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HAMAP rule MF_02097

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General rule information [?]

Accession MF_02097
Dates 31-OCT-2017 (Created)
26-JAN-2023 (Last updated, Version 8)
Name Carnitine_monoox_A
Scope
Bacteria; Pseudomonadota
Templates D0C9N6 (CNTA_ACIB2); F0KFI5 (CNTA_ACICP); P0ABR7 (CNTA_ECOLI): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CNTA
Protein name
RecName: Full=Carnitine monooxygenase oxygenase subunit;
EC 1.14.13.239;
AltName: Full=Carnitine monooxygenase alpha subunit;

Comments [?]

Function Converts carnitine to trimethylamine and malic semialdehyde.
Catalytic activity RHEA:55396: (R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine
EC 1.14.13.239
RHEA:55368: (R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine
EC 1.14.13.239
case <FTGroup:1>
Cofactor [2Fe-2S] cluster
Note: Binds 1 [2Fe-2S] cluster per subunit.
end case
Cofactor Fe cation
Note: Binds 1 Fe cation per subunit
Pathway Amine and polyamine metabolism; carnitine metabolism.
Subunit Composed of an oxygenase subunit and a reductase subunit.
Similarity Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily.

Keywords [?]

case <FTGroup:1>
2Fe-2S
Iron-sulfur
end case
Iron
Metal-binding
NAD
NADP
Oxidoreductase

Gene Ontology [?]

GO:0016709; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen.
case <FTGroup:1>
GO:0051537; Molecular function: 2 iron, 2 sulfur cluster binding.
end case

Cross-references [?]

PROSITE PS51296; RIESKE; 1; trigger=PRU00628;
PS00570; RING_HYDROXYL_ALPHA; 1;
Pfam PF00355; Rieske; 1;
PF00848; Ring_hydroxyl_A; 1;
PRINTS PR00090; RNGDIOXGNASE; 1;

Features [?]

From: CNTA_ACIB2 (D0C9N6)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     86     86       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1
BINDING     88     88       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     H   1
BINDING     106     106       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1
BINDING     109     109       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     H   1
BINDING     208     208       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     H  
BINDING     213     213       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     H  
BINDING     323     323       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     D  

Additional information [?]

Size range 365-405 amino acids
Related rules None
Fusion None
Comments See MF_02098 for the reductase subunit.


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