HAMAP rule MF_02080
General rule information
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Accession | MF_02080 |
Dates | 1-DEC-2016 (Created) 26-JAN-2023 (Last updated, Version 8) |
Name | FtsI_transpept |
Scope | Bacteria; Pseudomonadota |
Templates | P0AD68 (FTSI_ECOLI); P08149 (PBP2_NEIGO): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case not <OC:Neisseria>
Identifier |
|
Protein name |
|
Gene name |
|
else case <OC:Neisseria>
Identifier |
|
Protein name |
|
Gene name |
|
end case
Comments
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Function | Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. |
Catalytic activity | Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=3.4.16.4; |
Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. |
case <Feature:Transmembrane==1>
Subcellular location | Cell inner membrane; Single-pass membrane protein. |
end case
Similarity | Belongs to the transpeptidase family. FtsI subfamily. |
Keywords
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Carboxypeptidase
Cell cycle
Cell division
Cell inner membrane
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Hydrolase
Membrane
Peptidoglycan synthesis
Protease
Septation
Transmembrane
Transmembrane helix
Cell cycle
Cell division
Cell inner membrane
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Hydrolase
Membrane
Peptidoglycan synthesis
Protease
Septation
Transmembrane
Transmembrane helix
Gene Ontology
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GO:0009002; Molecular function: serine-type D-Ala-D-Ala carboxypeptidase activity.
GO:0043093; Biological process: FtsZ-dependent cytokinesis.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0043093; Biological process: FtsZ-dependent cytokinesis.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Computed features
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General | Transmembrane; -; 1; trigger=yes; |
Features
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From: FTSI_ECOLI (P0AD68) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 307 | 307 | Acyl-ester intermediate | S |
Additional information
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Size range | 520-690 amino acids |
Related rules | None |
Fusion | None |
Comments | Second copy in Pseudomonas aeruginosa (penicillin-binding protein 3 homolog), which has probably the same catalytic activity. Does not match FTSI_CAUVN, which seems divergent. |