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HAMAP rule MF_02082

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General rule information [?]

Accession MF_02082
Dates 13-DEC-2016 (Created)
17-FEB-2023 (Last updated, Version 13)
Name LysZ
Scope
Bacteria
Archaea
Templates Q4JAQ2 (LYSZ_SULAC); Q980X0 (LYSZ_SACS2); O50147 (LYSZ_THET2): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LYSZ
case <OC:Sulfolobales>
Protein name
RecName: Full=[LysW]-aminoadipate/[LysW]-glutamate kinase;
EC 2.7.2.17;
EC 2.7.2.19;
else case <OC:Archaea> and not <OC:Sulfolobales>
Protein name
RecName: Full=Putative [LysW]-aminoadipate/[LysW]-glutamate kinase;
EC 2.7.2.17;
EC 2.7.2.19;
else case <OC:Deinococcota>
Protein name
RecName: Full=[LysW]-aminoadipate kinase;
EC 2.7.2.17;
else case <OC:Bacteria> and not <OC:Deinococcota>
Protein name
RecName: Full=Putative [LysW]-aminoadipate kinase;
EC 2.7.2.17;
end case
Gene name
lysZ

Comments [?]

case <OC:Archaea>
Function Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
else case <OC:Bacteria>
Function Catalyzes the phosphorylation of LysW-gamma-alpha-aminoadipate.
end case
Catalytic activity RHEA:41944: [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP
EC 2.7.2.17
case <OC:Archaea>
Catalytic activity RHEA:52632: [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP
EC 2.7.2.19
end case
Pathway Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5.
case <OC:Archaea>
Pathway Amino-acid biosynthesis; L-arginine biosynthesis.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the acetylglutamate kinase family. LysZ subfamily.

Keywords [?]

Amino-acid biosynthesis
case <OC:Archaea>
Arginine biosynthesis
end case
ATP-binding
Cytoplasm
Kinase
Lysine biosynthesis
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0016301; Molecular function: kinase activity.
case <OC:Archaea>
GO:0042450; Biological process: arginine biosynthetic process via ornithine.
end case
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00696; AA_kinase; 1;
PRINTS PR00474; GLU5KINASE; 1;
TIGRFAMs TIGR00761; argB; 1;
PIRSF PIRSF000728; NAGK; 1;

Features [?]

From: LYSZ_SULAC (Q4JAQ2)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     35     36       /ligand="substrate     G-G  
BINDING     62     62       /ligand="substrate     R  
BINDING     166     166       /ligand="substrate     N  
SITE     5     5       Transition state stabilizer     K  
SITE     223     223       Transition state stabilizer     K  

Additional information [?]

Size range 240-330 amino acids
Related rules None
Fusion None


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