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Annotation rule MF_02080 |
General rule information
[?]
Accession |
MF_02080 |
Dates |
1-DEC-2016 (Created) 20-NOV-2019 (Last updated, Version 5) |
Scope |
Bacteria; Proteobacteria |
Propagated annotation
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Identifier, protein and gene names
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case not <OC:Neisseria>
Protein name |
RecName:
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Full=Peptidoglycan D,D-transpeptidase FtsI;
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EC 3.4.16.4;
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AltName:
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Full=Penicillin-binding protein 3;
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Short=PBP-3;
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else case <OC:Neisseria>
Protein name |
RecName:
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Full=Probable peptidoglycan D,D-transpeptidase PenA;
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EC 3.4.16.4;
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AltName:
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Full=Penicillin-binding protein 2;
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Short=PBP-2;
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end case
Function |
Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. |
Catalytic activity |
Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=3.4.16.4; |
Pathway |
Cell wall biogenesis; peptidoglycan biosynthesis. |
case <Feature:Transmembrane==1>
Subcellular location |
Cell inner membrane; Single-pass membrane protein. |
end case
Similarity |
Belongs to the transpeptidase family. FtsI subfamily. |
GO:0009002; Molecular function: serine-type D-Ala-D-Ala carboxypeptidase activity.
GO:0043093; Biological process: FtsZ-dependent cytokinesis.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005887; Cellular component: integral component of plasma membrane.
General |
Transmembrane; -; 1; trigger=yes; |
From: FTSI_ECOLI (P0AD68) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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307
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307
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Acyl-ester intermediate
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S
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Additional information
[?]
Size range |
520-690 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Second copy in Pseudomonas aeruginosa (penicillin-binding protein 3 homolog), which has probably the same catalytic activity. Does not match FTSI_CAUVN, which seems divergent. |