HAMAP rule MF_02082
General rule information
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Accession | MF_02082 |
Dates | 13-DEC-2016 (Created) 17-FEB-2023 (Last updated, Version 13) |
Name | LysZ |
Scope | Bacteria
Archaea |
Templates | Q4JAQ2 (LYSZ_SULAC); Q980X0 (LYSZ_SACS2); O50147 (LYSZ_THET2): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Sulfolobales>
Protein name |
|
else case <OC:Archaea> and not <OC:Sulfolobales>
Protein name |
|
else case <OC:Deinococcota>
Protein name |
|
else case <OC:Bacteria> and not <OC:Deinococcota>
Protein name |
|
end case
Gene name |
|
Comments
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case <OC:Archaea>
Function | Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis). |
else case <OC:Bacteria>
Function | Catalyzes the phosphorylation of LysW-gamma-alpha-aminoadipate. |
end case
Catalytic activity | RHEA:41944: [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP
EC 2.7.2.17 |
case <OC:Archaea>
Catalytic activity | RHEA:52632: [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP
EC 2.7.2.19 |
end case
Pathway | Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5. |
case <OC:Archaea>
Pathway | Amino-acid biosynthesis; L-arginine biosynthesis. |
end case
Subcellular location | Cytoplasm. |
Similarity | Belongs to the acetylglutamate kinase family. LysZ subfamily. |
Keywords
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case <OC:Archaea>
end case
Gene Ontology
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GO:0016301; Molecular function: kinase activity.
case <OC:Archaea>
GO:0042450; Biological process: arginine biosynthetic process via ornithine.
end case
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.
GO:0005737; Cellular component: cytoplasm.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF00696; AA_kinase; 1; |
PRINTS | PR00474; GLU5KINASE; 1; |
TIGRFAMs | TIGR00761; argB; 1; |
PIRSF | PIRSF000728; NAGK; 1; |
Features
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From: LYSZ_SULAC (Q4JAQ2) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 35 | 36 | /ligand="substrate | G-G | ||||||||
BINDING | 62 | 62 | /ligand="substrate | R | ||||||||
BINDING | 166 | 166 | /ligand="substrate | N | ||||||||
SITE | 5 | 5 | Transition state stabilizer | K | ||||||||
SITE | 223 | 223 | Transition state stabilizer | K |
Additional information
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Size range | 240-330 amino acids |
Related rules | None |
Fusion | None |