HAMAP rule MF_02120
General rule information
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Accession | MF_02120 |
Dates | 10-JUN-2011 (Created) 1-JUN-2023 (Last updated, Version 12) |
Name | LysA |
Scope | Bacteria
Archaea |
Templates | P9WIU7 (DCDA_MYCTU); P00861 (DCDA_ECOLI); E0IWI3 (DCDA_ECOLW); Q58497 (DCDA_METJA); B4XMC6 (DCDA_HELPX); Q5HG20 (DCDA_STAAC); O67262 (DCDA_AQUAE); Q9X1K5 (DCDA_THEMA); Q9KVL7 (DCDA_VIBCH): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. |
Catalytic activity | RHEA:15101: H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine
EC 4.1.1.20 |
Cofactor | pyridoxal 5'-phosphate |
Pathway | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1. |
Subunit | Homodimer. |
Similarity | Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily. |
Keywords
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Gene Ontology
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GO:0008836; Molecular function: diaminopimelate decarboxylase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.
Cross-references
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PROSITE | PS00878; ODR_DC_2_1; 1; |
PS00879; ODR_DC_2_2; 1; | |
Pfam | PF02784; Orn_Arg_deC_N; 1; |
PF00278; Orn_DAP_Arg_deC; 1; | |
PRINTS | PR01181; DAPDCRBXLASE; 1; |
PR01179; ODADCRBXLASE; 1; | |
NCBIfam | TIGR01048; LysA; 1; |
Features
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From: DCDA_MYCTU (P9WIU7) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 300 | 303 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | E-x-G-R | ||||||||
BINDING | 258 | 258 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | G | ||||||||
BINDING | 303 | 303 | /ligand="substrate | R | ||||||||
BINDING | 344 | 344 | /ligand="substrate | R | ||||||||
BINDING | 348 | 348 | /ligand="substrate | Y | ||||||||
BINDING | 376 | 376 | /ligand="substrate | E | ||||||||
BINDING | 405 | 405 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | Y | ||||||||
BINDING | 405 | 405 | /ligand="substrate | Y | ||||||||
MOD_RES | 72 | 72 | N6-(pyridoxal phosphate)lysine | K |
Additional information
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Size range | 379-474 amino acids |
Related rules | None |
Fusion | None |
Comments | RHEA:15102; |