HAMAP rule MF_02081

General rule information [?]

Accession	MF_02081
Dates	6-DEC-2016 (Created) 1-JUN-2023 (Last updated, Version 7)

Name	MrdA_transpept

Scope

Bacteria; Pseudomonadota

Template

P0AD65 (MRDA_ECOLI)

Triggered by

HAMAP; MF_02081 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MRDA

Protein name

RecName:		Full=Peptidoglycan D,D-transpeptidase MrdA;
		EC 3.4.16.4;
AltName:		Full=Penicillin-binding protein 2;
		Short=PBP-2;

Gene name

mrdA

Comments [?]

Function	Catalyzes cross-linking of the peptidoglycan cell wall.
Catalytic activity	Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-\|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=3.4.16.4;
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis.

case <Feature:Transmembrane==1>

Subcellular location

Cell inner membrane; Single-pass membrane protein.

end case

Similarity

Belongs to the transpeptidase family. MrdA subfamily.

Keywords [?]

Carboxypeptidase
Cell inner membrane
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Hydrolase
Membrane
Peptidoglycan synthesis
Protease
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0009002; Molecular function: serine-type D-Ala-D-Ala carboxypeptidase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF03717; PBP_dimer; 1;
	PF00905; Transpeptidase; 1;
NCBIfam	TIGR03423; pbp2_mrdA; 1;

Computed features [?]

General

Transmembrane; -; 1; trigger=yes;

Features [?]

From: MRDA_ECOLI (P0AD65)

Key From To Description Tag Condition FTGroup

ACT_SITE 330 330 Acyl-ester intermediate S

Additional information [?]

Size range	580-810 amino acids
Related rules	None
Fusion	None

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