HAMAP rule MF_02092
General rule information
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Accession | MF_02092 |
Dates | 12-JUL-2017 (Created)
26-JAN-2023 (Last updated, Version 6) |
Name | DLDH_Dld |
Scope(s) |
Bacteria |
Template(s) | P06149 (DLD_ECOLI); Q8NRY8 (DLD_CORGL); [ Recover all ] |
Triggered by |
HAMAP; MF_02092 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DLD |
Protein name | RecName: Full=Quinone-dependent D-lactate dehydrogenase; EC=1.1.5.12; AltName: Full=D-lactate dehydrogenase; Short=D-LDH; |
Gene name | Name=dld; |
Comments
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FUNCTION | Catalyzes the oxidation of D-lactate to pyruvate. |
CATALYTIC ACTIVITY | Reaction=(R)-lactate + a quinone = a quinol + pyruvate; Xref=Rhea:RHEA:51468, ChEBI:CHEBI:15361, ChEBI:CHEBI:16004, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.12; |
COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>) | |
SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. |
else | |
SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
end case | |
SIMILARITY | Belongs to the quinone-dependent D-lactate dehydrogenase family. |
Keywords
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case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>) | |
Cell inner membrane | |
end case | |
Cell membrane | |
FAD | |
Flavoprotein | |
Membrane | |
Oxidoreductase | |
Quinone |
Gene Ontology
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GO:0016901; Molecular function:oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor |
GO:0050660; Molecular function:flavin adenine dinucleotide binding |
GO:0019516; Biological process:lactate oxidation |
GO:0031234; Cellular component:extrinsic component of cytoplasmic side of plasma membrane |
Cross-references
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PROSITE | PS51387; FAD_PCMH; 1; |
Pfam | PF01565; FAD_binding_4; 1; |
Pfam | PF09330; Lact-deh-memb; 1; |
PIRSF | PIRSF000101; D-lactate_dh; 1; |
Features
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From: DLD_ECOLI (P06149) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 76 | 80 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
[AS]-[AS]-[NK]-T-[GS] | ||||||||
BINDING | 84 | 85 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
G-S | ||||||||
BINDING | 143 | 143 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
G | ||||||||
BINDING | 150 | 150 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
[ST] | ||||||||
BINDING | 160 | 160 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
G | ||||||||
BINDING | 262 | 262 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
[VLI] |
Additional information
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Size range | 550-610 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |