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Annotation rule MF_02097
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General rule information [?]

Accession MF_02097
Dates 31-OCT-2017 (Created)
20-NOV-2019 (Last updated, Version 4)
Name Carnitine_monoox_A
Bacteria; Proteobacteria
Templates D0C9N6 (CNTA_ACIB2); F0KFI5 (CNTA_ACICP); P0ABR7 (CNTA_ECOLI): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Carnitine monooxygenase oxygenase subunit;
AltName: Full=Carnitine monooxygenase alpha subunit;

Comments [?]

Function Converts carnitine to trimethylamine and malic semialdehyde.
Catalytic activity RHEA:55396: (R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine
RHEA:55368: (R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine
case <FTGroup:1>
Cofactor [2Fe-2S] cluster
Note: Binds 1 [2Fe-2S] cluster per subunit.
end case
Cofactor Fe cation
Note: Binds 1 Fe cation per subunit
Pathway Amine and polyamine metabolism; carnitine metabolism.
Subunit Composed of an oxygenase subunit and a reductase subunit.
Similarity Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0016709; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen.
case <FTGroup:1>
GO:0051537; Molecular function: 2 iron, 2 sulfur cluster binding.
end case

Cross-references [?]

PROSITE PS51296; RIESKE; 1; trigger=PRU00628;
Pfam PF00355; Rieske; 1;
PF00848; Ring_hydroxyl_A; 1;

Features [?]

From: CNTA_ACIB2 (D0C9N6)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     86     86       Iron-sulfur (2Fe-2S)     C   1
METAL     88     88       Iron-sulfur (2Fe-2S); via pros nitrogen     H   1
METAL     106     106       Iron-sulfur (2Fe-2S)     C   1
METAL     109     109       Iron-sulfur (2Fe-2S); via pros nitrogen     H   1
METAL     208     208       Iron; via tele nitrogen     H  
METAL     213     213       Iron; via tele nitrogen     H  
METAL     323     323       Iron     D  

Additional information [?]

Size range 365-405 amino acids
Related rules None
Fusion None
Comments See MF_02098 for the reductase subunit.