076
Dates 10-NOV-2016 (Created)
1-JUN-2023 (Last updated, Version 5)
Name Glu_tRNA_synth_type2
Scope(s) Archaea
Template(s) P04805 (SYE_ECOLI); O25360 (SYE2_HELPY); P27000 (SYE_THET8); Q8DLI5 (SYE_THEVB); [ Recover all ]
Triggered by HAMAP; MF_02076 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SYE
Protein name RecName: Full=Glutamate--tRNA ligase;
AltName: Full=Glutamyl-tRNA synthetase;
Gene name Name=gltX;

Comments [?]

FUNCTIONCatalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
CATALYTIC ACTIVITY Reaction=ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L- glutamyl-tRNA(Glu); Xref=Rhea:RHEA:23540, Rhea:RHEA-COMP:9663, Rhea:RHEA-COMP:9680, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78520, ChEBI:CHEBI:456215; EC=;
SIMILARITYBelongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004818; Molecular function:glutamate-tRNA ligase activity
GO:0006424; Biological process:glutamyl-tRNA aminoacylation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00749; tRNA-synt_1c; 1;
Pfam PF03950; tRNA-synt_1c_C; 1;
NCBIfam TIGR00463; gltX_arch; 1;

Features [?]

From: SYE_METJA (Q58772)
Key From To Description Tag Condition FTGroup
MOTIF 98 108 /note="'HIGH' region" P-[SNE]-P-x(4)-[HTS]-[LIVM]-G-x

Additional information [?]

Size range 530-640 amino acids
Related rules MF_01428
Fusion Nter: None Cter: None
Comments This signature is specific for archaeal and eukaryotic cytoplasmic glutamate--tRNA ligases. See MF_00022 for bacterial and eukaryotic mitochondrial glutamate--tRNA ligases.

View rule in raw text format (no links)