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HAMAP rule MF_02116

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General rule information [?]

Accession MF_02116
Dates 22-FEB-2011 (Created)
19-NOV-2022 (Last updated, Version 10)
Name FAPy_deform
Archaea; Methanobacteria
Archaea; Methanococci
Template Q57580 (ARFB_METJA)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase;
Short=FAPy deformylase;
AltName: Full=Formamide hydrolase;
Gene name

Comments [?]

Function Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
Catalytic activity RHEA:27282: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)
Cofactor Fe(2+)
Note: Requires one Fe(2+) ion for activity.
Note: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
Pathway Cofactor biosynthesis; coenzyme F420 biosynthesis.
Cofactor biosynthesis; riboflavin biosynthesis.
Subunit Homodimer.
Similarity Belongs to the creatininase superfamily. FAPy deformylase family.

Keywords [?]

Gene Ontology [?]

GO:0008198; Molecular function: ferrous iron binding.
GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0009231; Biological process: riboflavin biosynthetic process.
GO:0052645; Biological process: F420-0 metabolic process.

Cross-references [?]

Pfam PF02633; Creatininase; 1;

Features [?]

From: ARFB_METJA (Q57580)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     28     28       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1     E  
BINDING     30     30       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     H  
BINDING     39     39       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1     D  
BINDING     39     39       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     D  
BINDING     107     107       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1     H  

Additional information [?]

Size range 221-260 amino acids
Related rules None
Fusion None