HAMAP rule MF_02116
General rule information
[?]
Accession | MF_02116 |
Dates | 22-FEB-2011 (Created) 19-NOV-2022 (Last updated, Version 10) |
Name | FAPy_deform |
Scope | Archaea; Methanobacteria
Archaea; Methanococci |
Template | Q57580 (ARFB_METJA) |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
Function | Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy). |
Catalytic activity | RHEA:27282: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)
EC 3.5.1.102 |
Cofactor | Fe(2+) Note: Requires one Fe(2+) ion for activity. |
Fe(2+) Zn(2+) Note: Requires an additional second metal ion that could be Fe(2+) or Zn(2+). |
|
Pathway | Cofactor biosynthesis; coenzyme F420 biosynthesis. |
Cofactor biosynthesis; riboflavin biosynthesis. | |
Subunit | Homodimer. |
Similarity | Belongs to the creatininase superfamily. FAPy deformylase family. |
Keywords
[?]
Gene Ontology
[?]
GO:0008198; Molecular function: ferrous iron binding.
GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0009231; Biological process: riboflavin biosynthetic process.
GO:0052645; Biological process: F420-0 metabolic process.
GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0009231; Biological process: riboflavin biosynthetic process.
GO:0052645; Biological process: F420-0 metabolic process.
Cross-references
[?]
Pfam | PF02633; Creatininase; 1; |
Features
[?]
From: ARFB_METJA (Q57580) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 28 | 28 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 | E | ||||||||
BINDING | 30 | 30 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 | H | ||||||||
BINDING | 39 | 39 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 | D | ||||||||
BINDING | 39 | 39 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 | D | ||||||||
BINDING | 107 | 107 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 | H |
Additional information
[?]
Size range | 221-260 amino acids |
Related rules | None |
Fusion | None |