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HAMAP rule MF_02083

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General rule information [?]

Accession MF_02083
Dates 22-DEC-2016 (Created)
1-JUN-2023 (Last updated, Version 11)
Name LysY
Scope(s) Archaea
Template(s) O50146 (LYSY_THET2); Q4JAQ3 (LYSY_SULAC); Q980X1 (LYSY_SACS2); [ Recover all ]
Triggered by HAMAP; MF_02083 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LYSY
case <OC:Sulfolobales>
Protein name RecName: Full=[LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase;
else case <OC:Archaea> and not <OC:Sulfolobales>
Protein name RecName: Full=Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase;
else case <OC:Deinococcota>
Protein name RecName: Full=[LysW]-L-2-aminoadipate 6-phosphate reductase;
else case <OC:Chloroflexota>
Protein name RecName: Full=Putative [LysW]-L-2-aminoadipate 6-phosphate reductase;
end case
Gene name Name=lysY;

Comments [?]

case <OC:Archaea>
FUNCTIONInvolved in both the arginine and lysine biosynthetic pathways.
else case <OC:Bacteria>
FUNCTIONCatalyzes the NADPH-dependent reduction of [LysW]- aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.
end case
CATALYTIC ACTIVITY Reaction=[amino-group carrier protein]-C-terminal-N-(1-carboxy-5- oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1- yl)-L-glutamine + H(+) + NADPH; Xref=Rhea:RHEA:41948, Rhea:RHEA- COMP:9712, Rhea:RHEA-COMP:9714, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78499, ChEBI:CHEBI:78501; EC=;
case <OC:Archaea>
CATALYTIC ACTIVITY Reaction=[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5- semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH; Xref=Rhea:RHEA:52668, Rhea:RHEA-COMP:13313, Rhea:RHEA-COMP:13327, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:136717, ChEBI:CHEBI:136761; EC=
end case
PATHWAYAmino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.
case <OC:Archaea>
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis.
end case
SIMILARITYBelongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016620; Molecular function:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
case <OCellular component:Archaea>
GO:0042450; Biological process:arginine biosynthetic process via ornithine
end case
GO:0019878; Biological process:lysine biosynthetic process via aminoadipic acid
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01118; Semialdhyde_dh; 1;
Pfam PF02774; Semialdhyde_dhC; 1;
NCBIfam TIGR01850; argC; 1;

Features [?]

From: LYSY_THET2 (O50146)
Key From To Description Tag Condition FTGroup
BINDING 12 15 /ligand="NADP(+)"
BINDING 36 38 /ligand="NADP(+)"
ACT_SITE 148 148 C
BINDING 312 312 /ligand="NADP(+)"

Additional information [?]

Size range 330-385 amino acids
Related rules MF_00150
Fusion Nter: None Cter: None
Comments MF_02083 is a subfamily of MF_00150.

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