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HAMAP rule MF_02081

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General rule information [?]

Accession MF_02081
Dates 6-DEC-2016 (Created)
1-JUN-2023 (Last updated, Version 7)
Name MrdA_transpept
Bacteria; Pseudomonadota
Template P0AD65 (MRDA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Peptidoglycan D,D-transpeptidase MrdA;
AltName: Full=Penicillin-binding protein 2;
Gene name

Comments [?]

Function Catalyzes cross-linking of the peptidoglycan cell wall.
Catalytic activity Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=;
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
case <Feature:Transmembrane==1>
Subcellular location Cell inner membrane; Single-pass membrane protein.
end case
Similarity Belongs to the transpeptidase family. MrdA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0009002; Molecular function: serine-type D-Ala-D-Ala carboxypeptidase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF03717; PBP_dimer; 1;
PF00905; Transpeptidase; 1;
NCBIfam TIGR03423; pbp2_mrdA; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     330     330       Acyl-ester intermediate     S  

Additional information [?]

Size range 580-810 amino acids
Related rules None
Fusion None