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Annotation rule MF_02092
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General rule information [?]

Accession MF_02092
Dates 12-JUL-2017 (Created)
20-NOV-2019 (Last updated, Version 3)
Name DLDH_Dld
Scope
Bacteria
Templates P06149 (DLD_ECOLI); Q8NRY8 (DLD_CORGL): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DLD
Protein name
RecName: Full=Quinone-dependent D-lactate dehydrogenase;
EC 1.1.5.12;
AltName: Full=D-lactate dehydrogenase;
Short=D-LDH;
Gene name
dld

Comments [?]

Function Catalyzes the oxidation of D-lactate to pyruvate.
Catalytic activity RHEA:51468: (R)-lactate + a quinone = a quinol + pyruvate
EC 1.1.5.12
Cofactor FAD
case <OC:Proteobacteria> or (defined <Property:Membrane> and <Property:Membrane=2>)
Subcellular location Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
else
Subcellular location Cell membrane; Peripheral membrane protein; Cytoplasmic side.
end case
Similarity Belongs to the quinone-dependent D-lactate dehydrogenase family.

Keywords [?]

case <OC:Proteobacteria> or (defined <Property:Membrane> and <Property:Membrane=2>)
end case

Gene Ontology [?]

GO:0016901; Molecular function: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0019516; Biological process: lactate oxidation.
GO:0031234; Cellular component: extrinsic component of cytoplasmic side of plasma membrane.

Cross-references [?]

PROSITE PS51387; FAD_PCMH; 1; trigger=PRU00718;
Pfam PF01565; FAD_binding_4; 1;
PF09330; Lact-deh-memb; 1;
PIRSF PIRSF000101; D-lactate_dh; 1;

Features [?]

From: DLD_ECOLI (P06149)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     76     80       FAD     [AS]-[AS]-[NK]-T-[GS]  
NP_BIND     84     85       FAD     G-S  
BINDING     143     143       FAD; via amide nitrogen     G  
BINDING     150     150       FAD     [ST]  
BINDING     160     160       FAD; via amide nitrogen     G  
BINDING     262     262       FAD; via amide nitrogen and carbonyl oxygen     [VLI]  

Additional information [?]

Size range 550-610 amino acids
Related rules None
Fusion None