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HAMAP rule MF_02080

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General rule information [?]

Accession MF_02080
Dates 1-DEC-2016 (Created)
26-JAN-2023 (Last updated, Version 8)
Name FtsI_transpept
Scope(s) Bacteria
Template(s) P0AD68 (FTSI_ECOLI); P08149 (PBP2_NEIGO); [ Recover all ]
Triggered by HAMAP; MF_02080 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case not <OC:Neisseria>
Identifier FTSI
Protein name RecName: Full=Peptidoglycan D,D-transpeptidase FtsI;
AltName: Full=Penicillin-binding protein 3;
Gene name Name=ftsI;
else case <OC:Neisseria>
Identifier PBP2
Protein name RecName: Full=Probable peptidoglycan D,D-transpeptidase PenA;
AltName: Full=Penicillin-binding protein 2;
Gene name Name=penA;
end case

Comments [?]

FUNCTIONCatalyzes cross-linking of the peptidoglycan cell wall at the division septum.
CATALYTIC ACTIVITY Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=;
PATHWAYCell wall biogenesis; peptidoglycan biosynthesis.
case <Feature:Transmembrane==1>
SUBCELLULAR LOCATIONCell inner membrane; Single-pass membrane protein.
end case
SIMILARITYBelongs to the transpeptidase family. FtsI subfamily.

Keywords [?]

Gene Ontology [?]

GO:0009002; Molecular function:serine-type D-Ala-D-Ala carboxypeptidase activity
GO:0043093; Biological process:FtsZ-dependent cytokinesis
GO:0009252; Biological process:peptidoglycan biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF03717; PBP_dimer; 1;
Pfam PF00905; Transpeptidase; 1;
General Transmembrane; -; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 307 307 /note="Acyl-ester intermediate" S

Additional information [?]

Size range 520-690 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Second copy in Pseudomonas aeruginosa (penicillin-binding protein 3 homolog), which has probably the same catalytic activity. Does not match FTSI_CAUVN, which seems divergent.

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