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HAMAP rule MF_02103

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General rule information [?]

Accession MF_02103
Dates 12-AUG-2009 (Created)
1-JUN-2023 (Last updated, Version 17)
Name LutB
Scope(s) Bacteria
Bacillota
Template(s) O07021 (LUTB_BACSU); Q81GA4 (LUTB_BACCR); [ Recover all ]
Triggered by HAMAP; MF_02103 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LUTB
Protein name RecName: Full=Lactate utilization protein B;
Gene name Name=lutB;

Comments [?]

FUNCTIONIs involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate.
SIMILARITYBelongs to the LutB/YkgF family.

Keywords [?]


Gene Ontology [?]

GO:0051536; Molecular function:iron-sulfur cluster binding
GO:0006089; Biological process:lactate metabolic process
GO:0019516; Biological process:lactate oxidation

Cross-references [?]

PROSITE PS00198; 4FE4S_FER_1; 2;
PROSITE PS51379; 4FE4S_FER_2; 2;
Pfam PF02589; DUF162; 1;
NCBIfam TIGR00273; TIGR00273; 1;

Features [?]

From: LUTB_BACSU (O07021)
Key From To Description Tag Condition FTGroup
DOMAIN 304 334 /note="4Fe-4S ferredoxin-type 1"
DOMAIN 353 382 /note="4Fe-4S ferredoxin-type 2"
BINDING 313 313 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="1"
C
BINDING 316 316 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="1"
C
BINDING 319 319 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="1"
C
BINDING 323 323 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="2"
C
BINDING 366 366 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="2"
C
BINDING 369 369 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="2"
C
BINDING 373 373 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="1"
C

Additional information [?]

Size range 468-485 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The E.coli ykgEFG operon is a clear homolog of the B.subtilis lutABC operon, however it is not able of restoring L-lactate utilization to the B.subtilis mutant for lutABC operon (PubMed=19201793). Thus, ykgEFG operon may contribute to lactate catabolism in E.coli, but under conditions other than those tested, or alternatively, the ykgEFG operon may be responsible for the catabolism of a metabolite other than (but perhaps related to) lactate in E.coli. That's why the profile was not extended to Pseudomonadota and this family rule is currently restricted to Bacillota (in fact seed alignment only contains Bacillales), waiting for characterization in E.coli.



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