HAMAP rule MF_02083

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02083
Accession	MF_02083
Dates	22-DEC-2016 (Created) 13-JUN-2025 (Last updated, Version 14)
Name	LysY
Scope(s)	Archaea Bacteria Chloroflexota Deinococcota
Template(s)	O50146; Q4JAQ3; Q980X1; [ Recover all ]
Triggered by	HAMAP; MF_02083 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LYSY
case <OC:Sulfolobales>
Protein name	RecName: Full=[LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase; EC=1.2.1.103; EC=1.2.1.106;
else case <OC:Archaea> and not <OC:Sulfolobales>
Protein name	RecName: Full=Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase; EC=1.2.1.103; EC=1.2.1.106;
else case <OC:Deinococcota>
Protein name	RecName: Full=[LysW]-L-2-aminoadipate 6-phosphate reductase; EC=1.2.1.103;
else case <OC:Chloroflexota>
Protein name	RecName: Full=Putative [LysW]-L-2-aminoadipate 6-phosphate reductase; EC=1.2.1.103;
end case
Gene name	Name=lysY;

Comments [?]

case <OC:Archaea>
FUNCTION	Involved in both the arginine and lysine biosynthetic pathways.
else case <OC:Bacteria>
FUNCTION	Catalyzes the NADPH-dependent reduction of [LysW]- aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.
end case
CATALYTIC ACTIVITY	Reaction=[amino-group carrier protein]-C-terminal-N-(1-carboxy-5- oxopentan-1-yl)-L-glutamine + phosphate + NADP(+) = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1- yl)-L-glutamine + NADPH + H(+); Xref=Rhea:RHEA:41948, Rhea:RHEA- COMP:9712, Rhea:RHEA-COMP:9714, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78499, ChEBI:CHEBI:78501; EC=1.2.1.103;
case <OC:Archaea>
CATALYTIC ACTIVITY	Reaction=[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5- semialdehyde)-L-glutamate + phosphate + NADP(+) = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + NADPH + H(+); Xref=Rhea:RHEA:52668, Rhea:RHEA-COMP:13313, Rhea:RHEA-COMP:13327, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:136717, ChEBI:CHEBI:136761; EC=1.2.1.106
end case
PATHWAY	Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.
case <OC:Archaea>
PATHWAY	Amino-acid biosynthesis; L-arginine biosynthesis.
end case
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016620; Molecular function:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
case <OCellular component:Archaea>
GO:0042450; Biological process:L-arginine biosynthetic process via ornithine
end case
GO:0019878; Biological process:lysine biosynthetic process via aminoadipic acid
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: LYSY_THET2 (O50146)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"

[ST]-G-x-[VITA]

BINDING

/ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"

S-[RK]-[RK]

ACT_SITE

148

BINDING

312

/ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"

Additional information [?]