HAMAP rule MF_02081
General rule information
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Accession | MF_02081 |
Dates | 6-DEC-2016 (Created)
1-JUN-2023 (Last updated, Version 7) |
Name | MrdA_transpept |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P0AD65 (MRDA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_02081 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MRDA |
Protein name | RecName: Full=Peptidoglycan D,D-transpeptidase MrdA; EC=3.4.16.4; AltName: Full=Penicillin-binding protein 2; Short=PBP-2; |
Gene name | Name=mrdA; |
Comments
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FUNCTION | Catalyzes cross-linking of the peptidoglycan cell wall. |
CATALYTIC ACTIVITY | Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=3.4.16.4; |
PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
case <Feature:Transmembrane==1> | |
SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the transpeptidase family. MrdA subfamily. |
Keywords
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Carboxypeptidase |
Cell inner membrane |
Cell membrane |
Cell shape |
Cell wall biogenesis/degradation |
Hydrolase |
Membrane |
Peptidoglycan synthesis |
Protease |
Transmembrane |
Transmembrane helix |
Gene Ontology
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GO:0009002; Molecular function:serine-type D-Ala-D-Ala carboxypeptidase activity |
GO:0009252; Biological process:peptidoglycan biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF03717; PBP_dimer; 1; |
Pfam | PF00905; Transpeptidase; 1; |
NCBIfam | TIGR03423; pbp2_mrdA; 1; |
General | Transmembrane; -; 1; |
Features
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From: MRDA_ECOLI (P0AD65) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 330 | 330 | /note="Acyl-ester intermediate" | S |
Additional information
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Size range | 580-810 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |