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Annotation rule MF_02120
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General rule information [?]

Accession MF_02120
Dates 10-JUN-2011 (Created)
21-JAN-2020 (Last updated, Version 8)
Name LysA
Scope
Bacteria
Archaea
Templates P9WIU7 (DCDA_MYCTU); P00861 (DCDA_ECOLI); E0IWI3 (DCDA_ECOLW); Q58497 (DCDA_METJA); B4XMC6 (DCDA_HELPX); Q5HG20 (DCDA_STAAC); O67262 (DCDA_AQUAE); Q9X1K5 (DCDA_THEMA); Q9KVL7 (DCDA_VIBCH): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DCDA
Protein name
RecName: Full=Diaminopimelate decarboxylase;
Short=DAP decarboxylase;
Short=DAPDC;
EC 4.1.1.20;
Gene name
lysA

Comments [?]

Function Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Catalytic activity RHEA:15101: H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine
EC 4.1.1.20
Cofactor pyridoxal 5'-phosphate
Pathway Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.
Subunit Homodimer.
Similarity Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008836; Molecular function: diaminopimelate decarboxylase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.

Cross-references [?]

PROSITE PS00878; ODR_DC_2_1; 1;
PS00879; ODR_DC_2_2; 1;
Pfam PF02784; Orn_Arg_deC_N; 1;
PF00278; Orn_DAP_Arg_deC; 1;
PRINTS PR01181; DAPDCRBXLASE; 1;
PR01179; ODADCRBXLASE; 1;
TIGRFAMs TIGR01048; LysA; 1;

Features [?]

From: DCDA_MYCTU (P9WIU7)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     300     303       Pyridoxal phosphate binding     E-x-G-R  
BINDING     258     258       Pyridoxal phosphate; via amide nitrogen     G  
BINDING     303     303       Substrate     R  
BINDING     344     344       Substrate     R  
BINDING     348     348       Substrate     Y  
BINDING     376     376       Substrate     E  
BINDING     405     405       Pyridoxal phosphate     Y  
BINDING     405     405       Substrate     Y  
MOD_RES     72     72       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 379-474 amino acids
Related rules None
Fusion None
Comments RHEA:15102;