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HAMAP rule MF_02080

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General rule information [?]

Accession MF_02080
Dates 1-DEC-2016 (Created)
26-JAN-2023 (Last updated, Version 8)
Name FtsI_transpept
Scope
Bacteria; Pseudomonadota
Templates P0AD68 (FTSI_ECOLI); P08149 (PBP2_NEIGO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case not <OC:Neisseria>
Identifier
FTSI
Protein name
RecName: Full=Peptidoglycan D,D-transpeptidase FtsI;
EC 3.4.16.4;
AltName: Full=Penicillin-binding protein 3;
Short=PBP-3;
Gene name
ftsI
else case <OC:Neisseria>
Identifier
PBP2
Protein name
RecName: Full=Probable peptidoglycan D,D-transpeptidase PenA;
EC 3.4.16.4;
AltName: Full=Penicillin-binding protein 2;
Short=PBP-2;
Gene name
penA
end case

Comments [?]

Function Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
Catalytic activity Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=3.4.16.4;
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
case <Feature:Transmembrane==1>
Subcellular location Cell inner membrane; Single-pass membrane protein.
end case
Similarity Belongs to the transpeptidase family. FtsI subfamily.

Keywords [?]

Carboxypeptidase
Cell cycle
Cell division
Cell inner membrane
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Hydrolase
Membrane
Peptidoglycan synthesis
Protease
Septation
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0009002; Molecular function: serine-type D-Ala-D-Ala carboxypeptidase activity.
GO:0043093; Biological process: FtsZ-dependent cytokinesis.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF03717; PBP_dimer; 1;
PF00905; Transpeptidase; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;

Features [?]

From: FTSI_ECOLI (P0AD68)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     307     307       Acyl-ester intermediate     S  

Additional information [?]

Size range 520-690 amino acids
Related rules None
Fusion None
Comments Second copy in Pseudomonas aeruginosa (penicillin-binding protein 3 homolog), which has probably the same catalytic activity. Does not match FTSI_CAUVN, which seems divergent.


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