HAMAP rule MF_02083
General rule information
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Accession | MF_02083 |
Dates | 22-DEC-2016 (Created)
1-JUN-2023 (Last updated, Version 11) |
Name | LysY |
Scope(s) |
Archaea Bacteria Chloroflexota Deinococcota |
Template(s) | O50146 (LYSY_THET2); Q4JAQ3 (LYSY_SULAC); Q980X1 (LYSY_SACS2); [ Recover all ] |
Triggered by |
HAMAP; MF_02083 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | LYSY |
case <OC:Sulfolobales> | |
Protein name | RecName: Full=[LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase; EC=1.2.1.103; EC=1.2.1.106; |
else case <OC:Archaea> and not <OC:Sulfolobales> | |
Protein name | RecName: Full=Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase; EC=1.2.1.103; EC=1.2.1.106; |
else case <OC:Deinococcota> | |
Protein name | RecName: Full=[LysW]-L-2-aminoadipate 6-phosphate reductase; EC=1.2.1.103; |
else case <OC:Chloroflexota> | |
Protein name | RecName: Full=Putative [LysW]-L-2-aminoadipate 6-phosphate reductase; EC=1.2.1.103; |
end case | |
Gene name | Name=lysY; |
Comments
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case <OC:Archaea> | |
FUNCTION | Involved in both the arginine and lysine biosynthetic pathways. |
else case <OC:Bacteria> | |
FUNCTION | Catalyzes the NADPH-dependent reduction of [LysW]- aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde. |
end case | |
CATALYTIC ACTIVITY | Reaction=[amino-group carrier protein]-C-terminal-N-(1-carboxy-5- oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1- yl)-L-glutamine + H(+) + NADPH; Xref=Rhea:RHEA:41948, Rhea:RHEA- COMP:9712, Rhea:RHEA-COMP:9714, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78499, ChEBI:CHEBI:78501; EC=1.2.1.103; |
case <OC:Archaea> | |
CATALYTIC ACTIVITY | Reaction=[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5- semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH; Xref=Rhea:RHEA:52668, Rhea:RHEA-COMP:13313, Rhea:RHEA-COMP:13327, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:136717, ChEBI:CHEBI:136761; EC=1.2.1.106 |
end case | |
PATHWAY | Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5. |
case <OC:Archaea> | |
PATHWAY | Amino-acid biosynthesis; L-arginine biosynthesis. |
end case | |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. |
Keywords
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Amino-acid biosynthesis | |
case <OC:Archaea> | |
Arginine biosynthesis | |
end case | |
Cytoplasm | |
Lysine biosynthesis | |
NADP | |
Oxidoreductase |
Gene Ontology
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GO:0016620; Molecular function:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | |
case <OCellular component:Archaea> | |
GO:0042450; Biological process:arginine biosynthetic process via ornithine | |
end case | |
GO:0019878; Biological process:lysine biosynthetic process via aminoadipic acid | |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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PROSITE | PS01224; ARGC; 1; |
Pfam | PF01118; Semialdhyde_dh; 1; |
Pfam | PF02774; Semialdhyde_dhC; 1; |
NCBIfam | TIGR01850; argC; 1; |
Features
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From: LYSY_THET2 (O50146) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 12 | 15 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[ST]-G-x-[VITA] | ||||||||
BINDING | 36 | 38 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
S-[RK]-[RK] | ||||||||
ACT_SITE | 148 | 148 | C | |||||||||
BINDING | 312 | 312 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
N |
Additional information
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Size range | 330-385 amino acids |
Related rules |
MF_00150 |
Fusion | Nter: None Cter: None |
Comments | MF_02083 is a subfamily of MF_00150. |