HAMAP rule MF_02093
General rule information
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| Accession | MF_02093 |
| Dates | 29-AUG-2017 (Created)
1-JUN-2023 (Last updated, Version 8) |
| Name | Beta_carotene_diox |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q4PNI0 (BLH_UNCMB); [ Recover all ] |
| Triggered by |
HAMAP; MF_02093 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | BLH |
| Protein name | RecName: Full=Probable beta-carotene 15,15'-dioxygenase; EC=1.13.11.63; |
Comments
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| FUNCTION | Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal. |
| CATALYTIC ACTIVITY | Reaction=all-trans-beta-carotene + O2 = 2 all-trans-retinal; Xref=Rhea:RHEA:32887, ChEBI:CHEBI:15379, ChEBI:CHEBI:17579, ChEBI:CHEBI:17898; EC=1.13.11.63; |
| COFACTOR | Name=Fe(2+); Xref=ChEBI:CHEBI:29033; |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the Brp/Blh beta-carotene diooxygenase family. |
Keywords
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| Cell membrane |
| Dioxygenase |
| Iron |
| Membrane |
| Metal-binding |
| Oxidoreductase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| GO:0005506; Molecular function:iron ion binding |
| GO:0010436; Molecular function:carotenoid dioxygenase activity |
| GO:0016121; Biological process:carotene catabolic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF15461; BCD; 1; |
| NCBIfam | TIGR03753; blh_monoox; 1; |
| General | Transmembrane; -; 7-10; |
Features
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| From: BLH_UNCMB (Q4PNI0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 21 | 21 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
H | 1 | |||||||
| BINDING | 78 | 78 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
H | 1 | |||||||
| BINDING | 188 | 188 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
H | 1 | |||||||
| BINDING | 192 | 192 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
H | 1 | |||||||
Additional information
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| Size range | 240-390 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |