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Annotation rule MF_02103
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General rule information [?]

Accession MF_02103
Dates 12-AUG-2009 (Created)
20-NOV-2019 (Last updated, Version 11)
Name LutB
Bacteria; Firmicutes
Templates O07021 (LUTB_BACSU); Q81GA4 (LUTB_BACCR): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Lactate utilization protein B;
Gene name

Comments [?]

Function Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate.
Similarity Belongs to the LutB/YkgF family.

Keywords [?]

Gene Ontology [?]

GO:0051536; Molecular function: iron-sulfur cluster binding.
GO:0006089; Biological process: lactate metabolic process.
GO:0019516; Biological process: lactate oxidation.

Cross-references [?]

PROSITE PS00198; 4FE4S_FER_1; 2;
PS51379; 4FE4S_FER_2; 2;
Pfam PF02589; DUF162; 1;
TIGRFAMs TIGR00273; TIGR00273; 1;

Features [?]

From: LUTB_BACSU (O07021)
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     304     334       4Fe-4S ferredoxin-type 1        
DOMAIN     353     382       4Fe-4S ferredoxin-type 2        
METAL     313     313       Iron-sulfur 1 (4Fe-4S)     C  
METAL     316     316       Iron-sulfur 1 (4Fe-4S)     C  
METAL     319     319       Iron-sulfur 1 (4Fe-4S)     C  
METAL     323     323       Iron-sulfur 2 (4Fe-4S)     C  
METAL     366     366       Iron-sulfur 2 (4Fe-4S)     C  
METAL     369     369       Iron-sulfur 2 (4Fe-4S)     C  
METAL     373     373       Iron-sulfur 1 (4Fe-4S)     C  

Additional information [?]

Size range 468-485 amino acids
Related rules None
Fusion None
Comments The E.coli ykgEFG operon is a clear homolog of the B.subtilis lutABC operon, however it is not able of restoring L-lactate utilization to the B.subtilis mutant for lutABC operon (PubMed=19201793). Thus, ykgEFG operon may contribute to lactate catabolism in E.coli, but under conditions other than those tested, or alternatively, the ykgEFG operon may be responsible for the catabolism of a metabolite other than (but perhaps related to) lactate in E.coli. That's why the profile was not extended to Proteobacteria and this family rule is currently restricted to Firmicutes (in fact seed alignment only contains Bacillales), waiting for characterization in E.coli.