HAMAP rule MF_02120

General rule information [?]

Accession	MF_02120
Dates	10-JUN-2011 (Created) 1-JUN-2023 (Last updated, Version 12)

Name

LysA

Scope

Bacteria

Archaea

Templates

P9WIU7 (DCDA_MYCTU); P00861 (DCDA_ECOLI); E0IWI3 (DCDA_ECOLW); Q58497 (DCDA_METJA); B4XMC6 (DCDA_HELPX); Q5HG20 (DCDA_STAAC); O67262 (DCDA_AQUAE); Q9X1K5 (DCDA_THEMA); Q9KVL7 (DCDA_VIBCH): [Recover all]

Triggered by

HAMAP; MF_02120 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

DCDA

Protein name

RecName:		Full=Diaminopimelate decarboxylase;
		Short=DAP decarboxylase;
		Short=DAPDC;
		EC 4.1.1.20;

Gene name

lysA

Comments [?]

Function	Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Catalytic activity	RHEA:15101: H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine EC 4.1.1.20
Cofactor	pyridoxal 5'-phosphate
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.
Subunit	Homodimer.
Similarity	Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Keywords [?]

Amino-acid biosynthesis
Decarboxylase
Lyase
Lysine biosynthesis
Pyridoxal phosphate

Gene Ontology [?]

GO:0008836; Molecular function: diaminopimelate decarboxylase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.

Cross-references [?]

PROSITE	PS00878; ODR_DC_2_1; 1;
	PS00879; ODR_DC_2_2; 1;
Pfam	PF02784; Orn_Arg_deC_N; 1;
	PF00278; Orn_DAP_Arg_deC; 1;
PRINTS	PR01181; DAPDCRBXLASE; 1;
	PR01179; ODADCRBXLASE; 1;
NCBIfam	TIGR01048; LysA; 1;

Features [?]

From: DCDA_MYCTU (P9WIU7)

Key From To Description Tag Condition FTGroup

BINDING 300 303 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 E-x-G-R

BINDING 258 258 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 G

BINDING 303 303 /ligand="substrate R

BINDING 344 344 /ligand="substrate R

BINDING 348 348 /ligand="substrate Y

BINDING 376 376 /ligand="substrate E

BINDING 405 405 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 Y

BINDING 405 405 /ligand="substrate Y

MOD_RES 72 72 N6-(pyridoxal phosphate)lysine K

Additional information [?]

Size range	379-474 amino acids
Related rules	None
Fusion	None
Comments	RHEA:15102;

View rule in raw text format (no links)