HAMAP rule MF_02089
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_02089 |
| Accession | MF_02089 |
| Dates | 23-MAR-2017 (Created)
3-SEP-2024 (Last updated, Version 8) |
| Name | QueH |
| Scope(s) |
Bacteria |
| Template(s) | A0A0H3JUG6 (QUEH_STAAM); Q7VYQ1 (QUEH_BORPE); Q3Z8V0 (QUEH_DEHM1); Q0I1Q0 (QUEH_HISS1); A0A0H2VKG8 (QUEH_STAES); Q9A1K3 (QUEH_STRP1); Q9WZJ0 (QUEH_THEMA); O24926 (QUEH_HELPY); [ Recover all ] |
| Triggered by |
HAMAP; MF_02089 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | QUEH |
| Protein name | RecName: Full=Epoxyqueuosine reductase QueH; EC=1.17.99.6; AltName: Full=Queuosine biosynthesis protein QueH; |
| Gene name | Name=queH; |
Comments
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| FUNCTION | Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). |
| CATALYTIC ACTIVITY | Reaction=epoxyqueuosine(34) in tRNA + AH2 = queuosine(34) in tRNA + A + H2O; Xref=Rhea:RHEA:32159, Rhea:RHEA-COMP:18571, Rhea:RHEA- COMP:18582, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:194431, ChEBI:CHEBI:194443; EC=1.17.99.6; |
| PATHWAY | tRNA modification; tRNA-queuosine biosynthesis. |
| SIMILARITY | Belongs to the QueH family. |
Keywords
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| case <FTGroup:1> | |
| 4Fe-4S | |
| Iron | |
| Iron-sulfur | |
| Metal-binding | |
| end case | |
| Disulfide bond | |
| Oxidoreductase | |
| Queuosine biosynthesis | |
| Redox-active center | |
| tRNA processing | |
Gene Ontology
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| GO:0052693; Molecular function:epoxyqueuosine reductase activity | |
| case <FTGroup:1> | |
| GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding | |
| end case | |
| GO:0008616; Biological process:queuosine biosynthetic process | |
| GO:0006400; Biological process:tRNA modification | |
Cross-references
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| Pfam | PF02677; DUF208; 1; |
Features
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| From: QUEH_STAAM (A0A0H3JUG6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 43 | 43 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 44 | 44 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 129 | 129 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 132 | 132 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| DISULFID | 211 | 213 | /note="Redox-active" | C-x*-C | ||||||||
Additional information
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| Size range | 170-370 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Longer C-terminal domain in some species. |