HAMAP logo

HAMAP rule MF_02089

Send feedback

General rule information [?]

Accession MF_02089
Dates 23-MAR-2017 (Created)
31-JAN-2024 (Last updated, Version 7)
Name QueH
Scope(s) Bacteria
Template(s) A0A0H3JUG6 (QUEH_STAAM); Q7VYQ1 (QUEH_BORPE); Q3Z8V0 (QUEH_DEHM1); Q0I1Q0 (QUEH_HISS1); A0A0H2VKG8 (QUEH_STAES); Q9A1K3 (QUEH_STRP1); Q9WZJ0 (QUEH_THEMA); O24926 (QUEH_HELPY); [ Recover all ]
Triggered by HAMAP; MF_02089 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier QUEH
Protein name RecName: Full=Epoxyqueuosine reductase QueH;
AltName: Full=Queuosine biosynthesis protein QueH;
Gene name Name=queH;

Comments [?]

FUNCTIONCatalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
CATALYTIC ACTIVITY Reaction=AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA; Xref=Rhea:RHEA:32159, Rhea:RHEA-COMP:18571, Rhea:RHEA- COMP:18582, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:194431, ChEBI:CHEBI:194443; EC=;
PATHWAYtRNA modification; tRNA-queuosine biosynthesis.
SIMILARITYBelongs to the QueH family.

Keywords [?]

Gene Ontology [?]

GO:0052693; Molecular function:epoxyqueuosine reductase activity
case <FTGroup:1>
GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding
end case
GO:0008616; Biological process:queuosine biosynthetic process
GO:0006400; Biological process:tRNA modification

Cross-references [?]

Pfam PF02677; DUF208; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 43 43 /ligand="[4Fe-4S] cluster"
C 1
BINDING 44 44 /ligand="[4Fe-4S] cluster"
C 1
BINDING 129 129 /ligand="[4Fe-4S] cluster"
C 1
BINDING 132 132 /ligand="[4Fe-4S] cluster"
C 1
DISULFID 211 213 /note="Redox-active" C-x*-C

Additional information [?]

Size range 170-370 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Longer C-terminal domain in some species.

View rule in raw text format (no links)