HAMAP rule MF_02080
General rule information
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Accession | MF_02080 |
Dates | 1-DEC-2016 (Created)
26-JAN-2023 (Last updated, Version 8) |
Name | FtsI_transpept |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P0AD68 (FTSI_ECOLI); P08149 (PBP2_NEIGO); [ Recover all ] |
Triggered by |
HAMAP; MF_02080 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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case not <OC:Neisseria> | |
Identifier | FTSI |
Protein name | RecName: Full=Peptidoglycan D,D-transpeptidase FtsI; EC=3.4.16.4; AltName: Full=Penicillin-binding protein 3; Short=PBP-3; |
Gene name | Name=ftsI; |
else case <OC:Neisseria> | |
Identifier | PBP2 |
Protein name | RecName: Full=Probable peptidoglycan D,D-transpeptidase PenA; EC=3.4.16.4; AltName: Full=Penicillin-binding protein 2; Short=PBP-2; |
Gene name | Name=penA; |
end case |
Comments
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FUNCTION | Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. |
CATALYTIC ACTIVITY | Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=3.4.16.4; |
PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
case <Feature:Transmembrane==1> | |
SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the transpeptidase family. FtsI subfamily. |
Keywords
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Gene Ontology
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GO:0009002; Molecular function:serine-type D-Ala-D-Ala carboxypeptidase activity |
GO:0043093; Biological process:FtsZ-dependent cytokinesis |
GO:0009252; Biological process:peptidoglycan biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF03717; PBP_dimer; 1; |
Pfam | PF00905; Transpeptidase; 1; |
General | Transmembrane; -; 1; |
Features
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From: FTSI_ECOLI (P0AD68) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 307 | 307 | /note="Acyl-ester intermediate" | S |
Additional information
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Size range | 520-690 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Second copy in Pseudomonas aeruginosa (penicillin-binding protein 3 homolog), which has probably the same catalytic activity. Does not match FTSI_CAUVN, which seems divergent. |