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HAMAP rule MF_02082

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General rule information [?]

Accession MF_02082
Dates 13-DEC-2016 (Created)
1-JUN-2023 (Last updated, Version 14)
Name LysZ
Scope(s) Bacteria
Template(s) Q4JAQ2 (LYSZ_SULAC); Q980X0 (LYSZ_SACS2); O50147 (LYSZ_THET2); [ Recover all ]
Triggered by HAMAP; MF_02082 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LYSZ
case <OC:Sulfolobales>
Protein name RecName: Full=[LysW]-aminoadipate/[LysW]-glutamate kinase;
else case <OC:Archaea> and not <OC:Sulfolobales>
Protein name RecName: Full=Putative [LysW]-aminoadipate/[LysW]-glutamate kinase;
else case <OC:Deinococcota>
Protein name RecName: Full=[LysW]-aminoadipate kinase;
else case <OC:Bacteria> and not <OC:Deinococcota>
Protein name RecName: Full=Putative [LysW]-aminoadipate kinase;
end case
Gene name Name=lysZ;

Comments [?]

case <OC:Archaea>
FUNCTIONInvolved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
else case <OC:Bacteria>
FUNCTIONCatalyzes the phosphorylation of LysW-gamma-alpha- aminoadipate.
end case
CATALYTIC ACTIVITY Reaction=[amino-group carrier protein]-C-terminal-N-(1,4- dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L- glutamine + ADP; Xref=Rhea:RHEA:41944, Rhea:RHEA-COMP:9694, Rhea:RHEA-COMP:9712, ChEBI:CHEBI:30616, ChEBI:CHEBI:78499, ChEBI:CHEBI:78503, ChEBI:CHEBI:456216; EC=;
case <OC:Archaea>
CATALYTIC ACTIVITY Reaction=[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L- glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5- phospho-L-glutamyl)-L-glutamate + ADP; Xref=Rhea:RHEA:52632, Rhea:RHEA-COMP:13311, Rhea:RHEA-COMP:13313, ChEBI:CHEBI:30616, ChEBI:CHEBI:136714, ChEBI:CHEBI:136717, ChEBI:CHEBI:456216; EC=;
end case
PATHWAYAmino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5.
case <OC:Archaea>
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis.
end case
SIMILARITYBelongs to the acetylglutamate kinase family. LysZ subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016301; Molecular function:kinase activity
case <OCellular component:Archaea>
GO:0042450; Biological process:arginine biosynthetic process via ornithine
end case
GO:0019878; Biological process:lysine biosynthetic process via aminoadipic acid
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00696; AA_kinase; 1;
NCBIfam TIGR00761; argB; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 35 36 /ligand="substrate" G-G
BINDING 62 62 /ligand="substrate" R
BINDING 166 166 /ligand="substrate" N
SITE 5 5 /note="Transition state stabilizer" K
SITE 223 223 /note="Transition state stabilizer" K

Additional information [?]

Size range 240-330 amino acids
Related rules None
Fusion Nter: None Cter: None

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