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Annotation rule MF_02083
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General rule information [?]

Accession MF_02083
Dates 22-DEC-2016 (Created)
27-APR-2020 (Last updated, Version 6)
Name LysY
Scope
Archaea
Bacteria; Chloroflexi
Bacteria; Deinococcus-Thermus
Templates O50146 (LYSY_THET2); Q4JAQ3 (LYSY_SULAC); Q980X1 (LYSY_SACS2): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LYSY
case <OC:Sulfolobales>
Protein name
RecName: Full=[LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase;
EC 1.2.1.-;
EC 1.2.1.103;
else case <OC:Archaea> and not <OC:Sulfolobales>
Protein name
RecName: Full=Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase;
EC 1.2.1.-;
EC 1.2.1.103;
else case <OC:Deinococcus-Thermus>
Protein name
RecName: Full=[LysW]-L-2-aminoadipate 6-phosphate reductase;
EC 1.2.1.103;
else case <OC:Chloroflexi>
Protein name
RecName: Full=Putative [LysW]-L-2-aminoadipate 6-phosphate reductase;
EC 1.2.1.103;
end case
Gene name
lysY

Comments [?]

case <OC:Archaea>
Function Involved in both the arginine and lysine biosynthetic pathways.
else case <OC:Bacteria>
Function Catalyzes the NADPH-dependent reduction of [LysW]-aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.
end case
Catalytic activity RHEA:41948: [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH
EC 1.2.1.103
case <OC:Archaea>
Catalytic activity RHEA:52668: [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH
end case
Pathway Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.
case <OC:Archaea>
Pathway Amino-acid biosynthesis; L-arginine biosynthesis.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.

Keywords [?]

case <OC:Archaea>
end case

Gene Ontology [?]

GO:0016620; Molecular function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor.
case <OC:Archaea>
GO:0042450; Biological process: arginine biosynthetic process via ornithine.
end case
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS01224; ARGC; 1;
Pfam PF01118; Semialdhyde_dh; 1;
PF02774; Semialdhyde_dhC; 1;
TIGRFAMs TIGR01850; argC; 1;

Features [?]

From: LYSY_THET2 (O50146)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     12     15       NADP     [ST]-G-x-[VITA]  
NP_BIND (Optional)     36     38       NADP     S-[RK]-[RK]  
ACT_SITE     148     148             C  
BINDING     312     312       NADP     N  

Additional information [?]

Size range 330-385 amino acids
Related rules MF_00150 (ARGC)
Fusion None
Comments MF_02083 is a subfamily of MF_00150.