HAMAP rule MF_02089

General rule information [?]

Accession	MF_02089
Dates	23-MAR-2017 (Created) 9-MAR-2023 (Last updated, Version 6)

Name

QueH

Scope

Bacteria

Templates

A0A0H3JUG6 (QUEH_STAAM); Q7VYQ1 (QUEH_BORPE); Q3Z8V0 (QUEH_DEHM1); Q0I1Q0 (QUEH_HISS1); A0A0H2VKG8 (QUEH_STAES); Q9A1K3 (QUEH_STRP1); Q9WZJ0 (QUEH_THEMA); O24926 (QUEH_HELPY): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

QUEH

Protein name

RecName:		Full=Epoxyqueuosine reductase QueH;
		EC 1.17.99.6;
AltName:		Full=Queuosine biosynthesis protein QueH;

Gene name

queH

Comments [?]

Function	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
Catalytic activity	RHEA:32159: AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA EC 1.17.99.6
Pathway	tRNA modification; tRNA-queuosine biosynthesis.
Similarity	Belongs to the QueH family.

Keywords [?]

case <FTGroup:1>

end case

Gene Ontology [?]

GO:0052693; Molecular function: epoxyqueuosine reductase activity.

case <FTGroup:1>

GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.

end case

GO:0008616; Biological process: queuosine biosynthetic process.
GO:0008033; Biological process: tRNA processing.

Cross-references [?]

Pfam	PF02677; DUF208; 1;

Features [?]

From: QUEH_STAAM (A0A0H3JUG6)

Key From To Description Tag Condition FTGroup

BINDING 43 43 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

BINDING 44 44 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

BINDING 129 129 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

BINDING 132 132 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

DISULFID 211 213 Redox-active C-x*-C

Additional information [?]

Size range	170-370 amino acids
Related rules	None
Fusion	None
Comments	Longer C-terminal domain in some species.