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Annotation rule MF_02076
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General rule information [?]

Accession MF_02076
Dates 10-NOV-2016 (Created)
20-NOV-2019 (Last updated, Version 4)
Name Glu_tRNA_synth_type2
Scope
Archaea
Templates P04805 (SYE_ECOLI); O25360 (SYE2_HELPY); P27000 (SYE_THET8); Q8DLI5 (SYE_THEEB): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SYE
Protein name
RecName: Full=Glutamate--tRNA ligase;
EC 6.1.1.17;
AltName: Full=Glutamyl-tRNA synthetase;
Short=GluRS;
Gene name
gltX

Comments [?]

Function Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Catalytic activity RHEA:23540: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)
EC 6.1.1.17
Subcellular location Cytoplasm.
Similarity Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.

Keywords [?]

Aminoacyl-tRNA synthetase
ATP-binding
Cytoplasm
Ligase
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004818; Molecular function: glutamate-tRNA ligase activity.
GO:0006424; Biological process: glutamyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00178; AA_TRNA_LIGASE_I; 1;
Pfam PF00749; tRNA-synt_1c; 1;
PF03950; tRNA-synt_1c_C; 1;
PRINTS PR00987; TRNASYNTHGLU; 1;
TIGRFAMs TIGR00463; gltX_arch; 1;

Features [?]

From: SYE_METJA (Q58772)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     98     108       'HIGH' region     P-[SNE]-P-x(4)-[HTS]-[LIVM]-G-x  

Additional information [?]

Size range 530-640 amino acids
Related rules MF_01428 (GLUQ)
Fusion None
Comments This signature is specific for archaeal and eukaryotic cytoplasmic glutamate--tRNA ligases. See MF_00022 for bacterial and eukaryotic mitochondrial glutamate--tRNA ligases.


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