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HAMAP rule MF_02097

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General rule information [?]

Accession MF_02097
Dates 31-OCT-2017 (Created)
12-MAR-2024 (Last updated, Version 9)
Name Carnitine_monoox_A
Scope(s) Bacteria
Pseudomonadota
Template(s) D0C9N6 (CNTA_ACIB2); F0KFI5 (CNTA_ACICP); P0ABR7 (CNTA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02097 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CNTA
Protein name RecName: Full=Carnitine monooxygenase oxygenase subunit;
                 EC=1.14.13.239;
AltName: Full=Carnitine monooxygenase alpha subunit;

Comments [?]

FUNCTIONConverts carnitine to trimethylamine and malic semialdehyde.
CATALYTIC ACTIVITY Reaction=(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4- oxobutanoate + H2O + NAD(+) + trimethylamine; Xref=Rhea:RHEA:55396, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16347, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58389, ChEBI:CHEBI:138809; EC=1.14.13.239;
CATALYTIC ACTIVITY Reaction=(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4- oxobutanoate + H2O + NADP(+) + trimethylamine; Xref=Rhea:RHEA:55368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58389, ChEBI:CHEBI:138809; EC=1.14.13.239;
case <FTGroup:1>
COFACTOR Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 [2Fe-2S] cluster per subunit.;
end case
COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per subunit
PATHWAYAmine and polyamine metabolism; carnitine metabolism.
SUBUNITComposed of an oxygenase subunit and a reductase subunit.
SIMILARITYBelongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0016709; Molecular function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
case <FTGroup:1>
GO:0051537; Molecular function:2 iron, 2 sulfur cluster binding
end case
GO:0009437; Biological process:carnitine metabolic process

Cross-references [?]

PROSITE PS51296; RIESKE; 1;
PROSITE PS00570; RING_HYDROXYL_ALPHA; 1;
Pfam PF00355; Rieske; 1;
Pfam PF00848; Ring_hydroxyl_A; 1;
PRINTS PR00090; RNGDIOXGNASE; 1;

Features [?]

From: CNTA_ACIB2 (D0C9N6)
Key From To Description Tag Condition FTGroup
BINDING 86 86 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C 1
BINDING 88 88 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
H 1
BINDING 106 106 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C 1
BINDING 109 109 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
H 1
BINDING 208 208 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
H
BINDING 213 213 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
H
BINDING 323 323 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
D

Additional information [?]

Size range 365-405 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments See MF_02098 for the reductase subunit.



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