HAMAP rule MF_02095
General rule information
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| Accession | MF_02095 |
| Dates | 13-OCT-2017 (Created)
1-JUN-2023 (Last updated, Version 8) |
| Name | CysQ |
| Scope(s) |
Bacteria |
| Template(s) | P22255 (CYSQ_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_02095 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CYSQ |
| Protein name | RecName: Full=3'(2'),5'-bisphosphate nucleotidase CysQ; EC=3.1.3.7; AltName: Full=3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; AltName: Full=3'-phosphoadenosine 5'-phosphate phosphatase; Short=PAP phosphatase; |
| Gene name | Name=cysQ; |
Comments
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| FUNCTION | Converts adenosine-3',5'-bisphosphate (PAP) to AMP. |
| CATALYTIC ACTIVITY | Reaction=adenosine 3',5'-bisphosphate + H2O = AMP + phosphate; Xref=Rhea:RHEA:10040, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58343, ChEBI:CHEBI:456215; EC=3.1.3.7; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>) | |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. |
| else | |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| end case | |
| SIMILARITY | Belongs to the inositol monophosphatase superfamily. CysQ family. |
Keywords
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| case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>) | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Hydrolase | |
| Magnesium | |
| Membrane | |
| Metal-binding | |
Gene Ontology
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| GO:0008441; Molecular function:3'(2'),5'-bisphosphate nucleotidase activity |
| GO:0000287; Molecular function:magnesium ion binding |
Cross-references
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| PROSITE | PS00629; IMP_1; 1; |
| PROSITE | PS00630; IMP_2; 1; |
| Pfam | PF00459; Inositol_P; 1; |
| PRINTS | PR00377; IMPHPHTASES; 1; |
| NCBIfam | TIGR01331; bisphos_cysQ; 1; |
Features
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| From: CYSQ_ECOLI (P22255) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 85 | 88 | /ligand="substrate" | [LIV]-D-G-T | ||||||||
| BINDING | 64 | 64 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
E | ||||||||
| BINDING | 83 | 83 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 83 | 83 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 85 | 85 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
[LIV] | ||||||||
| BINDING | 86 | 86 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 205 | 205 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 64 | 64 | /ligand="substrate" | E | ||||||||
| BINDING | 205 | 205 | /ligand="substrate" | D | ||||||||
Additional information
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| Size range | 220-320 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |