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Annotation rule MF_02097 |
Accession | MF_02097 |
Dates | 31-OCT-2017 (Created) 19-NOV-2022 (Last updated, Version 7) |
Name | Carnitine_monoox_A |
Scope | Bacteria; Proteobacteria |
Templates | D0C9N6 (CNTA_ACIB2); F0KFI5 (CNTA_ACICP); P0ABR7 (CNTA_ECOLI): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Function | Converts carnitine to trimethylamine and malic semialdehyde. |
Catalytic activity | RHEA:55396: (R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine
EC 1.14.13.239 |
RHEA:55368: (R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine
EC 1.14.13.239 |
Cofactor | [2Fe-2S] cluster Note: Binds 1 [2Fe-2S] cluster per subunit. |
Cofactor | Fe cation Note: Binds 1 Fe cation per subunit |
Pathway | Amine and polyamine metabolism; carnitine metabolism. |
Subunit | Composed of an oxygenase subunit and a reductase subunit. |
Similarity | Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily. |
PROSITE | PS51296; RIESKE; 1; trigger=PRU00628; |
PS00570; RING_HYDROXYL_ALPHA; 1; | |
Pfam | PF00355; Rieske; 1; |
PF00848; Ring_hydroxyl_A; 1; | |
PRINTS | PR00090; RNGDIOXGNASE; 1; |
From: CNTA_ACIB2 (D0C9N6) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 86 | 86 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 | C | 1 | |||||||
BINDING | 88 | 88 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 | H | 1 | |||||||
BINDING | 106 | 106 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 | C | 1 | |||||||
BINDING | 109 | 109 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 | H | 1 | |||||||
BINDING | 208 | 208 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | H | ||||||||
BINDING | 213 | 213 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | H | ||||||||
BINDING | 323 | 323 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | D |
Size range | 365-405 amino acids |
Related rules | None |
Fusion | None |
Comments | See MF_02098 for the reductase subunit. |