HAMAP rule MF_02116

General rule information [?]

Accession	MF_02116
Dates	22-FEB-2011 (Created) 19-NOV-2022 (Last updated, Version 10)

Name	FAPy_deform

Scope

Archaea; Methanobacteria

Archaea; Methanococci

Template

Q57580 (ARFB_METJA)

Triggered by

HAMAP; MF_02116 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ARFB

Protein name

RecName:		Full=2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase;
		Short=FAPy deformylase;
		EC 3.5.1.102;
AltName:		Full=Formamide hydrolase;

Gene name

arfB

Comments [?]

Function	Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
Catalytic activity	RHEA:27282: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+) EC 3.5.1.102
Cofactor	Fe(2+) Note: Requires one Fe(2+) ion for activity.
	Fe(2+) Zn(2+) Note: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
Pathway	Cofactor biosynthesis; coenzyme F420 biosynthesis.
	Cofactor biosynthesis; riboflavin biosynthesis.
Subunit	Homodimer.
Similarity	Belongs to the creatininase superfamily. FAPy deformylase family.

Keywords [?]

Hydrolase
Metal-binding
Iron
Zinc

Gene Ontology [?]

GO:0008198; Molecular function: ferrous iron binding.
GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0009231; Biological process: riboflavin biosynthetic process.
GO:0052645; Biological process: F420-0 metabolic process.

Cross-references [?]

Pfam	PF02633; Creatininase; 1;

Features [?]

From: ARFB_METJA (Q57580)

Key From To Description Tag Condition FTGroup

BINDING 28 28 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 E

BINDING 30 30 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 H

BINDING 39 39 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 D

BINDING 39 39 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 D

BINDING 107 107 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 H

Additional information [?]

Size range	221-260 amino acids
Related rules	None
Fusion	None

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