HAMAP rule MF_02093

General rule information [?]

Accession	MF_02093
Dates	29-AUG-2017 (Created) 1-JUN-2023 (Last updated, Version 8)

Name	Beta_carotene_diox

Scope

Bacteria

Archaea

Template

Q4PNI0 (BLH_UNCMB)

Triggered by

HAMAP; MF_02093 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

BLH

Protein name

RecName:		Full=Probable beta-carotene 15,15'-dioxygenase;
		EC 1.13.11.63;

Comments [?]

Function	Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
Catalytic activity	RHEA:32887: all-trans-beta-carotene + O2 = 2 all-trans-retinal EC 1.13.11.63
Cofactor	Fe(2+)
Subcellular location	Cell membrane; Multi-pass membrane protein.
Similarity	Belongs to the Brp/Blh beta-carotene diooxygenase family.

Keywords [?]

Cell membrane
Dioxygenase
Iron
Membrane
Metal-binding
Oxidoreductase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0005506; Molecular function: iron ion binding.
GO:0010436; Molecular function: carotenoid dioxygenase activity.
GO:0016121; Biological process: carotene catabolic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF15461; BCD; 1;
NCBIfam	TIGR03753; blh_monoox; 1;

Computed features [?]

General

Transmembrane; -; 7-10; trigger=yes;

Features [?]

From: BLH_UNCMB (Q4PNI0)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 21 21 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 H 1

BINDING (Optional) 78 78 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 H 1

BINDING (Optional) 188 188 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 H 1

BINDING (Optional) 192 192 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 H 1

Additional information [?]

Size range	240-390 amino acids
Related rules	None
Fusion	None

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