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HAMAP rule MF_02116

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General rule information [?]

Accession MF_02116
Dates 22-FEB-2011 (Created)
19-NOV-2022 (Last updated, Version 10)
Name FAPy_deform
Scope(s) Archaea
Template(s) Q57580 (ARFB_METJA); [ Recover all ]
Triggered by HAMAP; MF_02116 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ARFB
Protein name RecName: Full=2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase;
                 Short=FAPy deformylase;
AltName: Full=Formamide hydrolase;
Gene name Name=arfB;

Comments [?]

FUNCTIONCatalyzes the hydrolysis of the formamide of 2-amino-5- formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
CATALYTIC ACTIVITY Reaction=2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin- 4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+); Xref=Rhea:RHEA:27282, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:57258, ChEBI:CHEBI:59545; EC=;
COFACTOR Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Requires one Fe(2+) ion for activity.;
COFACTOR Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Requires an additional second metal ion that could be Fe(2+) or Zn(2+).;
PATHWAYCofactor biosynthesis; coenzyme F420 biosynthesis.
PATHWAYCofactor biosynthesis; riboflavin biosynthesis.
SIMILARITYBelongs to the creatininase superfamily. FAPy deformylase family.

Keywords [?]

Gene Ontology [?]

GO:0008198; Molecular function:ferrous iron binding
GO:0016811; Molecular function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0009231; Biological process:riboflavin biosynthetic process
GO:0052645; Biological process:F420-0 metabolic process

Cross-references [?]

Pfam PF02633; Creatininase; 1;

Features [?]

From: ARFB_METJA (Q57580)
Key From To Description Tag Condition FTGroup
BINDING 28 28 /ligand="Fe cation"
BINDING 30 30 /ligand="Fe cation"
BINDING 39 39 /ligand="Fe cation"
BINDING 39 39 /ligand="Fe cation"
BINDING 107 107 /ligand="Fe cation"

Additional information [?]

Size range 221-260 amino acids
Related rules None
Fusion Nter: None Cter: None

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