HAMAP rule MF_02103
General rule information
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| Accession | MF_02103 |
| Dates | 12-AUG-2009 (Created)
1-JUN-2023 (Last updated, Version 17) |
| Name | LutB |
| Scope(s) |
Bacteria Bacillota |
| Template(s) | O07021 (LUTB_BACSU); Q81GA4 (LUTB_BACCR); [ Recover all ] |
| Triggered by |
HAMAP; MF_02103 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LUTB |
| Protein name | RecName: Full=Lactate utilization protein B; |
| Gene name | Name=lutB; |
Comments
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| FUNCTION | Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate. |
| SIMILARITY | Belongs to the LutB/YkgF family. |
Keywords
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Gene Ontology
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| GO:0051536; Molecular function:iron-sulfur cluster binding |
| GO:0006089; Biological process:lactate metabolic process |
| GO:0019516; Biological process:lactate oxidation |
Cross-references
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| PROSITE | PS00198; 4FE4S_FER_1; 2; |
| PROSITE | PS51379; 4FE4S_FER_2; 2; |
| Pfam | PF02589; DUF162; 1; |
| NCBIfam | TIGR00273; TIGR00273; 1; |
Features
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| From: LUTB_BACSU (O07021) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | 304 | 334 | /note="4Fe-4S ferredoxin-type 1" | |||||||||
| DOMAIN | 353 | 382 | /note="4Fe-4S ferredoxin-type 2" | |||||||||
| BINDING | 313 | 313 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1" |
C | ||||||||
| BINDING | 316 | 316 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1" |
C | ||||||||
| BINDING | 319 | 319 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1" |
C | ||||||||
| BINDING | 323 | 323 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2" |
C | ||||||||
| BINDING | 366 | 366 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2" |
C | ||||||||
| BINDING | 369 | 369 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2" |
C | ||||||||
| BINDING | 373 | 373 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1" |
C | ||||||||
Additional information
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| Size range | 468-485 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The E.coli ykgEFG operon is a clear homolog of the B.subtilis lutABC operon, however it is not able of restoring L-lactate utilization to the B.subtilis mutant for lutABC operon (PubMed=19201793). Thus, ykgEFG operon may contribute to lactate catabolism in E.coli, but under conditions other than those tested, or alternatively, the ykgEFG operon may be responsible for the catabolism of a metabolite other than (but perhaps related to) lactate in E.coli. That's why the profile was not extended to Pseudomonadota and this family rule is currently restricted to Bacillota (in fact seed alignment only contains Bacillales), waiting for characterization in E.coli. |